Opportunities and barriers to establishing a cell therapy programme in South Africa

Stem Cell Research and Therapy

Volumn 4, Issue 5, 2013, Pages

  Jackson, Carlo Stephan ^a   Pepper, Michael S ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; GOVERNMENT REGULATION; HEALTH CARE COST; HEALTH CARE PLANNING; HEALTH PROGRAM; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; MARKETING; MEDICAL EDUCATION; MEDICAL ETHICS; MEDICOLEGAL ASPECT; MESENCHYMAL STEM CELL TRANSPLANTATION; PERSONNEL SHORTAGE; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW; SOUTH AFRICA; STEM CELL TRANSPLANTATION; TISSUE REGENERATION;

EID: 84878383607     PISSN: None     EISSN: 17576512     Source Type: Journal    
DOI: 10.1186/scrt204     Document Type: Review

References (69)

1. The global competitiveness report. [ http://www.weforum.org/reports/ global-competitiveness-report-2011-2012 ]
2. Medical Research Council of the United Kingdom, A Strategy for UK Regenerative Medicine London 2012
3. Human Cells, Tissues, and Cellular and Tissue-Based Products Regulations. 21 C.F.R., Part 1271 Washington: U.S. Government printing office 2012
4. Department of Health, White Paper for the Transformation of the Health System in South Africa Pretoria 1997
5. Department of Health, Strategic Priorities for the National Health System, 2004-2009 Pretoria 2004 21090018
6. Bell C, Devarajan S, Gersbach H, The Long-run Economic Costs of AIDS: Theory and an Application to South Africa Paris: UNESCO 2003 1 118
7. The economic impact of AIDS in South Africa. Bollinger L, Stover J, [ http://www.policyproject.com/pubs/SEImpact/southafr.pdf ]
8. World Health Organization, Global Status Report on Noncommunicable Diseases 2010 Geneva: WHO 2011 1 176
9. Regenerative medicine and tissue engineering: contribution of stem cells in organ transplantation. Chhabra P, Mirmira RG, Brayman KL, Regen Med 2009 14 46 50
10. UK Stem Cell Initiative, Report & Recommendations of the UK Stem Cell Initiative London: Department of Health 2005 1 122 23710483
11. Price Waterhouse Coopers, Biotech Reinvented: Where Do You Go From Here? Sinninghill 2010
12. Current state of stem cell research and its application in South Africa. [ http://embrybros.wordpress.com/2011/04/06/current-state-of-stem-cell-research- and-its-application-in-south-africa/ ]
13. South African bone marrow registry annual general meeting. [ http://www.sabmr.co.za/agm2008report.pdf ]
14. Netcells: stem cell therapy. [ http://www.netcells.co.za/therapy- introduction.php ]
15. Erasmus G, Nkau DJ, Towards a 10-year Review of the Population Policy Implementation in South Africa (1998-2008) Pretoria: Government Communication and Information System 2009 1 66
16. World Health Organization, The Global Burden of Disease Geneva: WHO 2004 1 160
17. The role of autologous stem cell transplantation in the treatment of diffuse large B-cell lymphoma. Gunnellini M, Emili R, Coaccioli S, Liberati AM, Advin Hematol 2012 2012 1 10
18. Review hematopoietic-stem-cell-based gene therapy for HIV disease. H-peter K, Jerome KR, Deeks SG, Mccune JM, Stem Cell 2012 10 137 147
19. Mesenchymal stem cells for cardiac regeneration: translation to bedside reality. Elnakish MT, Hassan F, Dakhlallah D, Marsh CB, Alhaider IA, Khan M, Stem Cells Int 2012 2012 1 14
20. Mesenchymal stem cells for the treatment of diabetes. Pileggi A, Diabetes 2012 61 1355 1356 10.2337/db12-0355 22618774
21. Technology, institutions, and innovation systems. Nelson RR, Nelson K, Res Policy 2002 31 265 272 10.1016/S0048-7333(01)00140-8
