Why is Pseudomonas aeruginosa a common cause of infection in individuals with cystic fibrosis?

Future Microbiology

Volumn 8, Issue 6, 2013, Pages 697-699

  Gross, Jeremy ^a   Welch, Martin ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

antibiotic resistance; cystic fibrosis; microbial adaptation; Pseudomonas aeruginosa

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR;

BACTERIAL COLONIZATION; BACTERIAL GENOME; CYSTIC FIBROSIS; DNA REPAIR; GENE MUTATION; GRAM NEGATIVE BACTERIUM; HORIZONTAL GENE TRANSFER; HUMAN; INTERNALIZATION; LUNG DISEASE; NONHUMAN; PHAGOCYTOSIS; PLASTICITY; PRIORITY JOURNAL; PROTEIN BINDING; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; REVIEW;

ADAPTATION, PHYSIOLOGICAL; CYSTIC FIBROSIS; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

PSEUDOMONAS AERUGINOSA;

EID: 84878292827     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.13.40     Document Type: Review

References (19)

1. Høiby N. Recent advances in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis. BMC Med. 9, 32 (2011
2. Aaron SD, Ramotar K, Ferris W, et al. Adult cystic fibrosis exacerbations and new strains of Pseudomonas aeruginosa. Am. J. Respir. Crit. Care Med. 169(7), 811-815 (2004 (Pubitemid 38402456)
3. Mathee K, Narasimhan G, Valdes C, et al. Dynamics of Pseudomonas aeruginosa genome evolution. Proc. Natl Acad. Sci. USA 105(8), 3100-3105 (2008 (Pubitemid 351723674)
4. Cramer N, Wiehlmann L, Ciofu O, Tamm S, Høiby N, Tümmler B. Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis. PLoS ONE 7(11), e50731 (2012
5. Boucher RC. Evidence for airway surface dehydration as the initiating event in CF airway disease. J. Intern. Med. 261(1), 5-16 (2007 (Pubitemid 46046468)
6. de Bentzmann S, Roger P, Dupuit F, et al. Asialo GM1 is a receptor for Pseudomonas aeruginosa adherence to regenerating respiratory epithelial cells. Infect. Immun. 64(5), 1582-1588 (1996 (Pubitemid 26129819)
7. Campodónico VL, Gadjeva M, Paradis-Bleau C, Uluer A, Pier GB. Airway epithelial control of Pseudomonas aeruginosa infection in cystic fibrosis. Trends Mol. Med. 14(3), 120-133 (2008
8. Hansen SK, Rau MH, Johansen HK, et al. Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection. ISME J. 6(1), 31-45 (2012
9. Cox MJ, Allgaier M, Taylor B, et al. Airway microbiota and pathogen abundance in age-stratified cystic fibrosis patients. PLoS ONE 5(6), e11044 (2010
10. Bjarnsholt T, Jensen PØ, Fiandaca MJ, et al. Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients. Pediatr. Pulmonol. 44(6), 547-558 (2009
11. Wei Q, Tarighi S, Dötsch A, et al. Phenotypic and genome-wide analysis of an antibiotic-resistant small colony variant (SCV) of Pseudomonas aeruginosa. PLoS ONE 6(12), e29276 (2011
12. Amiel E, Lovewell RR, O'Toole GA, Hogan DA, Berwin B. Pseudomonas aeruginosa evasion of phagocytosis is mediated by loss of swimming motility and is independent of flagellum expression. Infect. Immun. 78(7), 2937-2945 (2010
13. Thomas SR, Ray A, Hodson ME, Pitt TL. Increased sputum amino acid concentrations and auxotrophy of Pseudomonas aeruginosa in severe cystic fibrosis lung disease. Thorax 55(9), 795-797 (2000 (Pubitemid 30660910)
14. Alcalá-Franco B, Montanari S, Cigana C, Bertoni G, Oliver A, Bragonzi A. Antibiotic pressure compensates the biological cost associated with Pseudomonas aeruginosa hypermutable phenotypes in vitro and in a murine model of chronic airways infection. J. Antimicrob. Chemother. 67(4), 962-969 (2012
15. Strateva T, Yordanov D. Pseudomonas aeruginosa -a phenomenon of bacterial resistance. J. Med. Microbiol. 58(9), 1133-1148 (2009
16. Nguyen D, Joshi-Datar A, Lepine F, et al. Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Science 334(6058), 982-986 (2011
17. Alhede M, Bjarnsholt T, Jensen PØ, et al. Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes. Microbiology 155(11), 3500-3508 (2009
18. Ramsey BW, Davies J, McElvaney NG, et al. A CFTR potentiator in patients with cystic gibrosis and the G551D mutation. N. Engl. J. Med. 365(18), 1663-1672 (2011
19. Davies JC, Alton EW. Gene therapy for cystic fibrosis. Proc. Am. Thorac. Soc. 7(6), 408-414 (2010