A Novel Benzothiazole Derivative YLT322 Induces Apoptosis via the Mitochondrial Apoptosis Pathway In Vitro with Anti-Tumor Activity in Solid Malignancies

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Xuejiao, Song ^a   Yong, Xia ^a   Ningyu, Wang ^a   Lidan, Zhang ^b   Xuanhong, Shi ^a   Youzhi, Xu ^a   Tinghong, Ye ^a   Yaojie, Shi ^a   Yongxia, Zhu ^a   Luoting, Yu ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO N [2 [2 (5 METHYLPYRIDIN 2 YLAMINO) 2 OXOETHYLTHIO] BENZO[D]THIAZOL 6 YL] ACETAMIDE; ACETYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; ACETYLLEUCYLGLUTAMYLHISTIDINYLASPARTYL FLUOROMETHYL KETONE; BENZOTHIAZOLE DERIVATIVE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 8 INHIBITOR; CASPASE 9; CASPASE 9 INHIBITOR; CYTOCHROME C; DOXORUBICIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P22; UNCLASSIFIED DRUG; YLT 322;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; ENZYME INHIBITION; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR XENOGRAFT;

AMINOPYRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZOTHIAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOCHROMES C; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS;

EID: 84878517451     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063900     Document Type: Article

References (37)

1. Baffy G, (2012) Editorial: Hepatocellular Carcinoma in Type 2 Diabetes: More Than Meets the Eye. Am J Gastroenterol 107: 53-55.
2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al. (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90.
3. Seitz SJ, Schleithoff ES, Koch A, Schuster A, Teufel A, et al. (2010) Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway. Int J Cancer 126: 2049-2066.
4. Llovet JM, Bruix J, (2008) Molecular targeted therapies in hepatocellular carcinoma. Hepatology 48: 1312-1327.
5. Mott JL, Gores GJ, (2007) Piercing the armor of hepatobiliary cancer: Bcl-2 homology domain 3 (BH3) mimetics and cell death. Hepatology 46: 906-911.
6. Belka C, Jendrossek V, Pruschy M, Vink S, Verheij M, et al. (2004) Apoptosis-modulating agents in combination with radio-therapy-current status and outlook. Int J Radiat Oncol Biol Phys 58: 542-554.
7. Fesik WS, (2005) Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 5: 876-885.
8. Elmore S, (2007) Apoptosis: A review of programmed cell death. Toxicol Pathol 35: 495-516.
9. Soengas MS, Lowe SW, (2003) Apoptosis and melanoma chemoresistance. Oncogene 22: 3138-3151.
10. Wang Z, Shi XH, Wang J, Zhou T, Xu YZ, et al. (2011) Synthesis, structure activity relationships and preliminary antitumor evaluation of benzothiazole-2-thiol derivatives as novel apoptosis inducers. Bioorg Med Chem Lett 21: 1097-1101.
11. Kaur H, Kumar S, Singh I, Sxena KK, Kuma A, (2010) Synthesis, characterization and biological activity of various substituted benzothiazole derivatives. Dig J Nanomater Bios 5: 67-76.
12. Song EY, Kaur N, Park MY, Jin Y, Lee K, et al. (2008) Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor. Eur J Med Chem 43: 1519-1524.
13. Shi XH, Wang Z, Xia Y, Ye TH, Deng M, et al. (2012) Synthesis and biological evaluation of novel benzothiazole-2-thiol derivatives as potential anticancer agents. Molecules 17: 3933-3944.
14. Ali S, Banerjee S, Ahmad A, El-Rayes BF, Philip PA, et al. (2008) Apoptosis-inducing effect of erlotinib is potentiated by 3,3-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther 7: 1708-19.
