IgG subclass staining in renal biopsies with membranous glomerulonephritis indicates subclass switch during disease progression

Modern Pathology

Volumn 26, Issue 6, 2013, Pages 799-805

  Huang, Cheng Cheng ^a   Lehman, Amy ^a   Albawardi, Alia ^a   Satoskar, Anjali ^a   Brodsky, Sergey ^a   Nadasdy, Gyongyi ^a   Hebert, Lee ^a   Rovin, Brad ^a   Nadasdy, Tibor ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Igg subclass; membranous glomerulonephritis

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4;

ARTICLE; DISEASE COURSE; ELECTRON MICROSCOPY; HUMAN; IMMUNOFLUORESCENCE; KIDNEY BIOPSY; MAJOR CLINICAL STUDY; MEMBRANOUS GLOMERULONEPHRITIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

BIOLOGICAL MARKERS; BIOPSY; COMPLEMENT C1Q; DISEASE PROGRESSION; FLUORESCENT ANTIBODY TECHNIQUE; GLOMERULONEPHRITIS, MEMBRANOUS; HUMANS; IMMUNOGLOBULIN G; KIDNEY GLOMERULUS; MICROSCOPY, ELECTRON; RECEPTORS, PHOSPHOLIPASE A2;

EID: 84878580688     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2012.237     Document Type: Article

References (26)

1. Schwartz M. Membranous glomerulonephritis, In: Jennette JC, Olson JL, Schwartz MM, Silva FG(eds) Heptinstall's Pathology of the Kidney, 6th edn. Lippincott Williams & Wilkins: Philadelphia; 2007, pp 205-251.
2. Beck LH Jr, Bonegio RG, Lambeau G, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 2009;361:11-21.
3. Hofstra JM, Beck LH Jr, Beck DM, et al. Antiphospholipase A2 receptor antibodies correlate with clinical status in idiopathic membranous nephropathy. Clin J Am Soc Nephrol 2011;6:1286-1291.
4. Qin W, Beck LH Jr, Zeng C, et al. Anti-phospholipase A2 receptor antibody in membranous nephropathy. J Am Soc Nephrol 2011;22:1137-1143.
5. Prunotto M, Carnevali ML, Candiano G, et al. Autoimmunity in membranous nephropathy targets aldose reductase and SOD2. J Am Soc Nephrol 2010;21: 507-519.
6. Bruschi M, Ml Carnevali, Murtas C, et al. Direct characterization of target podocyte antigens and autoantibodies in human membranous glomerulonephritis: Alpha-enolase and borderline antigens. J Proteomics 2011;74:2008-2017.
7. Debiec H, Lefeu F, Kemper MJ, et al. Early-childhood membranous nephropathy due to cationic bovine serum albumin. N Engl J Med 0211;364:2101-10.
8. Murtas C, Bruschi M, Candiano G, et al. Coexistence of different circulating anti-podocyte antibodies in membranous nephropathy. Clin J Am Soc Nephrol 2012;7: 1394-1400.
9. Doi T, Mayumi M, Kanatsu K, et al. Distribution of IgG subclasses in membranous nephropathy. Clin Exp Immunol 1984;58:57-62.
10. Noel LH, Aucouturier P, Monteiro RC, et al. Glomerular and serum immunoglobulin G subclasses in membranous nephropathy and anti-glomerular basement membrane nephritis. Clin Immunol Immunopathol 1988;46:186-194.
11. Haas M. IgG subclass deposits in glomeruli of lupus and nonlupus membranous nephropathies. Am J Kidney Dis 1994;23:358-364.
12. Kuroki A, Shibata T, Honda H, et al. Glomerular and serum IgG subclasses in diffuse proliferative lupus nephritis, membranous lupus nephritis, and idiopathic membranous nephropathy. Intern Med 2002; 41:936-942.
13. Kearney N, Podolak J, Matsumura L, et al. Patterns of IgG subclass deposits in membranous glomerulonephritis in renal allografts. Transplant Proc 2011;43: 3743-3746.
14. Ohtani H,Wakui H, Komatsuda A, et al. Distribution of glomerular IgG subclass deposits in malignancyassociated membranous nephropathy. Nephrol Dial Transplant 2004;19:574-579.
15. Omokawa A, Komatsuda A, Nara M, et al. Distribution of glomerular IgG subclass deposits in patients with membranous nephropathy and anti-U1 ribonucleoprotein antibody. Nephrol Dial Transplant 2012;27:1937-1941.
16. Qu Z, Liu G, Wu LH, et al. Absence of glomerular IgG4 deposition in patients with membranous nephropathy may indicate malignancy. Nephrol Dial Transplant 2012;27:1931-1937.
17. Ehrenreich T, Chung J. Pathology of membranous nephropathy. Pathol Annu 1968;3:145-186.
18. Satoskar AA, Brodsky SV, Nadasdy G, et al. Discrepancies in glomerular and tubulointerstitial/vascular immune complex IgG subclasses in lupus nephritis. Lupus 2011;20:1396-1403.
19. Schroeder H, Cavacini L. Structure and function of immunoglobulins. J Allergy Clin Immunol 2010; 125:S41-S52.
20. Tongren JE, Drakeley CJ, McDonald SL, et al. Target antigen, age, and duration of antigen exposure independently regulate immunoglobulin G subclass switching in malaria. Infect Immun 2006;74:257-264.
21. Sousa AO, Henry S, Maroja FM, et al. IgG subclass distribution of antibody responses to protein and polysaccharide mycobacterial antigens in leprosy and tuberculosis patients. Clin Exp Immunol 1998;111: 48-55.
22. Baida H, Biselli PJC, Juvenale M, et al. Differential antibody isotype expression to the major Paracoccidioides brasiliensis antigen in juvenile and adult form paracoccidioidomycosis. Microbes Infect 1999;1:273-278.
23. Segawa Y, Hisano S, Matsushita M, et al. IgG subclasses and complement pathway in segmental and global membranous nephropathy. Pediatr Nephrol 2010;25:1091-1099.
24. Schulze M, Donadio JV Jr., Pruchno CJ, et al. Elevated urinary excretion of the C5b-9 complex in membranous nephropathy. Kidney Int 1991;40:533-538.
25. Couser WG, Schulze M, Pruchno CJ. Role of C5b-9 in experimental membranous nephropathy. Nephrol Dial Transplant 1992;7(Suppl 1):25-31.
26. Kon SP, Coupes B, Short CD, et al. Urinary C5b-9 excretion and clinical course in idiopathic human membranous nephropathy. Kidney Int 1995;48: 1953-1958.