New evidence about an old drug - Risk with codeine after adenotonsillectomy

New England Journal of Medicine

Volumn 368, Issue 23, 2013, Pages 2155-2157

  Racoosin, Judith A ^a   Roberson, David W ^b,c,d   Pacanowski, Michael A ^a   Nielsen, David R ^b  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b American Academy of Otolaryngology   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; CODEINE 6 GLUCURONIDE; CYTOCHROME P450 2D6; HYDROCODONE; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE; NORCODEINE; OXYCODONE;

ADENOIDECTOMY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG SAFETY; DRUG STRUCTURE; ETHNIC DIFFERENCE; GENETIC VARIABILITY; HUMAN; PAIN; PERSONALIZED MEDICINE; PHARMACOGENOMICS; PRIORITY JOURNAL; RESPIRATION DEPRESSION; SHORT SURVEY; SLEEP DISORDERED BREATHING; TONSILLECTOMY;

EID: 84878531001     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMp1302454     Document Type: Article

References (5)

1. Crews KR, Gaedigk A, Dunnenberger HM, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clin Pharmacol Ther 2012;91:321-6.
2. Kelly LE, Rieder M, van den Anker J, et al. More codeine fatalities after tonsillectomy in North American children. Pediatrics 2012;129(5):e1343-e1347.
3. Goldman JL, Baugh RF, Davies L, et al. Mortality and major morbidity after tonsillectomy: etiologic factors and strategies for prevention. Laryngoscope (in press).
4. Brown KA, Laferrière A, Lakheeram I, Moss IR. Recurrent hypoxemia in children is associated with increased analgesic sensitivity to opiates. Anesthesiology 2006;105:665-9.
5. Baugh RF, Archer SM, Mitchell RB, et al. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg 2011;144:Suppl:S1-S30.