15. Xu YZ, Zheng RL, Zhou Y, Peng F, Lin HJ, et al. (2011) Small molecular anticancer agent SKLB703 induces apoptosis in human hepatocellular carcinoma cells via the mitochondrial apoptotic pathway in vitro and inhibits tumor growth in vivo. Cancer Lett 313: 44-53.
16. Cory S, Huang DC, Adams JM, (2003) The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22: 8590-8607.
17. Ratajczak J, Majka M, Kijowski J, Baj M, Pan ZK, et al. (2001) Biological significance of MAPK, AKT and JAK-STAT protein activation by various erythropoietic factors in normal human early erythroid cells. Br J Haematol 115: 195-204.
18. Kline MP, Rajkumar SV, Timm MM, Kimlinger TK, Haug JL, et al. (2008) R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells. Exp Hematol 36: 568-576.
19. Hanahan D, Weinberg RA, (2000) The hallmarks of cancer. Cell 100: 57-70.
20. Nicholson DW, (2000) From bench to clinic with apoptosis-based therapeutic agents. Nature 407: 810-816.
21. Arends MJ, Wyllie AH, (1991) Apoptosis: Mechanismsand roles in pathology. Int Rev Exp Pathol 32: 223-254.
22. Choi MJ, Jung KH, Kim D, Lee H, Zheng HM, et al. (2011) Anti-cancer effects of a novel compound HS-113 on cell growth, apoptosis, and angiogenesis in human hepatocellular carcinoma cells. Cancer Lett 306: 190-196.
23. Mesner PW Jr, Budihardjo I, Kaufmann SH, (1997) Chemotherapy-induced apoptosis. Adv Pharmacol 41: 461-499.
24. Li ZG, Zhao YL, Wu X, Ye HY, Peng A, et al. (2009) Barbigerone a natural isoflavone induces apoptosis in murine lung-cancer cells via the mitochondrial apoptotic pathway. Cell Physiol Biochem 24: 95-104.
25. Liu M, Pelling JC, Ju J, Chu E, Brash DE, (1998) Antioxidant action via p53-mediatedapoptosis. Cancer Res 58: 1723-1729.
26. Inoue M, Suzuki R, Koide T, Sakaguchi N, Ogihara Y, et al. (1994) induces apoptosis in HL-60RG cells. Biochem Biophys Res Commun 204: 898-904.
27. Breous E, Thimme R, (2011) Potential of immunotherapy for hepatocellular carcinoma. J Hepatol 54: 830-834.
28. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X, (1999) Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15: 269-290.
29. Mielgo A, Torres VA, Schmid MC, Graf R, Zeitlin SG, et al. (2009) The death effector domains of caspase-8 induce terminal differentiation. PLoS One 4: e7879.
30. Trisciuoglio D, Ragazzoni Y, Pelosi A, Desideri M, Carradori S, et al. (2012) CPTH6, a Thiazole Derivative, Induces Histone Hypoacetylation and Apoptosis in Human Leukemia Cells. Clin Cancer Res 18: 475-486.
31. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, et al. (2001) Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730.
32. Shimizu S, Narita M, Tsujimoto Y, (1999) Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399: 483-487.
33. Amundson SA, Myers T, Scudiero D, Kitada S, Reed JC, et al. (2000) An informatics approach indentifying markers of chemosensitivity in human cancer cells. Cancer Res 60: 6101-6110.
34. Minn AJ, Rudin CM, Boise LH, Thompson CB, (1995) Expression of bcl-xL can confer a multidrug resistance phenotype. Blood 86: 1903-1910.
35. Chun KH, Kosmeder JW, Sun SH, Pezzuto JM, Lotan R, et al. (2003) Effects of Deguelin on the Phosphatidylinositol 3-Kinase/Akt Pathway and Apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst 95: 291-302.
36. Kennedy SG, Kandel ES, Cross TK, Hay N, (1999) Akt/protein kinase B inhibits cell death by preventing the re-lease of cytochrome C from mitochondria. Mol Cell Biol 19: 5800-5810.
37. Orlowski RZ, Small GW, Shi YY, (2002) Evidence That Inhibition of p44/42 Mitogen-activated Protein Kinase Signaling Is a Factor in Proteasome Inhibitor-mediated Apoptosis. J Biol Chem 277: 27864-27871.