TREM2, frontotemporal dementia-like disease, Nasu-Hakola disease, and Alzheimer dementia: A chicken and egg problem?

JAMA Neurology

Volumn 70, Issue 6, 2013, Pages 805-806

  Bianchin, Marino Muxfeldt ^a   Abujamra, Ana Lucia ^a   Izquierdo, Ivan ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1;

ALLELE; ALZHEIMER DISEASE; CLINICAL FEATURE; DISEASE COURSE; FRONTOTEMPORAL DEMENTIA; HUMAN; INFLAMMATION; LETTER; MICROGLIA; NEUROLOGIC DISEASE; NEUROPATHOLOGY; PRIORITY JOURNAL;

EID: 84878774646     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2013.453     Document Type: Letter

References (5)

1. Guerreiro RJ, Lohmann E, Brás JM, et al. Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement. JAMA Neurol. 2013;70(1):78-84.
2. Bianchin MM, Capella HM, Chaves DL, et al. Nasu-Hakola disease (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy- PLOSL): a dementia associated with bone cystic lesions: from clinical to genetic and molecular aspects. Cell Mol Neurobiol. 2004;24(1):1-24. (Pubitemid 38233726)
3. Guerreiro R, Wojtas A, Bras J, et al; Alzheimer Genetic Analysis Group. TREM2 variants in Alzheimer's disease. N Engl J Med. 2013;368(2):117-127.
4. Bianchin MM, Martin KC, de Souza AC, de Oliveira MA, Rieder CR. Nasu-Hakola disease and primary microglial dysfunction. Nat Rev Neurol. 2010;6(9):2p.
5. Querfurth HW, LaFerla FM. Alzheimer's disease. N Engl J Med. 2010;362(4):329-344.