Activation of minority-variant Plasmodium vivax hypnozoites following artesunate + amodiaquine treatment in a 23-year old man with relapsing malaria in Antananarivo, Madagascar

Malaria Journal

Volumn 12, Issue 1, 2013, Pages

  Andrianaranjaka, Voahangy ^a   Lin, Jessica T ^b   Golden, Christopher ^c,d   Juliano, Jonathan J ^b   Randrianarivelojosia, Milijaona ^a  

^a INSTITUT PASTEUR DE MADAGASCAR   (Madagascar)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c HARVARD UNIVERSITY   (United States)

^d Madagascar Health and Environmental Research (MAHERY)   (Madagascar)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; AMODIAQUINE PLUS ARTESUNATE; ARTESUNATE; ASAQ; PROTOZOAL PROTEIN; PVMSP 3A PROTEIN; PVMSP1 PROTEIN; UNCLASSIFIED DRUG; AMODIAQUINE, ARTESUNATE DRUG COMBINATION; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; DRUG COMBINATION;

ADULT; ARTICLE; BIOASSAY; BLOOD SAMPLING; CASE REPORT; CHILL; DISEASE DURATION; DISEASE TRANSMISSION; FEVER; GENOTYPE; HEALTH CARE POLICY; HETERODUPLEX TRACKING ASSAY; HISTOPATHOLOGY; HUMAN; HYPNOZOITE; LABORATORY TEST; MADAGASCAR; MALE; MICROSCOPY; PLASMODIUM VIVAX; PLASMODIUM VIVAX MALARIA; POLYMERASE CHAIN REACTION; RELAPSE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SPOROZOITE; DRUG COMBINATION; DRUG EFFECTS; GENETICS; MALARIA, VIVAX; PARASITOLOGY; RECURRENT DISEASE; YOUNG ADULT;

ADULT; AMODIAQUINE; ANTIMALARIALS; ARTEMISININS; DRUG COMBINATIONS; HUMANS; MADAGASCAR; MALARIA, VIVAX; MALE; PLASMODIUM VIVAX; RECURRENCE; SPOROZOITES; YOUNG ADULT;

EID: 84878373692     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-12-177     Document Type: Article

References (13)

1. Modeling Plasmodium vivax: Relapses, treatment, seasonality, and G6PD deficiency. Chamchod F, Beier JC, J Theor Biol 2012 316C 25 34
2. Relapses of Plasmodium vivax infection result from clonal hypnozoites activated at predetermined intervals. Chen N, Auliff A, Rieckmann K, Gatton M, Cheng Q, J Infect Dis 2007 195 934 941 10.1086/512242 17330782 (Pubitemid 46452097)
3. Plasmodium vivax isolates from Cambodia and Thailand show high genetic complexity and distinct patterns of P. vivax multidrug resistance gene 1 (pvmdr1) polymorphisms. Lin J, Patel J, Kharabora O, Sattabongkot J, Muth S, Ubalee R, Schuster A, Rogers W, Wongsrichanalai C, Juliano J, Am J Trop Med Hyg 2013 Epub ahead of print
4. Multiple-clone activation of hypnozoites is the leading cause of relapse in Plasmodium vivax infection. de Araujo FC, de Rezende AM, Fontes CJ, Carvalho LH, Alves de Brito CF, PLoS One 2012 7 49871 10.1371/journal.pone.0049871 23185469
5. Low autochtonous urban malaria in Antananarivo (Madagascar). Rabarijaona LP, Ariey F, Matra R, Cot S, Raharimalala AL, Ranaivo LH, Le Bras J, Robert V, Randrianarivelojosia M, Malar J 2006 5 27 10.1186/1475-2875-5-27 16573843 (Pubitemid 44055064)
6. Randomized, multicentre assessment of the efficacy and safety of ASAQ-a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria. Ndiaye JL, Randrianarivelojosia M, Sagara I, Brasseur P, Ndiaye I, Faye B, Randrianasolo L, Ratsimbasoa A, Forlemu D, Moor VA, Traore A, Dicko Y, Dara N, Lameyre V, Diallo M, Djimde A, Same-Ekobo A, Gaye O, Malar J 2009 8 125 10.1186/1475-2875-8-125 19505304
7. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Snounou G, Viriyakosol S, Zhu XP, Jarra W, Pinheiro L, do Rosario VE, Thaithong S, Brown KN, Mol Biochem Parasitol 1993 61 315 320 10.1016/0166-6851(93)90077-B 8264734
8. Polymorphism at the merozoite surface protein-3alpha locus of Plasmodium vivax: global and local diversity. Bruce MC, Galinski MR, Barnwell JW, Snounou G, Day KP, Am J Trop Med Hyg 1999 61 518 525 10548283 (Pubitemid 29506329)
9. Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea. Koepfli C, Ross A, Kiniboro B, Smith TA, Zimmerman PA, Siba P, Mueller I, Felger I, PLoS Negl Trop Dis 2011 5 1424 10.1371/journal.pntd.0001424 22206027
10. Individual Plasmodium vivax msp1 variants within polyclonal P. vivax infections display different propensities for relapse. Lin JT, Juliano JJ, Kharabora O, Sem R, Lin FC, Muth S, Menard D, Wongsrichanalai C, Rogers WO, Meshnick SR, J Clin Microbiol 2012 50 1449 1451 10.1128/JCM.06212-11 22205791
11. Relapse. White NJ, Imwong M, Adv Parasitol 2012 80 113 150 23199487
12. Plasmodium vivax dhfr and dhps mutations in isolates from Madagascar and therapeutic response to sulphadoxine-pyrimethamine. Barnadas C, Tichit M, Bouchier C, Ratsimbasoa A, Randrianasolo L, Raherinjafy R, Jahevitra M, Picot S, Ménard D, Malar J 2008 7 35 10.1186/1475-2875-7-35 18302746 (Pubitemid 351417047)
13. Epidemiological situation of malaria in Madagascar: baseline data for monitoring the impact of malaria control programmes using serological markers. Razakandrainibe R, Thonier V, Ratsimbasoa A, Rakotomalala E, Ravaoarisoa E, Raherinjafy R, Andrianantenaina H, Voahanginirina O, Rahasana TE, Carod JF, Domarle O, Ménard D, Acta Trop 2009 111 160 167 10.1016/j.actatropica. 2009.04.007 19376076