Cytotoxicity of quantum dots and graphene oxide to erythroid cells and macrophages

Nanoscale Research Letters

Volumn 8, Issue 1, 2013, Pages 1-9

  Qu, Guangbo ^a   Wang, Xiaoyan ^a   Wang, Zhe ^a   Liu, Sijin ^a   Jiang, Guibing ^a  

^a RESEARCH CENTER FOR ECO ENVIRONMENTAL SCIENCES   (China)

Author keywords

Apoptosis; Erythroid cells; Graphene oxidative; Macrophages; Quantum dots; ROS

Indexed keywords

BLOOD; CELL DEATH; CELL PROLIFERATION; GRAPHENE; MACROPHAGES; MAMMALS; NANOCRYSTALS; NANOSTRUCTURED MATERIALS;

BIOLOGICAL EFFECTS; BIOLOGICAL INFLUENCES; BLOOD CIRCULATION; ERYTHROID CELLS; FETAL LIVER; INTRACELLULAR ACCUMULATION; REACTIVE OXYGEN SPECIES; SURFACE COATINGS;

SEMICONDUCTOR QUANTUM DOTS;

MUS;

EID: 84878755879     PISSN: 19317573     EISSN: 1556276X     Source Type: Journal    
DOI: 10.1186/1556-276X-8-198     Document Type: Article

References (36)

