Higher cardiorespiratory fitness attenuates arterial stiffening associated with the Ala54Thr polymorphism in FABP2

Physiological Genomics

Volumn 45, Issue 6, 2013, Pages 237-242

  Fujie, Shumpei ^a   Iemitsu, Motoyuki ^a   Murakami, Haruka ^b   Sanada, Kiyoshi ^a   Kawano, Hiroshi ^c   Gando, Yuko ^c   Kawakami, Ryoko ^c   Miyachi, Motohiko ^b  

^a RITSUMEIKAN UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^c WASEDA UNIVERSITY   (Japan)

Author keywords

Arteriosclerosis; Diastolic blood pressure; Peak oxygen uptake; Systolic blood pressure

Indexed keywords

ALANINE; FATTY ACID BINDING PROTEIN 2; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; THREONINE; TRIACYLGLYCEROL;

ADULT; AGED; ARTERIAL STIFFNESS; ARTICLE; ATTENUATION; CARDIORESPIRATORY FITNESS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 4; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; EXON; FEMALE; FITNESS; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; JAPANESE; MALE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; ALANINE; ARTERIES; BASE SEQUENCE; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; CROSS-SECTIONAL STUDIES; DNA PRIMERS; FATTY ACID-BINDING PROTEINS; FEMALE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; REAL-TIME POLYMERASE CHAIN REACTION; RESPIRATORY PHYSIOLOGICAL PHENOMENA; THREONINE;

EID: 84878625736     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00089.2012     Document Type: Article

References (38)

