A stereological study of the volume-weighted volume and of the relative volume of the nucleus of normal and preneoplastic hepatocytes in a trout model of hepatocarcinogenesis

Experimental and Toxicologic Pathology

Volumn 65, Issue 5, 2013, Pages 623-630

  Santos, Marta ^a,b   Monteiro, Rogério A F ^a,b   Rocha, Eduardo ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Fish; Foci of cellular alteration; Hepatocarcinogenesis; Nuclear volume; Stereology; Trout

Indexed keywords

ESTRADIOL; METHYLNITRONITROSOGUANIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN TROUT; CELL DENSITY; CELL NUCLEUS; CELL STRUCTURE; CELL VOLUME; CELLULAR PARAMETERS; CONTROLLED STUDY; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CELL; LIVER SINUSOID; MICROSCOPY; MOLECULAR IMAGING; NONHUMAN; PRECANCER; QUANTITATIVE STUDY; STEREOLOGY; THREE DIMENSIONAL IMAGING;

ANIMALS; CELL NUCLEUS; CELL NUCLEUS SIZE; COCARCINOGENESIS; ESTRADIOL; HEPATOCYTES; LIVER NEOPLASMS, EXPERIMENTAL; METHYLNITRONITROSOGUANIDINE; PRECANCEROUS CONDITIONS; TROUT;

ANIMALIA; PISCES; SALMO TRUTTA; SALMONIDAE;

EID: 84878361414     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2012.07.001     Document Type: Article

References (31)

