Breen et al. reply

Nature

Volumn 497, Issue 7451, 2013, Pages

  Breen, Michael S ^a   Kemena, Carsten ^b,c   Vlasov, Peter K ^b,c   Notredame, Cedric ^b,c   Kondrashov, Fyodor A ^b,c,d  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^c UNIVERSITAT POMPEU FABRA   (Spain)

^d INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID;

ALLELE; ARABIDOPSIS THALIANA; CLADISTICS; CYANOBACTERIUM; EPISTASIS; GENE INTERACTION; GENE LOCUS; GENETIC SELECTION; GENOTYPE PHENOTYPE CORRELATION; MOLECULAR EVOLUTION; NONHUMAN; NOTE; PHYLOGENY; PRIORITY JOURNAL; SEQUENCE ALIGNMENT;

EID: 84878383073     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12220     Document Type: Note

References (8)

1. Kondrashov, F. A. & Kondrashov, A. S. Multidimensional epistasis and the disadvantage of sex. Proc. Natl Acad. Sci. USA 98, 12089-12092 (2001).
2. Breen, M. S., Kemena, C., Vlasov, P. K., Notredame, C. & Kondrashov, F. A. Epistasis as the primary factor in molecular evolution. Nature 490, 535-538 (2012).
3. McCandlish, D. M., Rajon, E., Shah, P., Ding, Y.& Plotkin, J. B. The role of epistasis in protein evolution. Nature 497, E1-E2 (2013).
4. Kondrashov, A. S., Povolotskaya, I. S., Ivankov, D. N. & Kondrashov, F. A. Rate of sequence divergence under constant selection. Biol. Direct 5, 5 (2010).
5. Povolotskaya, I. S.&Kondrashov, F. A. Sequence space and the ongoing expansion of the protein universe. Nature 465, 922-926 (2010).
6. McVean, G. & Charlesworth, B. A population geneticmodel for the evolution of synonymous codonusage:patterns and predictions.Genet. Res. 74, 145-158(1999).
7. Kondrashov, F. A., Ogurtsov, A. Y. & Kondrashov, A. S. Selection in favor of nucleotides G and C diversifies evolution rates and levels of polymorphism at mammalian synonymous sites. J. Theor. Biol. 240, 616-626 (2006).
8. Kimura, M. The role of compensatory neutral mutations in molecular evolution. J. Genet. 64, 7-19 (1985).