Epidemiology, clinical-treatment patterns and outcome in 256 hepatocellular carcinoma cases

World Journal of Gastroenterology

Volumn 19, Issue 21, 2013, Pages 3207-3216

  Fenoglio, Luigi ^a   Serraino, Cristina ^a   Castagna, Elisabetta ^a   Cardellicchio, Adele ^a   Pomero, Fulvio ^a   Grosso, Maurizio ^a   Senore, Carlo ^b  

^a S CROCE E CARLE HOSPITAL   (Italy)

^b CITTÀ DELLA SALUTE E DELLA SCIENZA HOSPITAL   (Italy)

Author keywords

Clinical characteristics; Epidemiology; Hepatocellular carcinoma; Surveillance; Survival

Indexed keywords

ALPHA FETOPROTEIN; BILIRUBIN; SORAFENIB; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR;

ADULT; AGED; ARTICLE; CANCER MORTALITY; CANCER SURVIVAL; CHRONIC LIVER DISEASE; DISEASE SEVERITY; FEMALE; FOLLOW UP; HEPATITIS B; HEPATITIS C; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; OUTCOME ASSESSMENT; PALLIATIVE THERAPY; RISK FACTOR;

EID: 84878528334     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i21.3207     Document Type: Article

References (40)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001; 94: 153-156[PMID: 11668491 DOI: 10.1002/ijc.1440]
2. Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med 2006; 144: 705-714[PMID: 16702586]
3. Chung H, Ueda T, Kudo M. Changing trends in hepatitis C infection over the past 50 years in Japan. Intervirology 2010; 53: 39-43[PMID: 20068339 DOI: 10.1159/000252782]
4. Seeff LB. Introduction: The burden of hepatocellular carcinoma. Gastroenterology 2004; 127: S1-S4[PMID: 15508071 DOI: 10.1053/j.gastro.2004.09.010]
5. Yasui K, Hashimoto E, Komorizono Y, Koike K, Arii S, Imai Y, Shima T, Kanbara Y, Saibara T, Mori T, Kawata S, Uto H, Takami S, Sumida Y, Takamura T, Kawanaka M, Okanoue T. Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. Clin Gastroenterol Hepatol 2011; 9: 428-433.quiz e50[PMID: 21320639 DOI: 10.1016/j.cgh.2011.01.023]
6. Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, Christensen E, Pagliaro L, Colombo M, Rodés J. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 2001; 35: 421-430[PMID: 11592607 DOI: 10.1016/ S0168-8278(01)00130-1]
7. Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology 2011; 53: 1020-1022[PMID: 21374666 DOI: 10.1002/hep.24199]
8. Sherman M. Surveillance for hepatocellular carcinoma and early diagnosis. Clin Liver Dis 2007; 11: 817-837, viii[PMID: 17981230 DOI: 10.1016/j.cld.2007.08.011]
9. El-Serag HB. Hepatocellular carcinoma. N Engl J Med 2011; 365: 1118-1127[PMID: 21992124 DOI: 10.1056/NEJMra1001683]
10. El-Serag HB, Marrero JA, Rudolph L, Reddy KR. Diagnosis and treatment of hepatocellular carcinoma. Gastroenterology 2008; 134: 1752-1763[PMID: 18471552 DOI: 10.1053/ j.gastro.2008.02.090]
11. Llovet JM, Brú C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 1999; 19: 329-338[PMID: 10518312 DOI: 10.1055/s-2007-1007122]
12. Forner A, Reig ME, de Lope CR, Bruix J. Current strategy for staging and treatment: the BCLC update and future prospects. Semin Liver Dis 2010; 30: 61-74[PMID: 20175034 DOI: 10.1055/s-0030-1247133]
13. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003; 362: 1907-1917[PMID: 14667750 DOI: 10.1016/ S0140-6736(03)14964-1]
