Single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection at Bugando Medical Centre in Mwanza, Tanzania: A randomized, equivalence, controlled trial

BMC Pregnancy and Childbirth

Volumn 13, Issue , 2013, Pages

  Lyimo, Fadhili M ^a,b   Massinde, Anthony N ^a,b   Kidenya, Benson R ^a   Konje, Eveline T ^a   Mshana, Stephen E ^a  

^a CATHOLIC UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^b Bugando Medical Centre   (Tanzania)

Author keywords

Gentamicin; Metronidazole; Mwanza; Post caesarean infection; Tanzania

Indexed keywords

GENTAMICIN; METRONIDAZOLE;

ARTICLE; CESAREAN SECTION; CONTROLLED STUDY; DRUG DOSE COMPARISON; FOLLOW UP; HUMAN; RANDOMIZED CONTROLLED TRIAL; SURGICAL INFECTION; TANZANIA; TREATMENT OUTCOME;

ADULT; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIBIOTIC PROPHYLAXIS; CESAREAN SECTION; DRUG THERAPY, COMBINATION; EMERGENCIES; FEMALE; GENTAMICINS; HUMANS; INTENTION TO TREAT ANALYSIS; METRONIDAZOLE; PREGNANCY; SURGICAL WOUND INFECTION; TANZANIA; YOUNG ADULT;

EID: 84878373683     PISSN: None     EISSN: 14712393     Source Type: Journal    
DOI: 10.1186/1471-2393-13-123     Document Type: Article

References (38)

