Treatment of glaucomatous patients by means of food supplement to reduce the ocular discomfort: A double blind randomized trial

European Review for Medical and Pharmacological Sciences

Volumn 17, Issue 8, 2013, Pages 1117-1122

  Nebbioso, M ^a   Rusciano, D ^b   Pucci, B ^c   Zicari, A M ^a   Grenga, R ^a   Pescocolido, N ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Sooft SpA   (Italy)

^c IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

Benzalkonium chloride; Dry eye; Forskolin; Glaucoma; Ocular performance index; Rutin

Indexed keywords

BENZALKONIUM CHLORIDE; EYE DROPS; FORSKOLIN; PLACEBO; RIBOFLAVIN; RUTOSIDE; THIAMINE;

ADULT; AGED; ARTICLE; CHRONIC DRUG ADMINISTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRY EYE; GLAUCOMA; HUMAN; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; TREATMENT DURATION;

ADULT; AGED; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DRY EYE SYNDROMES; FORSKOLIN; GLAUCOMA; HUMANS; MIDDLE AGED; RIBOFLAVIN; RUTIN; THIAMINE;

EID: 84878667341     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. NO AUTHORS LISTED. The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international dry eye workshop.Ocul Surf 2007; 5: 75-92.
2. GOTO E, YAGI Y, MATSUMOTOY, TSUBOTA K. Impaired functional visual acuity of dry eye patients. Am J Ophthalmol 2002; 133: 181-186.
3. BEGLEY CG, CHALMERS RL, ABETZ L, VENKATARAMAN K, MERTZANIS P, CAFFERY BA, SNYDER C, EDRINGTON T, NELSON D, SIMPSON T. The relationship between habitual patient-reported symptoms and clinical signs among patients with dry eye of varying severity. Invest Ophthalmol Vis Sci 2003; 44: 4753-4761.
4. TOMLINSON A, KHANAL S, RAMAESH K, DIAPER C, MCFADYEN A. Tear film osmolarity: determination of a referent for dry eye diagnosis. Invest Ophthalmol Vis Sci 2006; 47: 4309-4315.
5. STEVENSON W, CHAUHAN SK, DANA R. Dry eye disease: an immune-mediated ocular surface disorder. Arch Ophthalmol 2012; 130: 90-100.
6. NIKKINEN A, LETHOSALO JI, UUSITAL H. The lacrimal glands of the rat and guinea pig are innervated by nerve fibers containing immunoreactivities for substance P and vasoactive intestinal peptide. Histochemistry 1984; 81: 23-27.
7. NEBBIOSO M, EVANGELISTA M, LIBRANDO A, DI BLASIO D, PESCOSOLIDO N. Fixed topical combinations in glaucomatous patients and ocular discomfort. Expert Opin Pharmacother 2012; 13: 1829-1835.
8. BAUDOUIN C. The vicious circle in dry eye syndrome: a mechanistic approach. J Fr Ophtalmol 2007; 30: 239-246.
9. BAUDOUIN C, PISELLA PJ, FILLACIER K, GOLDSCHILD M, BECQUET F, DE SAINT JEAN M, BÉCHETOILLE A. Ocular surface inflammatory changes induced by topical antiglaucoma drugs: human and animal studies. Ophthalmology 1999; 106: 556-563.
10. PISELLA PJ, POULIQUEN P, BAUDOUIN C. Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication. Br J Ophthalmol 2002; 86: 418-423.
11. NEBBIOSO M, LIBRANDO A, PLATEROTI AM, PESCOSOLIDO N. Iatrogenic dry eye disease: an eledoisin/carnitine and osmolyte drops study. Biomed Pharmacother 2013. In press.
12. GILBARD JP. Human tear film electrolyte concentrations in health and dry eye disease. Int Ophthalmol Clin 1994; 34: 27-36.
13. GILBARD JP, ROSSI SR, HEYDA KG.Ophthalmic solutions, the ocular surface, and a unique therapeutic artificial tear formulation. Am J Ophthalmol 1989; 107: 348-355.
14. JAHN R, PADEL U, PORSCH PH, SOLING HD. Adrenocor ticotropic hormone and alfa-melanocyte-stimulating hormone induce secretion and protein phosphorylation in the rat lacrimal gland activation of a cAMP-dependent pathway. Eur J Biochem 1982; 126: 623.
15. JURIC DM, LONCAR D, CARMAN-KRZAN M. Noradrenergic stimulation of BDNF synthesis in astrocytes: mediation via alpha1-and beta1/beta2-adrenergic receptors. Neurochem Int 2008; 52: 297-306.
16. NAKAHASHI T, FUJIMURA H, ALTAR CA, LI J, KAMBAYASHI J, TANDON NN, SUN B. Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor. FEBS Lett 2000: 24; 470: 113-117.
17. MEYER-FRANKE A, WILKINSON GA, KRUTTGEN A, HU M, MUNRO E, HANSON MG JR, REICHARDT LF, BARRES BA. Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. Neuron 1998; 21: 681-693.
18. VETRUGNO M, UVA MG, RUSSO V, IESTER M, CIANCAGLINI M, BRUSINI P, CENTOFANTI M, ROSSETTI LM. Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy. J Ocul Pharmacol Ther 2012; 28: 536-541.
19. NEBBIOSO M, BELCARO G, LIBRANDO A, RUSCIANO D, STEIGERWALT RD JR, PESCOSOLIDO N. FORSKOLIN and rutin prevent intraocular pressure spikes after Nd:YAG laser iridotomy. Panminerva Med 2012; 54(1 Suppl 4): 77-82.
20. PARK YH, CHIOU GC. Structure-activity relationship (SAR) between some natural flavonoids and ocular blood flow in the rabbit. J Ocul Pharmacol Ther 2004; 20: 35-42.
21. NEBBIOSO M, GREGORIO FD, PRENCIPE L, PECORELLA I. Psychophysical and electrophysiological testing in ocular hypertension. Optom Vis Sci 2011; 88: E928-939.
22. DARTT DA. Signal trasduction and control of lacrimal gland protein secretion: a review. Curr Eye Res 8: 619-636.