1. Pelley JL, Daar AS, Saner MA: State of academic knowledge on toxicity and biological fate of quantum dots. Toxicol Sci 2009, 112(2):276-296.
2. Yong KT, Law WC, Hu R, Ye L, Liu L, Swihart MT, Prasad PN: Nanotoxicity assessment of quantum dots: from cellular to primate studies. Chem Soc Rev 2012, 42(3):1236-1250.
3. Chang YL, Yang ST, Liu JH, Dong E, Wang YW, Cao AN, Liu YF, Wang HF: In vitro toxicity evaluation of graphene oxide on A549 cells. Toxicol Lett 2011, 200(3):201-210.
4. Zhang YB, Ali SF, Dervishi E, Xu Y, Li ZR, Casciano D, Biris AS: Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 Cells. ACS Nano 2010, 4(6):3181-3186.
5. Hardman R: A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environ Health Perspect 2006, 114(2):165-172.
6. Tang M, Xing T, Zeng J, Wang H, Li C, Yin S, Yan D, Deng H, Liu J, Wang M, Chen J, Ruan DY: Unmodified CdSe quantum dots induce elevation of cytoplasmic calcium levels and impairment of functional properties of sodium channels in rat primary cultured hippocampal neurons. Environ Health Perspect 2008, 116(7):915-922.
7. Varin A, Gordon S: Alternative activation of macrophages: immune function and cellular biology. Immunobiology 2009, 214(7):630-641.
8. Ganz T, Nemeth E: Regulation of iron acquisition and iron distribution in mammals. Biochimica Et Biophysica Acta-Molecular Cell Research 2006, 1763(7):690-699.
9. Nairz M, Weiss G: Molecular and clinical aspects of iron homeostasis: from anemia to hemochromatosis. Wien Klin Wochenschr 2006, 118(15-16):442-462.
10. Hentze MW, Muckenthaler MU, Andrews NC: Balancing acts: molecular control of mammalian iron metabolism. Cell 2004, 117(3):285-297.
11. Wang TT, Bai J, Jiang X, Nienhaus GU: Cellular uptake of nanoparticles by membrane penetration: a study combining confocal microscopy with FTIR spectroelectrochemistry. ACS Nano 2012, 6(2):1251-1259.
12. Qu GB, Zhang CW, Yuan L, He JY, Wang Z, Wang LX, Liu SJ, Jiang GB: Quantum dots impair macrophagic morphology and the ability of phagocytosis by inhibiting the Rho-associated kinase signaling. Nanoscale 2012, 4(7):2239-2244.
13. Liao KH, Lin YS, Macosko CW, Haynes CL: Cytotoxicity of graphene oxide and graphene in human erythrocytes and skin fibroblasts. ACS Appl. Mater. Inter. 2011, 3(7):2607-2615.
14. Sasidharan A, Panchakarla LS, Chandran P, Menon D, Nair S, Rao CNR, Koyakutty M: Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene. Nanoscale 2011, 3(6):2461-2464.
15. Li Y, Liu Y, Fu YJ, Wei TT, Le Guyader L, Gao G, Liu RS, Chang YZ, Chen CY: The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways. Biomaterials 2012, 33(2):402-411.
16. Chen GY, Yang HJ, Lu CH, Chao YC, Hwang SM, Chen CL, Lo KW, Sung LY, Luo WY, Tuan HY, Hu YC: Simultaneous induction of autophagy and tolllike receptor signaling pathways by graphene oxide. Biomaterials 2012, 33(27):6559-6569.
17. Liu W, Zhang SP, Wang LX, Qu C, Zhang CW, Hong L, Yuan L, Huang ZH, Wang Z, Liu SJ, Jiang GB: CdSe quantum dot (QD)-induced morphological and functional impairments to liver in mice. PLoS One 2011, 6(9):e24406.
18. Qu GB, Wang XY, Liu Q, Liu R, Yin NY, Ma J, Chen LQ, He JY, Liu SJ, Jiang GB: The ex vivo and in vivo biological performances of graphene oxide and the impact of surfactant on graphene oxide's biocompatibility. J Environ Sci 2013, 25(5):1-9.
19. Zhang J, Socolovsky M, Gross AW, Lodish HF: Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood 2003, 102(12):3938-3946.
20. Lok CN, Ho CM, Chen R, He QY, Yu WY, Sun H, Tam PK, Chiu JF, Che CM: Silver nanoparticles: partial oxidation and antibacterial activities. J Biol Inorg Chem 2007, 12(4):527-534.
21. Liu S, Goldstein RH, Scepansky EM, Rosenblatt M: Inhibition of Rho-associated kinase signaling prevents breast cancer metastasis to human bone. Cancer Res 2009, 69(22):8742-8751.
22. Liu Y, Pop R, Sadegh C, Brugnara C, Haase VH, Socolovsky M: Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood 2006, 108(1):123-133.
23. Vanoers MHJ, Reutelingsperger CPM, Kuyten GAM, Vondemborne AEGK, Koopman G: Annexin-V for flow cytometric detection of phosphatidylserine expression on B-cells undergoing apoptosis. Blood 1994, 84(10):A291-A291.
24. Cho SJ, Maysinger D, Jain M, Roder B, Hackbarth S, Winnik FM: Long-term exposure to CdTe quantum dots causes functional impairments in live cells. Langmuir 2007, 23(4):1974-1980.
25. Clift MJ, Rothen-Rutishauser B, Brown DM, Duffin R, Donaldson K, Proudfoot L, Guy K, Stone V: The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line. Toxicol Appl Pharmacol 2008, 232(3):418-427.
26. Zhang LW, Monteiro-Riviere NA: Mechanisms of quantum dot nanoparticle cellular uptake. Toxicol Sci 2009, 110(1):138-155.
27. Liu SJ, Bhattacharya S, Han A, Suragani RNVS, Zhao W, Fry RC, Chen JJ: Haem-regulated eIF2alpha kinase is necessary for adaptive gene expression in erythroid precursors under the stress of iron deficiency. Br J Haematol 2008, 143(1):129-137.
28. Zhang J, Lee EY, Liu Y, Berman SD, Lodish HF, Lees JA: pRB and E2F4 play distinct cell-intrinsic roles in fetal erythropoiesis. Cell Cycle 2010, 9(2):371-376.
29. Kawane K, Fukuyama H, Kondoh G, Takeda J, Ohsawa Y, Uchiyama Y, Nagata S: Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science 2001, 292(5521):1546-1549.
30. Suragani RNVS, Zachariah RS, Velazquez JG, Liu SJ, Sun CW, Townes TM, Chen JJ: Heme-regulated eIF2 alpha kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis. Blood 2012, 119(22): 5276-5284.
31. Singh SK, Singh MK, Nayak MK, Kumari S, Shrivastava S, Gracio JJA, Dash D: Thrombus inducing property of atomically thin graphene oxide sheets. ACS Nano 2011, 5(6):4987-4996.
32. Guihard S, Clay D, Cocault L, Saulnier N, Opolon P, Souyri M, Pages G, Pouyssegur J, Porteu F, Gaudry M: The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis. Blood 2010, 115(18):3686-3694.
33. Cheng FY, Su CH, Yang YS, Yeh CS, Tsai CY, Wu CL, Wu MT, Shieh DB: Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical applications. Biomaterials 2005, 26(7):729-738.
34. Kainthan RK, Gnanamani M, Ganguli M, Ghosh T, Brooks DE, Maiti S, Kizhakkedathu JN: Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA. Biomaterials 2006, 27(31):5377-5390.
35. Dobrovoiskaia MA, Clogston JD, Neun BW, Hall JB, Patri AK, McNeil SE: Method for analysis of nanoparticle hemolytic properties in vitro. Nano Lett 2008, 8(8):2180-2187.
36. Dobrovolskaia MA, McNeil SE: Immunological properties of engineered nanomaterials. Nat Nanotechnol 2007, 2(8):469-478.