Assessment of glycosaminoglycan content in intervertebral discs using chemical exchange saturation transfer at 3.0 Tesla: Preliminary results in patients with low-back pain

European Radiology

Volumn 23, Issue 3, 2013, Pages 861-868

  Haneder, Stefan ^a,b   Apprich, Sebastian R ^a   Schmitt, Benjamin ^a   Michaely, Henrik J ^b   Schoenberg, Stefan O ^b   Friedrich, Klaus M ^a   Trattnig, Siegfried ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

3.0 T; Gag CEST; Intervertebral disc; Lower back pain; Pfirrmann score

Indexed keywords

GLYCOSAMINOGLYCAN;

ADULT; AGED; ANNULUS FIBROSUS; ARTICLE; CLINICAL ARTICLE; FEASIBILITY STUDY; FEMALE; GLYCOSAMINOGLYCAN DEPENDENT CHEMICAL EXCHANGE SATURATION TRANSFER; HUMAN; IN VIVO STUDY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; LOW BACK PAIN; MALE; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; NUCLEUS PULPOSUS; PFIRRMANN GRADE; PRIORITY JOURNAL; RELAXATION TIME; SCORING SYSTEM; SPINE;

EID: 84878568219     PISSN: 09387994     EISSN: 14321084     Source Type: Journal    
DOI: 10.1007/s00330-012-2660-6     Document Type: Article

References (24)

1. Airaksinen O, Brox JI, Cedraschi C et al (2006) Chapter 4. European guidelines for the management of chronic nonspecific low back pain. Eur Spine J 15(Suppl 2):S192-S300
2. Andersson GB (1999) Epidemiological features of chronic low-back pain. Lancet 354:581-585
3. Balague F, Mannion AF, Pellise F, Cedraschi C (2012) Non-specific low back pain. Lancet 379:482-491
4. Becker A, Held H, Redaelli M et al (2012) Implementation of a guideline for low back pain management in primary care: a cost-effectiveness analysis. Spine (Phila Pa 1976) 37:701-710
5. Chou R, Fu R, Carrino JA, Deyo RA (2009) Imaging strategies for low-back pain: systematic review and meta-analysis. Lancet 373:463-472
6. Deyo RA, Mirza SK, Martin BI (2006) Back pain prevalence and visit rates: estimates from U.S. national surveys, 2002. Spine (Phila Pa 1976) 31:2724-2727
7. Eyre DR, Muir H (1977) Quantitative analysis of types I and II collagens in human intervertebral discs at various ages. Biochim Biophys Acta 492:29-42
8. Graves JM, Fulton-Kehoe D, Jarvik JG, Franklin GM (2012) Early imaging for acute low back pain: one-year health and disability outcomes among Washington State workers. Spine (Phila Pa 1976)
9. Hart LG, Deyo RA, Cherkin DC (1995) Physician office visits for low back pain. Frequency, clinical evaluation, and treatment patterns from a U.S. national survey. Spine (Phila Pa 1976) 20:11-19
10. Insko EK, Clayton DB, Elliott MA (2002) In vivo sodium MR imaging of the intervertebral disk at 4 T. Acad Radiol 9:800-804
11. Jarvik JG, Deyo RA (2000) Imaging of lumbar intervertebral disk degeneration and aging, excluding disk herniations. Radiol Clin North Am 38:1255-1266
12. Jarvik JG, Hollingworth W, Martin B et al (2003) Rapid magnetic resonance imaging vs radiographs for patients with low back pain: a randomized controlled trial. JAMA 289:2810-2818
13. Kim M, Chan Q, Anthony MP, Cheung KM, Samartzis D, Khong PL (2011) Assessment of glycosaminoglycan distribution in human lumbar intervertebral discs using chemical exchange saturation transfer at 3 T: feasibility and initial experience. NMR Biomed 24:1137-1144
14. Lyons G, Eisenstein SM, Sweet MB (1981) Biochemical changes in intervertebral disc degeneration. Biochim Biophys Acta 673:443-453
15. Mehra M, Hill K, Nicholl D, Schadrack J (2012) The burden of chronic low back pain with and without a neuropathic component: a healthcare resource use and cost analysis. J Med Econ 15:245-252
16. Meisel HJ, Siodla V, Ganey T, Minkus Y, Hutton WC, Alasevic OJ (2007) Clinical experience in cell-based therapeutics: disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc. Biomol Eng 24:5-21
17. Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N (2001) Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976) 26:1873-1878
18. Saar G, Zhang B, Ling W, Regatte RR, Navon G, Jerschow A (2012) Assessment of glycosaminoglycan concentration changes in the intervertebral disc via chemical exchange saturation transfer. NMR Biomed 25:255-261
19. Sheehan NJ (2010) Magnetic resonance imaging for low back pain: indications and limitations. Ann Rheum Dis 69:7-11
20. Stelzeneder D, Welsch GH, Kovacs BK et al (2012) Quantitative T2 evaluation at 3.0 T compared to morphological grading of the lumbar intervertebral disc: a standardized evaluation approach in patients with low back pain. Eur J Radiol 81:324-330
21. Trattnig S, Stelzeneder D, Goed S et al (2010) Lumbar intervertebral disc abnormalities: comparison of quantitative T2 mapping with conventional MR at 3.0 T. Eur Radiol 20:2715-2722
22. Urban JP, McMullin JF (1985) Swelling pressure of the inervertebral disc: influence of proteoglycan and collagen contents. Biorheology 22:145-157
23. Urban JP, Winlove CP (2007) Pathophysiology of the intervertebral disc and the challenges for MRI. J Magn Reson Imaging 25:419-432
24. van Zijl PC, Yadav NN (2011) Chemical exchange saturation transfer (CEST): what is in a name and what isn't? Magn Reson Med 65:927-948