Vγ2Vσ2 T cells are skewed toward a terminal differentiation phenotype in untreated HIV infection

Journal of Infectious Diseases

Volumn 208, Issue 1, 2013, Pages 180-182

  Hartjen, Philip ^a,b   Meyer Olson, Dirk ^c   Lehmann, Clara ^d   Stellbrink, Hans Jürgen ^e   Van Lunzen, Jan ^a,b   Wiesch, Julian Schulze Zur ^a,b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

^e Infektionsmedizinisches Centrum Hamburg   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD3 ANTIGEN; CD56 ANTIGEN;

CD4+ T LYMPHOCYTE; DISEASE COURSE; EFFECTOR CELL; GAMMA DELTA T LYMPHOCYTE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; LYMPHOCYTE DIFFERENTIATION; MEMORY T LYMPHOCYTE; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VIRUS LOAD; VIRUS PATHOGENESIS;

FEMALE; HIV; HIV INFECTIONS; HUMANS; MALE; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; VIRUS REPLICATION;

EID: 84878617798     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit141     Document Type: Letter

References (8)

1. Boudová S, Li H, Sajadi MM, Redfield RR, Pauza CD. Impact of persistent HIV replication on CD4 negative Vgamma2Vdelta2 T cells. J Infect Dis 2012; 205:1448-55.
2. Deeks SG, Walker BD. Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity 2007; 27:406-16.
3. Li H, Peng H, Ma P, et al. Association between Vgamma2Vdelta2 T cells and disease progression after infection with closely related strains of HIV in China. Clin Infect Dis 2008; 46:1466-72.
4. Gougeon ML, Garcia S, Heeney J, et al. Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res Hum Retroviruses 1993; 9:553-63.
5. Papagno L, Spina CA, Marchant A, et al. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol 2004; 2:E20.
6. Harris LD, Klatt NR, Vinton C, et al. Mechanisms underlying gammadelta T-cell subset perturbations in SIV-infected Asian rhesus macaques. Blood 2010; 116:4148-57.
7. Cairo C, Armstrong CL, Cummings JS, et al. Impact of age, gender, and race on circulating gammadelta T cells. Hum Immunol 2010; 71:968-75.
8. Caccamo N, Dieli F, Wesch D, Jomaa H, Eberl M. Sex-specific phenotypical and functionaldifferences in peripheral human Vgamma9/Vdelta2 T cells. J Leukoc Biol 2006; 79:663-6.