Autologous Cell Therapy. Will It Replace Dermal Fillers?

Facial Plastic Surgery Clinics of North America

Volumn 21, Issue 2, 2013, Pages 299-304

  Weiss, Robert A ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Maryland Laser Skin and Vein Institute ^*  (United States)

Author keywords

Aging face; Autologous cell therapy; Autologous fibroblasts; Facial rejuvenation; Wrinkle correction

Indexed keywords

PLACEBO;

CELL THERAPY; COMPARATIVE STUDY; FIBROBLAST; FIBROBLAST CULTURE; FOOD AND DRUG ADMINISTRATION; HUMAN; INJECTION SITE BLEEDING; INJECTION SITE CONTUSION; INJECTION SITE DERMATITIS; INJECTION SITE EDEMA; INJECTION SITE ERYTHEMA; INJECTION SITE IRRITATION; INJECTION SITE NODULE; INJECTION SITE PAIN; INJECTION SITE PRURITUS; INJECTION SITE SWELLING; PAPULE; PUNCH BIOPSY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; WRINKLE;

BIOCOMPATIBLE MATERIALS; CELLS, CULTURED; COSMETIC TECHNIQUES; FACE; FIBROBLASTS; HUMANS; HYALURONIC ACID; INJECTIONS, SUBCUTANEOUS; PREOPERATIVE CARE; REJUVENATION; SKIN AGING; TRANSPLANTATION, AUTOLOGOUS;

EID: 84878660278     PISSN: 10647406     EISSN: 15581926     Source Type: Journal    
DOI: 10.1016/j.fsc.2013.02.008     Document Type: Review

References (11)

1. Weiss R.A., Weiss M.A., Beasley K.L., et al. Autologous cultured fibroblast injection for facial contour deformities: a prospective, placebo-controlled, phase III clinical trial. Dermatol Surg 2007, 33(3):263-268.
2. Smith S.R., Munavalli G., Weiss R., et al. A multicenter, double-blind, placebo-controlled trial of autologous fibroblast therapy for the treatment of nasolabial fold wrinkles. Dermatol Surg 2012, 38(7 Pt 2):1234-1243.
3. Narins R.S., Brandt F., Leyden J., et al. A randomized, double-blind, multicenter comparison of the efficacy and tolerability of Restylane versus Zyplast for the correction of nasolabial folds. Dermatol Surg 2003, 29(6):588-595.
4. Brandt F.S., Cazzaniga A., Baumann L., et al. Investigator global evaluations of efficacy of injectable poly-l-lactic acid versus human collagen in the correction of nasolabial fold wrinkles. Aesthet Surg J 2011, 31(5):521-528.
5. Carruthers A., Carey W., De Lorenzi C., et al. Randomized, double-blind comparison of the efficacy of two hyaluronic acid derivatives, Restylane Perlane and Hylaform, in the treatment of nasolabial folds. Dermatol Surg 2005, 31(11 Pt 2):1591-1598. [discussion: 1598].
6. Baumann L.S., Shamban A.T., Lupo M.P., et al. Comparison of smooth-gel hyaluronic acid dermal fillers with cross-linked bovine collagen: a multicenter, double-masked, randomized, within-subject study. Dermatol Surg 2007, 33(Suppl 2):S128-S135.
7. Lamme E.N., Van Leeuwen R.T., Brandsma K., et al. Higher numbers of autologous fibroblasts in an artificial dermal substitute improve tissue regeneration and modulate scar tissue formation. J Pathol 2000, 190(5):595-603.
8. Narins R.S., Brandt F.S., Lorenc Z.P., et al. Twelve-month persistency of a novel ribose-cross-linked collagen dermal filler. Dermatol Surg 2008, 34(Suppl 1):S31-S39.
9. Smith S.R., Jones D., Thomas J.A., et al. Duration of wrinkle correction following repeat treatment with Juvederm hyaluronic acid fillers. Arch Dermatol Res 2010, 302(10):757-762. PubMed Central PMCID: 2970825.
10. Cohen J.L. Understanding, avoiding, and managing dermal filler complications. Dermatol Surg 2008, 34(Suppl 1):S92-S99.
11. Barnas J.L., Simpson-Abelson M.R., Brooks S.P., et al. Reciprocal functional modulation of the activation of T lymphocytes and fibroblasts derived from human solid tumors. J Immunol 2010, 185(5):2681-2692.