14. Giannini EG, Bodini G, Corbo M, Savarino V, Risso D, Di Nolfo MA, Del Poggio P, Benvegnù L, Farinati F, Zoli M, Borzio F, Caturelli E, Chiaramonte M, Trevisani F. Impact of evidence-based medicine on the treatment of patients with unresectable hepatocellular carcinoma. Aliment Pharmacol Ther 2010; 31: 493-501[PMID: 19912152 DOI: 10.1111/ j.1365-2036.2009.04198.x]
15. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60: 646-649[PMID: 4541913 DOI: 10.1002/bjs.1800600817]
16. Trevisani F, Caraceni P, Bernardi M, D'Intino PE, Arienti V, Amorati P, Stefanini GF, Grazi G, Mazziotti A, Fornalè L. Gross pathologic types of hepatocellular carcinoma in Italian patients. Relationship with demographic, environmental, and clinical factors. Cancer 1993; 72: 1557-1563[PMID: 8394197]
17. AIRT Working Group. Italian cancer figures--report 2006: 1. Incidence, mortality and estimates. Epidemiol Prev 2006; 30: 8-10, 12-28, 30-101 passim[PMID: 16826725]
18. Bosetti C, Bianchi C, Negri E, Colombo M, La Vecchia C. Estimates of the incidence and prevalence of hepatocellular carcinoma in Italy in 2002 and projections for the years 2007 and 2012. Tumori 2009; 95: 23-27[PMID: 19366051]
19. Sangiovanni A, Del Ninno E, Fasani P, De Fazio C, Ronchi G, Romeo R, Morabito A, De Franchis R, Colombo M. Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology 2004; 126: 1005-1014[PMID: 15057740 DOI: 10.1053/ j.gastro.2003.12.049]
20. Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 2004; 127: S35-S50[PMID: 15508101 DOI: 10.1053/ j.gastro.2004.09.014]
21. Trevisani F, Magini G, Santi V, Morselli-Labate AM, Cantarini MC, Di Nolfo MA, Del Poggio P, Benvegnù L, Rapaccini G, Farinati F, Zoli M, Borzio F, Giannini EG, Caturelli E, Bernardi M. Impact of etiology of cirrhosis on the survival of patients diagnosed with hepatocellular carcinoma during surveillance. Am J Gastroenterol 2007; 102: 1022-1031[PMID: 17313497 DOI: 10.1111/j.1572-0241.2007.01100.x]
22. Nordenstedt H, White DL, El-Serag HB. The changing pattern of epidemiology in hepatocellular carcinoma. Dig Liver Dis 2010; 42 Suppl 3: S206-S214[PMID: 20547305 DOI: 10.1016/S1590-8658(10)60507-5]
23. El-Serag HB, Tran T, Everhart JE. Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology 2004; 126: 460-468[PMID: 14762783]
24. Zhang BH, Yang BH, Tang ZY. Randomized controlled trial of screening for hepatocellular carcinoma. J Cancer Res Clin Oncol 2004; 130: 417-422[PMID: 15042359 DOI: 10.1007/ s00432-004-0552-0]
25. Bolondi L, Sofia S, Siringo S, Gaiani S, Casali A, Zironi G, Piscaglia F, Gramantieri L, Zanetti M, Sherman M. Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis. Gut 2001; 48: 251-259[PMID: 11156649 DOI: 10.1136/gut.48.2.251]
26. Kuo YH, Lu SN, Chen CL, Cheng YF, Lin CY, Hung CH, Chen CH, Changchien CS, Hsu HC, Hu TH, Lee CM, Wang JH. Hepatocellular carcinoma surveillance and appropriate treatment options improve survival for patients with liver cirrhosis. Eur J Cancer 2010; 46: 744-751[PMID: 20060710 DOI: 10.1016/j.ejca.2009.12.018]
27. Lencioni R. Surveillance and early diagnosis of hepatocellular carcinoma. Dig Liver Dis 2010; 42 Suppl 3: S223-S227[PMID: 20547307 DOI: 10.1016/S1590-8658(10)60509-9]