22. Introduction: promoting global health through biotechnology. Thorsteinsdóttir H, Quach U, Martin DK, Daar AS, Singer PA, Nat Biotechnol 2004 22 3 7 10.1038/nbt0104-3 14704685
23. ClinicalTrials.gov. [ http://www.clinicaltrials.gov ]
24. BlueCross BlueShield of North Carolina, Corporate Medical Policy Autologous Fat Grafting to the Breast 'Notification' Durham 2012
25. In vitro expansion of chondrocytes. Melero-Martin JM, Al-Rubeai M, Topics in Tissue Engineering, Volume 3 Oulu, Finland: Biomaterials and Tissue Engineering Group, Ashammakhi N, Reis R, Chielline E, 2007 1 37
26. Cartilage repair: what's the right combination? Stuart M, Start-up 2009 14 1 9
27. Stem cell therapy: a new treatment for burns? Arno A, Smith AH, Blit PH, Shehab MA, Gauglitz GG, Jeschke MG, Pharmaceuticals 2011 4 1355 1380 10.3390/ph4101355
28. Review series repairing skeletal muscle: regenerative potential of skeletal muscle stem cells. Tedesco FS, Dellavalle A, Diaz-manera J, Messina G, Cossu G, J Clin Investig 2010 120 1 9
29. Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study. Elliott MJ, Coppi PD, Speggiorin S, Roebuck D, Butler CR, Samuel E, Crowley C, Mclaren C, Fierens A, Vondrys D, Cochrane L, Jephson C, Janes S, Beaumont NJ, Cogan T, Bader A, Seifalian AM, Hsuan JJ, Lowdell MW, Birchall MA, Lancet 2012 380 994 1000 10.1016/S0140-6736(12)60737-5 22841419
30. European Commission, Establishment of Institutional Control on the Safety and Quality of Human Tissues and Cells Used for Transplantation-Development of a National Centre for Tissue and Cell Banking Warsaw 2004
31. A public cord blood bank for South Africa? Crookes R, Toit E, Oudshoorn M, [ http://www.cips.up.ac.za ]
32. Ethical and regulatory issues surrounding umbilical cord blood banking in South Africa. Chima SC, Mamdoo F, S Afr J Bioethics Law 2011 4 79 84
33. Letter: regaining perspective on stem cells. Pepper MS, S Afr Fam Pract 2010 52 2010 2010
34. Kahn M, Blankley W, Rasigan M, Pogue T, Vijay R, Gabriel C, du Marissa T, Flight of the Flamingos: A Study on the Mobility of R&D Workers Cape Town: HSRC Publishers 2004 1 74
35. Department of Labor South Africa, The Shortage of Medical Doctors in South Africa Pretoria 2007
36. Tackling the roots of the brain drain. [ http://www.scidev.net/ ]
37. Rogerson C, Medical Recruits: The Temptation of South African Health Care Professionals Cape Town: South African Migration Project 45 2007 1 52
38. Government wakes up to flight of health workers. [ http://www.irinnews. org/printreport.aspx?reportid=39849 ]
39. Health personnel in Southern Africa: confronting maldistribution and brain drain. [ http://ww.medact.org/content/health/documents/brain-drain/ Padarath%20et%20al.%20-%20Medact-HST-Equient.pdf ]
40. The macroeconomic impact of skilled emigration from South Africa: a CGE analysis. Bohlman HR, [ http://www.econrsa.org/publications/working-papers/ macroeconomic-impact-skilled-emigration-south-africa-cge-analysis ]
41. Accelerated and shared growth initiative for South Africa annual report 2007. Accelerated and Shared Growth Initiative for South Africa, [ http://www.info.gov.za/view/DownloadFileAction?id=80162 ]
42. Department of Health, Employment of Foreign Health Professionals in the South African Health Sector Pretoria 2010
43. Great expectations: the state of biotechnology research and development in South Africa. Gastrow M, Journal of Biotechnology 2008 7 342 348 (Pubitemid 351354575)
44. Perceived pros and cons of the intellectual property rights from Publicly Financed Research and Development Act. Moore R, [ http://www. freemarketfoundation.com/publications/rory-moore-perceived-pros-and-cons ]
