Synthesizing evidence: Shifting the focus from individual studies to the body of evidence

JAMA

Volumn 309, Issue 21, 2013, Pages 2217-2218

  Murad, M Hassan ^a   Montori, Victor M ^a  

^a Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; EVIDENCE BASED MEDICINE; HUMAN; INTERVENTION STUDY; MEDICAL DECISION MAKING; MEDICAL EDUCATION; MEDICAL RESEARCH; POLICY; PRIORITY JOURNAL; SHORT SURVEY; STUDY DESIGN;

EID: 84878619556     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2013.5616     Document Type: Short Survey

References (7)

1. Bastian H, Glasziou P, Chalmers I. Seventy-five trials and eleven systematic reviews a day: how will we ever keep up? PLoS Med. 2010;7(9):e1000326.
2. Clarke M, Alderson P, Chalmers I. Discussion sections in reports of controlled trials published in general medical journals. JAMA. 2002;287(21):2799-2801. (Pubitemid 34591967)
3. Ioannidis JP, Trikalinos TA. Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trials. J Clin Epidemiol. 2005;58(6):543-549.
4. Borm GF, Lemmers O, Fransen J, Donders R. The evidence provided by a single trial is less reliable than its statistical analysis suggests. J Clin Epidemiol. 2009;62(7):711-715.
5. Guyatt GH, Mills EJ, Elbourne D. In the era of systematic reviews, does the size of an individual trial still matter? PLoS Med. 2008;5(1):e4.
6. Halpern SD, Karlawish JH, Berlin JA. The continuing unethical conduct of underpowered clinical trials. JAMA. 2002;288(3):358-362. (Pubitemid 34761615)
7. Inthout J, Ioannidis JP, Borm GF. Obtaining evidence by a single well-powered trial or several modestly powered trials [published online October 14, 2012]. Stat Methods Med Res. 2012. doi:10.1177/0962280212461098.