28. Santi V, Trevisani F, Gramenzi A, Grignaschi A, Mirici- Cappa F, Del Poggio P, Di Nolfo MA, Benvegnù L, Farinati F, Zoli M, Giannini EG, Borzio F, Caturelli E, Chiaramonte M, Bernardi M. Semiannual surveillance is superior to annual surveillance for the detection of early hepatocellular carcinoma and patient survival. J Hepatol 2010; 53: 291-297[PMID: 20483497 DOI: 10.1016/j.jhep.2010.03.010]
29. Tseng PL, Wang JH, Tung HD, Hung CH, Kee KM, Chen CH, Chang KC, Lee CM, Changchien CS, Chen PF, Tsai LS, Lu SN. Optimal treatment increased survival of hepatocellular carcinoma patients detected with community-based screening. J Gastroenterol Hepatol 2010; 25: 1426-1434[PMID: 20659234 DOI: 10.1111/j.1440-1746.2010.06285.x]
30. Farinati F, Sergio A, Baldan A, Giacomin A, Di Nolfo MA, Del Poggio P, Benvegnu L, Rapaccini G, Zoli M, Borzio F, Giannini EG, Caturelli E, Trevisani F. Early and very early hepatocellular carcinoma: when and how much do staging and choice of treatment really matter? A multicenter study. BMC Cancer 2009; 9: 33[PMID: 19171074 DOI: 10.1186/1471-2407-9-33]
31. Borzio M, Colloredo G, Pioltelli P, Quagliuolo M. Epidemiology and outcome of hepatocellular carcinoma in Lombardy. Dig Liver Dis 2007; 39: 1011-1017[PMID: 17936698 DOI: 10.1016/j.dLd.2007.06.018]
32. El-Serag HB, Siegel AB, Davila JA, Shaib YH, Cayton- Woody M, McBride R, McGlynn KA. Treatment and outcomes of treating of hepatocellular carcinoma among Medicare recipients in the United States: a population-based study. J Hepatol 2006; 44: 158-166[PMID: 16290309 DOI: 10.1016/j.jhep.2005.10.002]
33. Llovet JM, Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology 2003; 37: 429-442[PMID: 12540794 DOI: 10.1053/jhep.2003.50047]
34. Bruix J, Sala M, Llovet JM. Chemoembolization for hepatocellular carcinoma. Gastroenterology 2004; 127: S179-S188[PMID: 15508083 DOI: 10.1053/j.gastro.2004.09.032]
35. Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology 2005; 42: 1208-1236[PMID: 16250051 DOI: 10.1002/hep.20933]
36. Kemp W, Pianko S, Nguyen S, Bailey MJ, Roberts SK. Survival in hepatocellular carcinoma: impact of screening and etiology of liver disease. J Gastroenterol Hepatol 2005; 20: 873-881[PMID: 15946134 DOI: 10.1111/j.1440-1746.2005.03844.x]
37. Stravitz RT, Heuman DM, Chand N, Sterling RK, Shiffman ML, Luketic VA, Sanyal AJ, Habib A, Mihas AA, Giles HC, Maluf DG, Cotterell AH, Posner MP, Fisher RA. Surveillance for hepatocellular carcinoma in patients with cirrhosis improves outcome. Am J Med 2008; 121: 119-126[PMID: 18261500 DOI: 10.1016/j.amjmed.2007.09.020]
38. Toyoda H, Kumada T, Kiriyama S, Sone Y, Tanikawa M, Hisanaga Y, Yamaguchi A, Isogai M, Kaneoka Y, Washizu J. Impact of surveillance on survival of patients with initial hepatocellular carcinoma: a study from Japan. Clin Gastroenterol Hepatol 2006; 4: 1170-1176[PMID: 16890027 DOI: 10.1016/j.cgh.2006.06.007]
39. Chan AC, Poon RT, Ng KK, Lo CM, Fan ST, Wong J. Changing paradigm in the management of hepatocellular carcinoma improves the survival benefit of early detection by screening. Ann Surg 2008; 247: 666-673[PMID: 18362630 DOI: 10.1097/SLA.0b013e31816a747a]
40. Chen JG, Parkin DM, Chen QG, Lu JH, Shen QJ, Zhang BC, Zhu YR. Screening for liver cancer: results of a randomised controlled trial in Qidong, China. J Med Screen 2003; 10: 204-209[PMID: 14738659]