45. Organisation for Economic Co-operation and Development, Reviews of innovation policy South Africa: OECD 2007
46. Intellectual property rights Act, 2008. South African Government, Government Gazette 2008 522 1 20 Green Gazette SA (Pty) Ltd: Randburg
47. The impact of intellectual property rights from publicly financed research and development on governance mode decisions for research alliances. Staphorst L, PhD thesis University of Pretoria, Gordon Institute of Business Science 2010
48. The challenges of starting up a biotech company in South Africa. Sherwin H, [ http://www.biosa.org.za/pdfs/heathersherwin.pdf ]
49. Human Sciences Research Council, 2008/2009 National Survey of Research & Experimental Development Cape Town 2011 23379804
50. Technology Innovation Agency, Annual Report 2011/2012 Pretoria 2012
51. Small but tenacious: South Africa's health biotech sector. Al-bader S, Frew SE, Essajee I, Liu VY, Daar AS, Singer PA, Nat Biotechnol 2009 27 427 445 10.1038/nbt0509-427 19430446
52. The South African bone marrow registry-role in providing unrelated donors for allogeneic stem cell transplantation. du Toit ED, Schlophoff T, Borrill V, Contin Med Educ 2012 30 293 294
53. Visible felt leadership: building a truly sustainable safety culture. American A, A Magazine 2012 10 1 34
54. The influence of religion on organ donation and transplantation among the black Caribbean and black African population-a pilot study in the United Kingdom. Davis C, Ethnicity Dis 2006 16 281 285 (Pubitemid 46959281)
55. Department of Science and Technology, National Biotechnology Audit Pretoria 2007
56. Cell-based therapy-navigating troubled waters. Pepper MS, Stem Cells 2010 100 1 2
57. Stem cell tourism in South Africa: the legal position. Mahomed S, Slabbert MN, S Afr Jof Bioethics Law 2012 5 69 73
58. The stem cell regulatory environment in South Africa-cause for concern. Pepper MS, PLoS Med 2009 99 505 507
59. Regulatory crackdown on stem cell therapy: what would the position be in South Africa? Jordaan DW, S Afr Med J 2012 102 219 220 22464500
60. Partial relief from the regulatory vacuum involving human tissues through enactment of chapter 8 of the National Health Act and regulations thereto. Pepper MS, S Afr Med J 2012 102 1 2
61. FDA challenges stem-cell clinic. Ledford H, Nat News 2010 466 909 10.1038/466909a
62. Fulton BD, Felton MC, Pareja C, Potischman A, Scheffler RM, Coverage, cost-control mechanisms, and financial risk-sharing alternatives of high-cost health care technologies Berkeley: California Institute for Regenerative Medicine 2009 1 36
63. In-depth analysis of the general household survey data. Lehohla P, Stat S Afr 2009 2 1 50
64. Research and Information Department, The Relevance of the Biotechnology Industry to South Africa's Healthcare Sector Sandton 2007 22683498
65. Department of Science and Technology, Major International Biotechnology Research Laboratory Opens Its Doors in South Africa Pretoria 2007
66. An example of international scientific cooperation: the international centre for genetic engineering and biotechnology. Ripandelli D, [ http://international.asm.md/files/cei/241008/DRipandelli241008.pdf ]
67. Global Biotech Lab Opens in SA-SouthAfrica.info. [ http://www. southafrica.info/about/science/icgeb-110907.htm ]
68. South Africa-blazing a trail for African biotechnology. Motari M, Quach U, Thorsteinsdóttir H, Martin DK, Daar AS, Singer PA, Nat Biotechnol 2004 22 37 41 10.1038/nbt0104-37 14704700 (Pubitemid 38057950)
69. Banning private stem cell banks: a human rights analysis. Jordaan DW, Woodrow C, Pepper MS, S Afr J Human Rights 2009 25 126 151