Reducing infectivity of HIV upon exposure to surfaces coated with N,N-dodecyl, methyl-polyethylenimine

Biotechnology and Bioengineering

Volumn 110, Issue 7, 2013, Pages 2058-2062

  Gerrard, Stephen E ^a,b,c   Larson, Alyssa M ^d   Klibanov, Alexander M ^d,e   Slater, Nigel K H ^a   Hanson, Carl V ^b   Abrams, Barbara F ^c   Morris, Mary K ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b VIRAL AND RICKETTSIAL DISEASE LABORATORY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Antiviral surface; Breastfeeding; HIV; Hydrophobic polycation; Mother to child transmission (of HIV); Polyethylenimine

Indexed keywords

BREASTFEEDING; HIV; MOTHER-TO-CHILD TRANSMISSION (OF HIV); POLYCATIONS; POLYETHYLENIMINES;

HYDROPHOBICITY; RNA;

DISEASES;

POLYETHYLENEIMINE; VIRUS PROTEIN; VIRUS RNA;

ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; RNA ANALYSIS; VERTICAL TRANSMISSION; VIRUS ATTACHMENT; VIRUS INFECTIVITY;

DISINFECTANTS; ENVIRONMENTAL MICROBIOLOGY; EQUIPMENT AND SUPPLIES; HIV; HUMANS; MICROBIAL VIABILITY; POLYETHYLENEIMINE; VIRAL LOAD;

EID: 84878398960     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24867     Document Type: Article

References (15)

1. Borkow G, Lara HH, Covington CY, Nyamathi A, Gabbay J. 2008. Deactivation of human immunodeficiency virus type 1 in medium by copper oxide-containing filters. Antimicrob Agents Chemother 52(2):518-525.
2. Borkow G, Covington CY, Gautam B, Anzala O, Oyugi J, Juma M, Abdullah MS. 2011. Prevention of Human immunodeficiency virus breastmilk transmission with copper oxide: Proof-of-concept study. Breastfeed Med 6(4):165-170.
3. Chasela CS, Hudgens MG, Jamieson DJ, Kayira D, Hosseinipour MC, Kourtis AP, Martinson F, Tegha G, Knight RJ, Ahmed YI, Kamwendo DD, Hoffman IF, Ellington SR, Kacheche Z, Soko A, Wiener JB, Fiscus SA, Kazembe P, Mofolo IA, Chigwenembe M, Sichali DS, van der Horst CM. 2010. Maternal or infant antiretroviral drugs to reduce HIV-1 transmission. N Engl J Med 362(24):2271-2281.
4. Gerrard SE, Baniecki ML, Sokal DC, Morris MK, Urdaneta-Hartmann S, Krebs FC, Wigdahl B, Abrams BF, Hanson CV, Slater NK, Edwards AD. 2012. A nipple shield delivery system for oral drug delivery to breastfeeding infants: Microbicide delivery to inactivate HIV. Int J Pharm 434(1-2):224-234.
5. Haldar J, An D, Alvarez de Cienfuegos L, Chen J, Klibanov AM. 2006. Polymeric coatings that inactivate both influenza virus and pathogenic bacteria. Proc Natl Acad Sci USA 103(47):17667-17671.
6. Haldar J, Weight AK, Klibanov AM. 2007. Preparation, application and testing of permanent antibacterial and antiviral coatings. Nat Protoc 2(10):2412-2417.
7. Hartmann SU, Berlin CM, Howett MK. 2006. Alternative modified infant-feeding practices to prevent postnatal transmission of human immunodeficiency virus type 1 through breast milk: Past, present, and future. J Human Lact 22(1):75-88.
8. Hsu BB, Ouyang J, Wong SY, Hammond PT, Klibanov AM. 2011a. On structural damage incurred by bacteria upon exposure to hydrophobic polycationic coatings. Biotechnol Lett 33(2):411-416.
9. Hsu BB, Yinn Wong S, Hammond PT, Chen J, Klibanov AM. 2011b. Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations. Proc Natl Acad Sci USA 108(1):61-66.
10. Kindra G, Coutsoudis A, Esposito F, Esterhuizen T. 2012. Breastfeeding in HIV exposed infants significantly improves child health: A prospective study. Matern Child Health J 16(3):632-640.
11. Klibanov AM. 2007. Permanently microbicidal materials coatings. J Mater Chem 17(24):2479-2482.
12. Larson AM, Hsu BB, Rautaray D, Haldar J, Chen J, Klibanov AM. 2011. Hydrophobic polycationic coatings disinfect poliovirus and rotavirus solutions. Biotechnol Bioeng 108(3):720-723.
13. Larson AM, Oh HS, Knipe DM, Klibanov AM. 2013. Decreasing herpes simplex viral infectivity in solution by surface-immobilized and suspended N, N-dodecyl, methyl-polyethylenimine. Pharm Res 30(1):25-31.
14. Park D, Wang J, Klibanov AM. 2008. One-step, painting-like coating procedures to make surfaces highly and permanently bactericidal. Biotechnol Prog 22(2):584-589.
15. Riordan J. 2005. Breastfeeding and human lactation, 3rd edition. Sudbury, MA USA: Jones and Bartlett Publishers Inc. p 200-201.