Intramuscular administration of PEGylated IGF-I improves skeletal muscle regeneration after myotoxic injury

Growth Hormone and IGF Research

Volumn 23, Issue 4, 2013, Pages 128-133

  Martins, Karen J B ^a   Gehrig, Stefan M ^a   Naim, Timur ^a   Saenger, Stefanie ^b   Baum, Dale ^a   Metzger, Friedrich ^b   Lynch, Gordon S ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

IGF I; Muscle regeneration; Myotoxic injury; PEGylated IGF I

Indexed keywords

INTERLEUKIN 6; MACROGOL; MESSENGER RNA; MYOD PROTEIN; MYOGENIN; MYOSIN HEAVY CHAIN; PEGYLATED SOMATOMEDIN C; PROTEIN KINASE B; RECOMBINANT SOMATOMEDIN C; SODIUM CHLORIDE; TRANSCRIPTION FACTOR PAX7; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WOUND HEALING PROMOTING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MUSCLE LEVEL; ENZYME ACTIVATION; FUNCTIONAL STATUS; GENE EXPRESSION; HISTOPATHOLOGY; MALE; MOUSE; MUSCLE CELL; MUSCLE FUNCTION; MUSCLE REGENERATION; MUSCULOSKELETAL INJURY; MYOTOXIC INJURY; NONHUMAN; NUCLEOTIDE SEQUENCE; OSMOTIC PUMP; PRIORITY JOURNAL; SKELETAL MUSCLE REGENERATION; TISSUE REPAIR; WOUND HEALING;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INJECTIONS, INTRAMUSCULAR; INSULIN-LIKE GROWTH FACTOR I; MALE; MICE; MICE, INBRED C57BL; MUSCLE DEVELOPMENT; MUSCLE, SKELETAL; MUSCULAR DISEASES; POLYETHYLENE GLYCOLS; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; RECOVERY OF FUNCTION; REGENERATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84878655043     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2013.03.002     Document Type: Article

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