1. Lang C, King J. Maternal mortality in the United States. Best Pract Res Clin Obstetrics Gynaecology 2008, 22:517-531.
2. Mbaruku G, Bergström S. Reducing maternal mortality in Kigoma, Tanzania. Health Policy Plan 1995, 10:71-78. 10.1093/heapol/10.1.71, 10141624.
3. AbouZahr C. Global burden of maternal death and disability. Br Med Bull 2003, 67:1-11. 10.1093/bmb/ldg015, 14711750.
4. Henderson E, Love E. Incidence of hospital-acquired infections associated with caesarean section. J Hosp Infect 1995, 29:245-255. 10.1016/0195-6701(95)90271-6, 7658004.
5. Liu S, Liston R, Joseph K, Heaman M, Sauve R, Kramer M. Maternal mortality and severe morbidity associated with low-risk planned caesarean delivery versus planned vaginal delivery at term. CMAJ 2007, 176:455-460. 1800583, 17296957.
6. Burrows L, Meyn LA, Weber AM. Maternal morbidity associated with vaginal versus cesarean delivery. Obstet Gynecol 2004, 103:907-912. 10.1097/01.AOG.0000124568.71597.ce, 15121564.
7. Hebert P, Reed G, Entman SS, Mitchel EF, Berg C, Griffin MR. Serious maternal morbidity after childbirth: prolonged hospital stays and readmissions. Obstet Gynecol 1999, 94:942-947. 10.1016/S0029-7844(99)00419-6, 10576180.
8. Smaill F, Hofmeyr GJ. Antibiotic prophylaxis for cesarean section. Cochrane Database Syst Rev 2002, 3:CD000933.
9. Ehrenkranz NJ, Blackwelder WC, Pfaff SJ, Poppe D, Yerg DE, Kaslow RA. Infections complicating low-risk cesarean sections in community hospitals: efficacy of antimicrobial prophylaxis. Am J Obstet Gynecol 1990, 162:337-343. 10.1016/0002-9378(90)90381-G, 2309812.
10. Kristensen GB, Beiter EC, Mather O. Single-dose cefuroxime prophylaxis in non-elective cesarean section. Acta Obstet Gynecol Scand 1990, 69:497-500. 10.3109/00016349009013325, 2126657.
11. Hopkins L, Smaill F. Antibiotic prophylaxis regimens and drugs for cesarean section. Cochrane Database Syst Rev 2000, 1:CD001136.
12. Donowitz LG, Norris SM. The efficacy of antibiotic prophylaxis in the prevention of post-cesarean section endometritis. Infect Control 1985, 6:189-193.
13. Arianpour N, Safari A, Hatami F. Bacteria isolated from postpartum infection. J Fam Reprod Health 2009, 3:63-66.
14. Kayihura V, Osman NB, Bugalho A, Bergström S. Choice of antibiotics for infection prophylaxis in emergency cesarean sections in low-income countries: a cost-benefit study in Mozambique. Acta Obstet Gynecol Scand 2003, 82:636-641. 10.1034/j.1600-0412.2003.00205.x, 12790845.
15. Anguzu J, Olila D. Drug sensitivity patterns of bacterial isolates from septic post-operative wounds in a regional referral hospital in Uganda. Afr Health Sci 2007, 7:148-154. 2269712, 18052868.
16. Zelenitsky S, Ariano R, Harding G, Silverman R. Antibiotic pharmacodynamics in surgical prophylaxis:An association between intraoperative antibiotic concentrations and efficacy. Antimicrob Agents Chemother 2002, 46:3026-3030. 10.1128/AAC.46.9.3026-3030.2002, 127433, 12183263.
17. Costantine MM, Rahman M, Ghulmiyah L, Byers BD, Longo M, Wen T, Hankins GD, Saade GR. Timing of perioperative antibiotics for cesarean delivery: a metaanalysis. Am J Obstet Gynecol 2008, 199:301.e301-301.e306.
18. Sullivan SA, Smith T, Chang E, Hulsey T, Vandorsten JP, Soper D. Administration of cefazolin prior to skin incision is superior to cefazolin at cord clamping in preventing postcesarean infectious morbidity: a randomized, controlled trial. Am J Obstet Gynecol 2007, 196:455.e451-455.e455.
19. ACOG Committee Opinion No. 465: Antimicrobial Prophylaxis for Cesarean Delivery: Timing of Administration. Obstet Gynecol 2010, 116:791-792. 10.1097/AOG.0b013e3181f68086, 20733474, ACOG.
20. Boselli E, Bouvet L, Rimmelé T, Chassard D, Allaouchiche B. Antimicrobial prophylaxis for caesarean delivery: before or after cord clamping? A meta-analysis. Ann Fr Anesth Reanim 2009, 28:855-867. 10.1016/j.annfar.2009.07.087, 19767169.
21. Lamont R, Sobel J, Kusanovic J, Vaisbuch E, Mazaki-Tovi S, Kim S, Uldbjerg N, Romero R. Current debate on the use of antibiotic prophylaxis for caesarean section. BJOGy 2011, 118:193-201.
22. Owens SM, Brozanski BS, Meyn LA, Wiesenfeld HC. Antimicrobial prophylaxis for cesarean delivery before skin incision. Obstet Gynecol 2009, 114:573-579. 10.1097/AOG.0b013e3181b490f1, 19701037.
23. Shakya A, Sharma J. Comparison of single versus multiple doses of antibiotic prophylaxis in reducing post-elective Caesarean section infectious morbidity. Kathmandu Univ Med J (KUMJ) 2010, 8:179-184.
24. Saltzman DH, Eron LJ, Tuomala RE, Protomastro LJ, Sites JG. Single-dose antibiotic prophylaxis in high-risk patients undergoing cesarean section. A comparative trial. J Reprod Med 1986, 31:709-712.
25. Zelenitsky S, Silverman R, Duckworth H, Harding G. A prospective, randomized, double-blind study of single high dose versus multiple standard dose gentamicin both in combination with metronidazole for colorectal surgical prophylaxis. J Hosp Infect 2000, 46:135-140. 10.1053/jhin.2000.0814, 11049707.
26. Bugando Health management and information systems [MTUHA] 2010, Mwanza: Bugando Medical Centre, Unpublished, Bugando.
27. Lyimo FM, Massinde AN, Kidenya BR, Konje E, Mshana SE. Efficacy of single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection: study protocol for a randomized controlled trial. Trials 2012, 13:89. 10.1186/1745-6215-13-89, 3475059, 22720689.
28. Blackwelder W. "Proving the null hypothesis" in clinical trials. Control Clin Trials 1982, 3:345-353. 10.1016/0197-2456(82)90024-1, 7160191.
29. Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC Definitions of Nosocomial Surgical Site Infections, 1992: A Modification of CDC Definitions of Surgical Wound Infections. Infect Control Hosp Epidemiol 1992, 13:606-608. 10.1086/646436, 1334988.
30. Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for Prevention of Surgical Site Infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. Am J Infect Control 1999, 27:97-132. quiz 133-134; discussion 196, 10.1016/S0196-6553(99)70088-X, 10196487.
31. Draft guideline for the prevention of surgical site infection, 1998--CDC. Notice. Fed Regist 1998, 63:33168-33192.
32. Consensus paper on the surveillance of surgical wound infections. The Society for Hospital Epidemiology of America; The Association for Practitioners in Infection Control; The Centers for Disease Control; The Surgical Infection Society. Infect Control Hosp Epidemiol 1992, 13:599-605. .
33. Slobogean GP, O'Brien PJ, Brauer CA. Single-dose versus multiple-dose antibiotic prophylaxis for the surgical treatment of closed fractures. Acta Orthop 2010, 81:256-262. 10.3109/17453671003587119, 2895348, 20148647.
34. Radder CM, Van Eps LW S, Kagie MJ. Antibiotic prophylaxis in surgery: summary of a Swedish-Norwegian Consensus Conference [Sickle cell anemia during pregnancy]. Scand J Infect Dis 1998, 30:547-557.
35. Mawalla B, Mshana S, Chalya P, Imirzalioglu C, Mahalu W. Predictors of surgical site infections among patients undergoing major surgery at Bugando Medical Centre in Northwestern Tanzania. BMC Surg 2010, 11:21.
36. Mpogoro FJ. Predictors of surgical site infections among patients undergoing Caesarean section at Bugando Medical Centre in Northwestern Tanzania: Dissertation for Master of Medicine in Obstetric and Gynaecology 2012, Mwanza: Catholic University of Health and Allied Sciences.
37. WHO The World Health Report 2006: working together for health 2006, http://www.who.int/entity/whr/2006/whr06_en.pdf, WHO.
38. Ministry of Health and social welfare of Tanzania: Health sector strategic plan III- July 2009 - June 2015 2008, 26-27.