Update on hydrocodone metabolites in rats and dogs aided with a semi-automatic software for metabolite identification Mass-MetaSite

Xenobiotica

Volumn 43, Issue 4, 2013, Pages 390-398

  Li, Austin C ^a   Chovan, James P ^a   Yu, Erya ^a   Zamora, Ismael ^b  

^a TEVA PHARMACEUTICALS   (Israel)

^b Lead Molecular Design   (Spain)

Author keywords

opioid receptor agonist; Hydrocodone; Hydromorphone; Metabolism; Norhydrocodone

Indexed keywords

DRUG METABOLITE; GLUCURONIDE; HYDROCODOL; HYDROCODONE; HYDROCODONE BITARTRATE; HYDROCODONE N OXIDE 1; HYDROCODONE N OXIDE 2; HYDROMORPHOL; HYDROMORPHONE; KETONE; NORHYDROCODONE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; COMPUTER PROGRAM; DEMETHYLATION; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG SAFETY; DRUG STRUCTURE; MALE; NONHUMAN; OXIDATION; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY;

ANIMALS; AUTOMATION; DEUTERIUM EXCHANGE MEASUREMENT; DOGS; HYDROCODONE; MALE; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; SOFTWARE;

CANIS FAMILIARIS; RATTUS;

EID: 84878503643     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2012.715697     Document Type: Article

References (11)

1. Bonn B, Leandersson C, Fontaine F, Zamora I. (2010). Enhanced metabolite identification with MS(E) and a semi-Automated software for structural elucidation. Rapid Commun Mass Spectrom 24:3127-3138
2. Christrup LL. (1997). Morphine metabolites. Acta Anaesthesiol Scand 41:116-122 (Pubitemid 27072914)
3. Clarke NJ, Rindgen D, Korfmacher WA, Cox KA. (2001). Systematic LC/MS metabolite identification in drug discovery. Anal Chem 73:430A-439A. (Pubitemid 32862353)
4. Cone EJ, Darwin WD, Gorodetzky CW, Tan T. (1978). Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog. Drug Metab Dispos 6:488-493 (Pubitemid 8399700)
5. Lelas S, Wegert S, Otton SV, Sellers EM, France CP. (1999). Inhibitors of cytochrome P450 differentially modify discriminative-stimulus and antinociceptive effects of hydrocodone and hydromorphone in rhesus monkeys. Drug Alcohol Depend 54:239-249 (Pubitemid 29150313)
6. Li AC, Ding J, Jiang X, Denissen J. (2009). Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: Demonstration with buspirone metabolite identification. Rapid Commun Mass Spectrom 23:3003-3012
7. Li AC, Yu E, Ring SC, Chovan JP. (2012). Identification of imine or enamine drug metabolites using online hydrogen/deuterium exchange and exact mass measurements. Rapid Commun Mass Spectrom 26:906-914
8. Lötsch J, Geisslinger G. (2001). Morphine-6-glucuronide: An analgesic of the future? Clin Pharmacokinet 40:485-499 (Pubitemid 32738656)
9. Otton SV, Schadel M, Cheung SW, Kaplan HL, Busto UE, Sellers EM. (1993). CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone. Clin Pharmacol Ther 54:463-472 (Pubitemid 23349082)
10. Prakash C, Shaffer CL, Nedderman A. (2007). Analytical strategies for identifying drug metabolites. Mass Spectrom Rev 26:340-369 (Pubitemid 46750374)
11. Weston DJ, Weidolf L. (2012). Conference Report: High-resolution MS in drug discovery and development: Current applications and future perspectives. Bioanalysis 4:481-486