1. Bailey G.S., Williams D.E., Hendricks J.D. Fish models for environmental carcinogenesis: the rainbow trout. Environmental Health Perspectives 1996, 104:5-21.
2. Bannasch P. Pre-neoplastic lesions as end points in carcinogenicity testing. I-hepatic preneoplasia. Carcinogenesis 1986, 7:689-695.
3. Blazer V.S., Fournie J.W., Wolf J.C., Wolfe M.J. Diagnostic criteria for proliferative hepatic lesions in brown bullhead Ameiurus nebulosus. Diseases of Aquatic Organisms 2006, 72:19-30.
4. Boorman G.A., Botts S., Bunton T.E., Fournie J.W., Harshbarger J.C., Hawkins W.E., et al. Diagnostic criteria for degenerative, inflammatory, proliferative nonneoplastic and neoplastic liver lesions in medaka (Oryzias latipes): consensus of a National Toxicology Program Pathology Working Group. Toxicologic Pathology 1997, 25:202-210.
5. Brown-Peterson N.J., Krol R.M., Zhu Y., Hawkins W.E. N-nitrosodiethylamine initiation of carcinogenesis in Japanese medaka (Oryzias latipes): hepatocellular proliferation, toxicity, and neoplastic lesions resulting from short term, low level exposure. Toxicological Sciences 1999, 50:186-194.
6. Broxup B.R., Valli V.E., Losos G.L., Percy D.H., Farber E., McMillan I. Morphometric evaluation of hepatocellular proliferative lesions in the rat liver. Toxicologic Pathology 1988, 16:401-417.
7. Carlson D.B., Williams D.E., Spitsbergen J.M., Ross P.F., Bacon C.W., Meredith F.I., et al. Fumonisin B1 promotes aflatoxin B1 and N-methyl-N'-nitro-nitrosoguanidine-initiated liver tumors in rainbow trout. Toxicology and Applied Pharmacology 2011, 172:29-36.
8. Feist S.W., Lang T., Stentiford G.D., Köhler A. Biological effects of contaminants: use of liver pathology of the European flatfish dab (Limanda limanda L.) and flounder (Platichthys flesus L.) for monitoring. ICES Techniques in Marine Environmental Sciences 2004, 38:38-42.
9. Freere R.H., Weibel E.R. Stereological techniques in microscopy. Journal of the Royal Microscopical Society 1966, 87:25-34.
10. Fujikawa K., Matsui Y., Kobayashi T., Miura K., Oka H., Fukuzawa S., et al. Predicting pathological stage of localized prostate cancer using volume weighted mean nuclear volume. Journal of Urology 2000, 164:1587-1590.
11. Fujikawa K., Sasaki M., Aoyama T., Itoh T., Yoshida O. Prognostic criteria in patients with prostate cancer: correlation with volume weighted mean nuclear volume. Journal of Urology 1995, 154:2123-2137.
12. Gundersen H.J., Jensen E.B. Stereological estimation of the volume-weighted mean volume of arbitrary particles observed on random sections. Journal of Microscopy 1985, 138:127-142.
13. Hendricks J.D., Meyers T.R., Shelton D.W. Histological progression of hepatic neoplasia in rainbow trout (Salmo gairdneri). National Cancer Institute Monographs 1984, 65:321-336.
14. Hendricks J.D., Shelton D.W., Loveland P.M., Pereira C.B., Bailey G.S. Carcinogenicity of dietary dimethylnitrosomorpholine N-methyl-N'-nitro-N-nitrosoguanidine, and dibromoethane in rainbow trout. Toxicologic Pathology 1995, 23:447-457.
15. Hinton D., Couch J. Architectural pattern, tissue and cellular morphology in livers of fishes: relationship to experimentally-induced neoplastic responses. EXS 1998, 86:141-164.
16. Hosmer D.W., Lemeshow S. Applied logistic regression 2000, Wiley Series on Probability and Statistics, New York, USA.
17. Howard C.V., Reed M.G. Estimation of component volume and volume fraction. Unbiased stereology 1998, 55-68. Bios Scientific Publishers, Oxford, United Kingdom. C.V. Howard, M.G. Reed (Eds.).
18. Jack E.M., Bentley P., Bieri F., Muakkassah-Kelly S.F., Stäubli W., Suter J., et al. Increase in hepatocyte and nuclear volume and decrease in the population of binucleated cells in preneoplastic foci of rat liver: a stereological study using the nucleator method. Hepatology 1990, 11:286-297.
19. Köhler A., Ellesat K. Nuclear changes in blood, early liver anomalies and hepatocellular cancers in flounder (Platichthys flesus L.) as prognostic indicator for a higher cancer risk?. Marine Environment Research 2008, 66:149-150.
20. Mandarim-de-Lacerda C.A. Stereological tools in biomedical research. Anais da Academia Brasileira de Ciencias 2003, 75:469-486.
21. Mayer D., Forstner K., Kopplow K. Induction and modulation of hepatic preneoplasia and neoplasia in the rat by dehydroepiandrosterone. Toxicologic Pathology 2003, 31:103-112.
22. Myers M.S., Landahl J.T., Krahn M.M., McCain B.B. Relationships between hepatic neoplasms and related lesions and exposure to toxic chemicals in marine fish from the U.S. West Coast. Environmental Health Perspectives 1991, 90:7-15.
23. Orner G.A., Hendricks J.D., Arbogast D., Williams D.E. Modulation of N-methyl-N'-nitro-nitrosoguanidine multiorgan carcinogenesis by dehydroepiandrosterone in rainbow trout. Toxicology and Applied Pharmacology 1996, 141:548-554.
24. Rocha E., Monteiro R.A.F., Pereira C.A. Liver of the brown trout, Salmo trutta (Teleostei Salmonidae): a stereological study at light and electron microscopic levels. Anatomical Record 1997, 247:317-328.
25. Rocha E., Rocha M.J., Galante M.H., Silva M.W., Monteiro R.A.F. The hepatocytes of the brown trout (Salmo trutta f. fario): a stereological study of their number and size during the breeding cycle. Ichthyological Research 2009, 56:43-54.
26. Sørensen F.B. Quantitative analysis of nuclear size for objective malignancy grading: a review with emphasis on new unbiased stereologic methods. Laboratory Investigation 1992, 66:4-23.
27. Steiner A., Binder M., Mossbacher U., Wolff K., Pehamberger H. Estimation of the volume-weighted mean nuclear volume discriminates Spitz's nevi from nodular malignant melanomas. Laboratory Investigation 1994, 70:381-385.
28. Stentiford G.D., Viant M.R., Ward D.G., Johnson P.J., Martin A., Wenbin W., et al. Liver tumors in wild flatfish: a histopathological, proteomic, and metabolomic study. OMICS 2005, 9:281-299.
29. Stine C.B., Smith D.L., Vogelbein W.K., Harshbarger J.C., Gudla P.R., Lipsky M.M., et al. Morphometry of hepatic neoplasms and altered foci in the mummichog, Fundulus heteroclitus. Toxicologic Pathology 2004, 32:375-383.
30. Su Q., Benner A., Hofmann W.J., Otto G., Pichlmayr R., Bannasch P. Human hepatic preneoplasia: phenotypes and proliferation kinetics of foci and nodules of altered hepatocytes and their relationship to liver cell dysplasia. Virchows Archiv 1997, 431:391-406.
31. Xu Y., Pitot H.C. A software package to improve image quality and isolation of objects of interest for quantitative stereology studies of rat hepatocarcinogenesis. Computer Methods and Programs in Biomedicine 2006, 81:236-245.