Diphtheria, pertussis (whooping cough), and tetanus vaccine induced recurrent seizures and acute encephalopathy in a pediatric patient: Possibly due to pertussis fraction

Journal of Pharmacology and Pharmacotherapeutics

Volumn 3, Issue 1, 2012, Pages 71-73

  Patel, K Patel ^a   Patel, Tejas K ^a   Tripathi, C B ^a  

^a GOVERNMENT MEDICAL COLLEGE   (India)

Author keywords

Acute encephalopathy; recurrent seizures; whole cell DPT vaccine

Indexed keywords

CLOBAZAM; DIPHTHERIA PERTUSSIS TETANUS VACCINE; ETIRACETAM; MIDAZOLAM; PHENOBARBITAL; PHENYTOIN;

ACUTE BRAIN DISEASE; ARTICLE; BRAIN RADIOGRAPHY; CASE REPORT; CHILD HEALTH CARE; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE ASSOCIATION; DISEASE CONTROL; DRUG EFFECT; DRUG SAFETY; HUMAN; INFANT; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PERTUSSIS; RECURRENT DISEASE; SEIZURE; TONIC CLONIC SEIZURE; VACCINATION;

EID: 84878743355     PISSN: 0976500X     EISSN: None     Source Type: Journal    
DOI: 10.4103/0976-500X.92514     Document Type: Article

References (13)

1. Gogtay NJ, Kshirsagar NA. Probable DPT induced Generalized Tonic Clonic seizure. Available from: http://kem.edu/dept/clinical-pharmacology/adverse- event-month-case/case-october2003.htm. [Last cited on 2011 June 17].
2. Kulkarni GS, Patekar MN, Gogtay NJ, Deshmukh CT, Kshirsagar NA. Probable Diphtheria Pertussis Tetanus (DPT) vaccine induced encephalopathy and death. Available from: http://kem.edu/dept/clinical-pharmacology/adverse-event-month- case/case-june2005.htm. [Last cited on 2011 June 17].
3. Naranjo CA, Busto U, Seller EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reaction. Clin Pharmacol Ther 1981; 30: 239-55.
4. Sejvar JJ, Kohl KS, Bilynsky R, Blumberg D, Cvetkovich T, Galama J, et al. Encephalitis, myelitis, and acute disseminated encephalomyelitis (ADEM): Case definitions and guidelines for collection, analysis, and presentation of immunization safety data. Vaccine 2007; 25: 5771-92.
5. Schumock GT, Thornton JP. Focusing on the preventability of adverse drug reactions. Hosp Pharm 1992; 27: 538.
6. Hartwig SC, Siegel J, Schneider PJ. Preventability and severity assessment in reporting adverse drug reactions. Am J Hosp Pharm 1992; 49: 2229-32.
7. Freitas FR, Sato HK, Aranda CM, Arantes BA, Pacheco MA, Waldman EA. Adverse events following diphtheria, pertussis and tetanus vaccinations and factors associated with severity. Rev Saude Publica 2007; 41: 1032-41.
8. Vaccine safety and adverse events following immunization. Available from: http://www.who.int/immunization-monitoring/routine/immunization-adverse/en/ index.html. [Last cited on 2011 June 20].
9. Donnelly S, Loscher CE, Lynch MA, Mills KH. Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: Evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination. Infect Immun 2001; 69: 4217-23.
10. Geier DA, Geier MR. An evaluation of serious neurological disorders following immunization: A comparison of whole-cell pertussis and acellular pertussis vaccines. Brain Dev 2004; 26: 296-300.
11. Diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed DAPTACELTM. Available from: http://www.whale.to/a/p/DAPTACEL.pdf. [Last cited on 2011 June 17].
12. Pertussis vaccines: WHO position paper. Wkly Epidemiol Rec 2010; 85: 385-400.
13. Immunisation schedule. Available from: http://www.iapindia.org/ immunisation/immunisation-schedule. [Last cited on 2011 June 17].