1. Alpers DH, Bass NM, Engle MJ, DeSchryver-Kecskemeti K. Intestinal fatty acid binding protein may favor differential apical fatty acid binding in the intestine. Biochim Biophys Acta 1483: 352-362, 2000.
2. Arnett DK, Evans GW, Riley WA. Arterial stiffness: a new cardiovascular risk factor? Am J Epidemiol 140: 669-682, 1994.
3. Auinger A, Helwig U, Rubin D, Herrmann J, Jahreis G, Pfeuffer M, de Vrese M, Foelsch UR, Schreiber S, Doering F, Schrezenmeir J. Human intestinal fatty acid binding protein 2 expression is associated with fat intake and polymorphisms. J Nutr 140: 1411-1417, 2010.
4. Baier LJ, Sacchettini JC, Knowler WC, Eads J, Paolisso G, Tataranni PA, Mochizuki H, Bennett PH, Bogardus C, Prochazka M. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J Clin Invest 95: 1281-1287, 1995.
5. Besnard P, Niot I, Poirier H, Clement L, Bernard A. New insights into the fatty acid-binding protein (FABP) family in the small intestine. Mol Cell Biochem 239: 139-147, 2002.
6. Blacher J, Asmar R, Djane S, London GM, Safar ME. Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension 33: 1111-1117, 1999.
7. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14: 377-381, 1982.
8. Buscemi S, Canino B, Batsis JA, Buscemi C, Calandrino V, Mattina A, Arnone M, Caimi G, Cerasola G, Verga S. Relationships between maximal oxygen uptake and endothelial function in healthy male adults: a preliminary study. Acta Diabetol 2010, published online.
9. Cooper KH, Pollock ML, Martin RP, White SR, Linnerud AC, Jackson A. Physical fitness levels vs selected coronary risk factors. A cross-sectional study. JAMA 236: 166-169, 1976.
10. Erkkilä AT, Lindi V, Lehto S, Pyörälä K, Laakso M, Uusitupa MI. Variation in the fatty acid binding protein 2 gene is not associated with markers of metabolic syndrome in patients with coronary heart disease. Nutr Metab Cardiovasc Dis 12: 53-59, 2002.
11. Ferreira I, Twisk JW, Stehouwer CD, van Mechelen W, Kemper HC. Longitudinal changes in VO2max: associations with carotid IMT and arterial stiffness. Med Sci Sports Exerc 35: 1670-1678, 2003.
12. Formanack ML, Baier LJ. Variation in the FABP2 promoter affects gene expression: implications for prior association studies. Diabetologia 47: 349-351, 2004.
13. Galluzzi JR, Cupples LA, Otvos JD, Wilson PW, Schaefer EJ, Ordovas JM. Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in the Framingham Offspring Study. Atherosclerosis 159: 417-424, 2001.
14. Gastaldi M, Dizière S, Defoort C, Portugal H, Lairon D, Darmon M, Planells R. Sex-specific association of fatty acid binding protein 2 and microsomal triacylglycerol transfer protein variants with response to dietary lipid changes in the 3-mo Medi-RIVAGE primary intervention study. Am J Clin Nutr 86: 1633-1641, 2007.
15. Georgopoulos A, Aras O, Tsai MY. Codon-54 polymorphism of the fatty acid-binding protein 2 gene is associated with elevation of fasting and postprandial triglyceride in type 2 diabetes. J Clin Endocrinol Metab 85: 3155-3160, 2000.
16. Helwig U, Rubin D, Klapper M, Li Y, Nothnagel M, Fölsch UR, Döring F, Schreiber S, Schrezenmeir J. The association of fatty acidbinding protein 2 A54T polymorphism with postprandial lipemia depends on promoter variability. Metabolism 56: 723-731, 2007.
17. Iemitsu M, Maeda S, Otsuki T, Sugawara J, Tanabe T, Jesmin S, Kuno S, Ajisaka R, Miyauchi T, Matsuda M. Polymorphism in endothelin-related genes limits exercise-induced decreases in arterial stiffness in older subjects. Hypertension 47: 928-936, 2006.
18. Iemitsu M, Murakami H, Sanada K, Yamamoto K, Kawano H, Gando Y, Miyachi M. Lack of carotid stiffening associated with MTHFR 677TT genotype in cardiorespiratory fit adults. Physiol Genomics 42: 259-265, 2010.
19. Ishii T, Hirose H, Kawai T, Hayashi K, Maruyama H, Saito I, Saruta T. Effects of intestinal fatty acid-binding protein gene Ala54Thr polymorphism and 3-adrenergic receptor gene Trp64Arg polymorphism on insulin resistance and fasting plasma glucose in young to older Japanese men. Metabolism 50: 1301-1307, 2001.
20. Kawano H, Tanaka H, Miyachi M. Resistance training and arterial compliance: keeping the benefits while minimizing the stiffening. J Hypertens 24: 1753-1759, 2006.
21. Kim CH, Yun SK, Byun DW, Yoo MH, Lee KU, Suh KI. Codon 54 polymorphism of the fatty acid binding protein 2 gene is associated with increased fat oxidation and hyperinsulinemia, but not with intestinal fatty acid absorption in Korean men. Metabolism 50: 473-476, 2001.
22. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, Ducimetiere P, Benetos A. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37: 1236-1241, 2001.
23. Maeda S, Iemitsu M, Miyauchi T, Kuno S, Matsuda M, Tanaka H. Aortic stiffness and aerobic exercise: mechanistic insight from microarray analyses. Med Sci Sports Exerc 37: 1710-1716, 2005.
24. Maeda S, Miyauchi T, Kakiyama T, Sugawara J, Iemitsu M, Irukayama-Tomobe Y, Murakami H, Kumagai Y, Kuno S, Matsuda M. Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans. Life Sci 69: 1005-1016, 2001.
25. Miyachi M, Kawano H, Sugawara J, Takahashi K, Hayashi K, Yamazaki K, Tabata I, Tanaka H. Unfavorable effects of resistance training on central arterial compliance: a randomized intervention study. Circulation 110: 2858-2863, 2004.
26. Mohiaddin RH, Underwood SR, Bogren HG, Firmin DN, Klipstein RH, Rees RS, Longmore DB. Regional aortic compliance studied by magnetic resonance imaging: the effects of age, training, and coronary artery disease. Br Heart J 62: 90-96, 1989.
27. Rowe JW. Clinical consequences of age-related impairments in vascular compliance. Am J Cardiol 60: 68G-71G, 1987.
28. Sawada S, Tanaka H, Funakoshi M, Shindo M, Kono S, Ishiko T. Five year prospective study on blood pressure and maximal oxygen uptake. Clin Exp Pharmacol Physiol 20: 483-487, 1993.
29. Sipiläinen R, Uusitupa M, Heikkinen S, Rissanen A, Laakso M. Variants in the human intestinal fatty acid binding protein 2 gene in obese subjects. J Clin Endocrinol Metab 82: 2629-2632, 1997.
30. Tahvanainen E, Molin M, Vainio S, Tiret L, Nicaud V, Farinaro E, Masana L, Ehnholm C. Intestinal fatty acid binding protein polymorphism at codon 54 is not associated with postprandial responses to fat and glucose tolerance tests in healthy young Europeans. Results from EARS II participants. Atherosclerosis 152: 317-325, 2000.
31. Takakura Y, Yoshioka K, Umekawa T, Kogure A, Toda H, Yoshikawa T, Yoshida T. Thr54 allele of the FABP2 gene affects resting metabolic rate and visceral obesity. Diabetes Res Clin Pract 67: 36-42, 2005.
32. Tanaka H, DeSouza CA, Seals DR. Absence of age-related increase in central arterial stiffness in physically active women. Arterioscler Thromb Vasc Biol 18: 127-132, 1998.
33. Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA, Seals DR. Aging, habitual exercise, and dynamic arterial compliance. Circulation 102: 1270-1275, 2000.
34. Tanaka H, Monahan KD, Seals DR. Age-predicted maximal heart rate revisited. J Am Coll Cardiol 37: 153-156, 2001.
35. Vimaleswaran KS, Radha V, Mohan V. Thr54 allele carriers of the Ala54Thr variant of FABP2 gene have associations with metabolic syndrome and hypertriglyceridemia in urban South Indians. Metabolism 55: 1222-1226, 2006.
36. Wanby P, Nilsson I, Brudin L, Nyhammar I, Gustafsson I, Carlsson M. Increased plasma levels of asymmetric dimethylarginine in patients with carotid stenosis: no evidence for the role of the common FABP2 A54T gene polymorphism. Acta Neurol Scand 115: 90-96, 2007.
37. Wanby P, Palmquist P, Brudin L, Carlsson M. Genetic variation of the intestinal fatty acid-binding protein 2 gene in carotid atherosclerosis. Vasc Med 10: 103-108, 2005.
38. Zhao T, Nzekebaloudou M, lv J. Ala54Thr polymorphism of fatty acid-binding protein 2 gene and fasting blood lipids: a meta-analysis. Atherosclerosis 210: 461-467, 2010.