Reduced motoneuron excitability in a rat model of sepsis

Journal of Neurophysiology

Volumn 109, Issue 7, 2013, Pages 1775-1781

  Nardelli, Paul ^a   Khan, Jaffar ^b   Powers, Randall ^c   Cope, Tim C ^a   Rich, Mark M ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Action potential; Critical illness myopathy; Critical illness neuropathy; Motor neuron

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CASE REPORT; CENTRAL NERVOUS SYSTEM; ELECTROMYOGRAM; HUMAN; LIMB WEAKNESS; MOTONEURON; MOTOR NERVE CONDUCTION; NERVE CELL EXCITABILITY; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; SPINAL NERVE;

ACTION POTENTIALS; ANIMALS; CRITICAL ILLNESS; DISEASE MODELS, ANIMAL; HUMANS; MEMBRANE POTENTIALS; MOTOR NEURONS; MUSCLE WEAKNESS; RATS; SPINAL CORD; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 84878473154     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00936.2012     Document Type: Article

References (33)

1. Bolton CF. Neuromuscular manifestations of critical illness. Muscle Nerve 32: 140-163, 2005.
2. Boucher PA, Joos B, Morris CE. Coupled left-shift of Nav channels: modeling the Na(+)-loading and dysfunctional excitability of damaged axons. J Comput Neurosci 33: 301-319, 2012.
3. Brownstone RM, Krawitz S, Jordan LM. Reversal of the late phase of spike frequency adaptation in cat spinal motoneurons during fictive locomotion. J Neurophysiol 105: 1045-1050, 2010.
4. Bullinger KL, Nardelli P, Pinter MJ, Alvarez FJ, Cope TC. Permanent central synaptic disconnection of proprioceptors after nerve injury and regeneration. II. Loss of functional connectivity with motoneurons. J Neurophysiol 106: 2471-2485, 2011.
5. Button DC, Gardiner K, Marqueste T, Gardiner PF. Frequency-current relationships of rat hindlimb alpha-motoneurones. J Physiol 573: 663-677, 2006.
6. Cheung AM, Tansey CM, Tomlinson G, Diaz-Granados N, Matte A, Barr A, Mehta S, Mazer CD, Guest CB, Stewart TE, Al-Saidi F, Cooper AB, Cook D, Slutsky AS, Herridge MS. Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med 174: 538-544, 2006.
7. Dai Y, Jordan LM. Tetrodotoxin-, dihydropyridine-, and riluzole-resistant persistent inward current: novel sodium channels in rodent spinal neurons. J Neurophysiol 106: 1322-1340, 2011.
8. De Luca CJ, Contessa P. Hierarchical control of motor units in voluntary contractions. J Neurophysiol 107: 178-195, 2012.
9. Filatov GN, Rich MM. Hyperpolarized shifts in the voltage dependence of fast inactivation of Nav1.4 and Nav1.5 in a rat model of critical illness myopathy. J Physiol 559: 813-820, 2004.
10. Fletcher SN, Kennedy DD, Ghosh IR, Misra VP, Kiff K, Coakley JH, Hinds CJ. Persistent neuromuscular and neurophysiologic abnormalities in long-term survivors of prolonged critical illness. Crit Care Med 31: 1012-1016, 2003.
11. Flierl MA, Rittirsch D, Huber-Lang MS, Stahel PF. Pathophysiology of septic encephalopathy-an unsolved puzzle. Crit Care 14: 165, 2010.
12. Hamm TM, Turkin VV, Bandekar NK, O'Neill D, Jung R. Persistent currents and discharge patterns in rat hindlimb motoneurons. J Neurophysiol 104: 1566-1577, 2010.
13. Heckman CJ, Hyngstrom AS, Johnson MD. Active properties of motoneurone dendrites: diffuse descending neuromodulation, focused local inhibition. J Physiol 586: 1225-1231, 2008.
14. Heckman CJ, Lee RH, Brownstone RM. Hyperexcitable dendrites in motoneurons and their neuromodulatory control during motor behavior. Trends Neurosci 26: 688-695, 2003.
15. Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al-Saidi F, Cooper AB, Guest CB, Mazer CD, Mehta S, Stewart TE, Barr A, Cook D, Slutsky AS. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 348: 683-693, 2003.
16. Kernell D. The Motoneurone and its Muscle Fibres. Oxford, UK: Oxford Univ. Press, 2006.
17. Khan J, Harrison TB, Rich MM. Mechanisms of neuromuscular dysfunction in critical illness. Crit Care Clin 24: 165-177, 2008.
18. Khan J, Harrison TB, Rich MM, Moss M. Early development of critical illness myopathy and neuropathy in patients with severe sepsis. Neurology 67: 1421-1425, 2006.
19. Latronico N, Bolton CF. Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. Lancet Neurol 10: 931-941, 2011.
20. Miles GB, Dai Y, Brownstone RM. Mechanisms underlying the early phase of spike frequency adaptation in mouse spinal motoneurones. J Physiol 566: 519-532, 2005.
21. Novak KR, Nardelli P, Cope TC, Filatov G, Glass JD, Khan J, Rich MM. Inactivation of sodium channels underlies reversible neuropathy during critical illness in rats. J Clin Invest 119: 1150-1158, 2009.
22. Powers RK, Binder MD. Input-output functions of mammalian motoneurons. Rev Physiol Biochem Pharmacol 143: 137-263, 2001.
23. Pytel P, Alexander JJ. Pathogenesis of septic encephalopathy. Curr Opin Neurol 22: 283-287, 2009.
24. Rekling JC, Funk GD, Bayliss DA, Dong XW, Feldman JL. Synaptic control of motoneuronal excitability. Physiol Rev 80: 767-852, 2000.
25. Rich MM, Bird SJ, Raps EC, McCluskey LF, Teener JW. Direct muscle stimulation in acute quadriplegic myopathy. Muscle Nerve 20: 665-673, 1997.
26. Rich MM, Pinter MJ. Crucial role of sodium channel fast inactivation in muscle fibre inexcitability in a rat model of critical illness myopathy. J Physiol 547: 555-566, 2003.
27. Rich MM, Pinter MJ. Sodium channel inactivation in an animal model of acute quadriplegic myopathy. Ann Neurol 50: 26-33, 2001.
28. Rich MM, Pinter MJ, Kraner SD, Barchi RL. Loss of electrical excitability in an animal model of acute quadriplegic myopathy. Ann Neurol 43: 171-179, 1998.
29. Rich MM, Teener JW, Raps EC, Schotland DL, Bird SJ. Muscle is electrically inexcitable in acute quadriplegic myopathy. Neurology 46: 731-736, 1996.
30. Sciamanna G, Wilson CJ. The ionic mechanism of gamma resonance in rat striatal fast-spiking neurons. J Neurophysiol 106: 2936-2949, 2011.
31. Stevens RD, Marshall SA, Cornblath DR, Hoke A, Needham DM, de Jonghe B, Ali NA, Sharshar T. A framework for diagnosing and classifying intensive care unit-acquired weakness. Crit Care Med 37: S299-S308, 2009.
32. Yu N, Morris CE, Joós B, Longtin A. Spontaneous excitation patterns computed for axons with injury-like impairments of sodium channels and Na/K pumps. PLoS Comput Biol 8: e1002664, 2012.
33. Zochodne DW, Bolton CF, Wells GA, Gilbert JJ, Hahn AF, Brown JD, Sibbald WA. Critical illness polyneuropathy. A complication of sepsis and multiple organ failure. Brain 110: 819-841, 1987.