The atrazine metabolite diaminochlorotriazine suppresses LH release from murine LβT2 cells by suppressing GnRH-induced intracellular calcium transients

Toxicology Research

Volumn 2, Issue 3, 2013, Pages 180-186

  Dooley, Gregory P ^a   Tjalkens, Ronald B ^a   Hanneman, William H ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATRAZINE; GONADORELIN; LUTEINIZING HORMONE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; FLUORESCENCE MICROSCOPY; HORMONE RELEASE; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

MURINAE;

EID: 84878282198     PISSN: 2045452X     EISSN: 20454538     Source Type: Journal    
DOI: 10.1039/c3tx20088d     Document Type: Article

References (24)

1. R. Cooper T. Stoker L. Tyrey J. Goldman W. McElroy Atrazine disrupts the hypothalamic control of pituitary-ovarian function Toxicol. Sci. 2000 53 297 307
2. R. Cooper T. Stoker J. Goldman M. Parrish L. Tyrey Effect of atrazine on ovarian function in the rat Reprod. Toxicol. 1996 10 257 264
3. C. Foradori L. Hinds W. Hanneman M. Legare C. Clay R. Handa Atrazine inhibits pulsatile luteinizing hormone release without altering pituitary sensitivity to a gonadotropin-releasing hormone receptor agonist in female Wistar rats Biol. Reprod. 2009 81 40 45
4. T. Stoker D. Guidici S. Laws R. Cooper The effects of atrazine metabolites on puberty and thyroid function in the male Wistar rat Toxicol. Sci. 2002 67 198 206
5. S. Laws J. Ferrell T. Stoker R. Cooper Pubertal development in female Wistar rats following exposure to propazine and atrazine biotransformation by-products, diamino-S-chlorotriazine and hydroxyatrazine Toxicol. Sci. 2003 76 190 200
6. T. Stoker S. Laws D. Guidici R. Cooper The effect of atrazine on puberty in male Wister rats: and evaluation in the protocol for the assessment of pubertal development and thyroid function Toxicol. Sci. 2000 58 52 59
7. S. Trentacoste A. Friedmann R. Youker C. Breckenridge B. Zirkin Atrazine effects on testosterone levels and androgen-dependent reproductive organs in peripubertal male rats J. Andology. 2001 22 142 148
8. A. Friedmann Atrazine inhibition of testosterone production in rat males following peripubertal exposure Reprod. Toxicol. 2002 16 275 279
9. R. Boyar J. Finkelstein H. Roffwarg S. Kapen E. Weitzman L. Hellman Synchronization of augmented luteinizing hormone secretion with sleep during puberty N. Engl. J. Med. 1972 287 582 586
10. D. Parker H. Judd L. Rossman S. Yen Pubertal sleep-wake patterns of episodic LH, FSH and testosterone release in twin boys J. Clin. Endocrinol. Metab. 1975 40 1099 1109
11. H. Kulin R. Moore S. Santner Circadian rhythms in gonadotropin excretion in prepubertal and pubertal children J. Clin. Endocrinol. Metab. 1976 42 770 773
12. A. Coquelin C. Desjardins Luteinizing hormone and testosterone secretion in young and old male mice Am. J. Physiol. 1982 243 257 263
13. M. Dufau J. Veldhuis F. Fraioli M. Johnson I. Beitins Mode of secretion of bioactive luteinizing hormone in man J. Clin. Endocrinol. Metab. 1983 57 993 1000
14. G. Dooley K. Reardon J. Prenni R. Tjalkens M. Legare C. Foradori J. Tessari W. Hanneman Proteomic analysis of diaminochlorotriazine adducts in wistar rat pituitary glands and L beta T2 rat pituitary cells Chem. Res. Toxicol. 2008 21 844 851
15. A. Tse B. Hille GnRH-induced Ca2+ oscillations and rhythmic hyperpolarizations of pituitary gonadotropes Science 1992 255 462 464
16. Y. Li P. Camacho Ca2+-dependent redox modulation of SERCA 2b by ERp57 J. Cell Biol. 2004 164 35 46
17. P. Thomas P. L. Mellon J. Turgeon D. W. Waring The L beta T2 clonal gonadotrope: a model for single cell studies of endocrine cell secretion Endocrinology 1996 137 2979 2989
18. G. Niswender L. Reichert Jr. A. Midgley A. Nalbandov Radioimmunoassay for bovine and ovine luteinizing hormone Endocrinology 1969 84 1166 1173
19. T. McMullin J. Brzezicki B. Cranmer J. Tessari M. Andersen Pharmacokinetic modeling of disposition and time-course studies with C14-atrazine J. Toxicol. Environ. Health, Part A 2003 66 941 964
20. G. Dooley J. Prenni P. Prentiss B. Cranmer M. Andersen J. Tessari Identification of a novel hemoglobin adduct in Sprague Dawley rats exposed to atrazine Chem. Res. Toxicol. 2006 19 692 700
21. G. Dooley A. Ashley M. Legare R. Handa W. Hanneman Proteomic analysis of diaminochlorotriazine (DACT) adducts in three brain regions of Wistar rats Toxicol. Lett. 2010 199 17 21
22. A. Zapun N. Darby D. Tessier M. Michalak J. Bergeron D. Thomas Enhanced catalysis of ribonuclease B folding by the interaction of calnexin or calreticulin with ERp57 J. Biol. Chem. 1998 273 6009 6012
23. S. High F. Lecomte S. Russell B. Abell J. Oliver Glycoprotein folding in the endoplasmic reticulum: a tale of three chaperones? FEBS Lett. 2000 476 38 41
24. T. Simmen E. Lynes K. Gesson G. Thomas Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM) Biochim. Biophys. Acta 2010 1798 1465 1473