메뉴 건너뛰기




Volumn 73, Issue 6, 2013, Pages 563-574

Pasireotide: A review of its use in Cushing's disease

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPEPTIN; D DIMER; DEXAMETHASONE; HYDROCORTISONE; OCTREOTIDE; PASIREOTIDE; PLACEBO; PROTEIN C; PROTEIN S; SOMATOSTATIN RECEPTOR 5;

EID: 84878281667     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-013-0052-0     Document Type: Review
Times cited : (24)

References (34)
  • 1
    • 47549104969 scopus 로고    scopus 로고
    • Treatment of adrenocorticotropin-dependent Cushing's syndrome: A consensus statement
    • 18413427 10.1210/jc.2007-2734 1:CAS:528:DC%2BD1cXoslyktLo%3D
    • BM Biller AB Grossman PM Stewart, et al. 2008 Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement J Clin Endocrinol Metab 93 7 2454 2462 18413427 10.1210/jc.2007-2734 1:CAS:528:DC%2BD1cXoslyktLo%3D
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.7 , pp. 2454-2462
    • Biller, B.M.1    Grossman, A.B.2    Stewart, P.M.3
  • 2
    • 84865702793 scopus 로고    scopus 로고
    • The burden of Cushing's disease: Clinical and health-related quality of life aspects
    • 22728347 10.1530/EJE-11-1095 1:CAS:528:DC%2BC38XhsVWltLnK
    • RA Feelders SJ Pulgar A Kempel, et al. 2012 The burden of Cushing's disease: clinical and health-related quality of life aspects Eur J Endocrinol 167 3 311 326 22728347 10.1530/EJE-11-1095 1:CAS:528:DC%2BC38XhsVWltLnK
    • (2012) Eur J Endocrinol , vol.167 , Issue.3 , pp. 311-326
    • Feelders, R.A.1    Pulgar, S.J.2    Kempel, A.3
  • 3
    • 17744362051 scopus 로고    scopus 로고
    • Incidence and late prognosis of Cushing's syndrome: A population-based study
    • 11231987 10.1210/jc.86.1.117 1:CAS:528:DC%2BD3MXhtVGnsrs%3D
    • J Lindholm S Juul JO Jorgensen, et al. 2001 Incidence and late prognosis of Cushing's syndrome: a population-based study J Clin Endocrinol Metab 86 1 117 123 11231987 10.1210/jc.86.1.117 1:CAS:528:DC%2BD3MXhtVGnsrs%3D
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.1 , pp. 117-123
    • Lindholm, J.1    Juul, S.2    Jorgensen, J.O.3
  • 4
    • 84874313212 scopus 로고    scopus 로고
    • Management of hyperglycaemia in Cushing's disease: Expert's proposals on the use of pasireotide
    • 23228667 10.1016/j.diabet.2012.10.005 1:CAS:528:DC%2BC38XhvVWjtbvP
    • Y Reznik J Bertherat F Borson-Chazot, et al. 2013 Management of hyperglycaemia in Cushing's disease: expert's proposals on the use of pasireotide Diabetes Metab 39 1 34 41 23228667 10.1016/j.diabet.2012.10.005 1:CAS:528:DC%2BC38XhvVWjtbvP
    • (2013) Diabetes Metab , vol.39 , Issue.1 , pp. 34-41
    • Reznik, Y.1    Bertherat, J.2    Borson-Chazot, F.3
  • 5
    • 0028339489 scopus 로고
    • Morbidity and mortality in Cushing's disease: An epidemiological approach
    • 10.1111/j.1365-2265.1994.tb02486.x 1:STN:280:DyaK2c3ksVSkuw%3D%3D
    • J Etxabe JA Vazquez 1994 Morbidity and mortality in Cushing's disease: an epidemiological approach Clin Endocrinol (Oxf) 40 4 479 484 10.1111/j.1365-2265.1994.tb02486.x 1:STN:280:DyaK2c3ksVSkuw%3D%3D
    • (1994) Clin Endocrinol (Oxf) , vol.40 , Issue.4 , pp. 479-484
    • Etxabe, J.1    Vazquez, J.A.2
  • 6
    • 39049147596 scopus 로고    scopus 로고
    • Late recurrences of Cushing's disease after initial successful transsphenoidal surgery
    • 18056770 10.1210/jc.2007-2013 1:CAS:528:DC%2BD1cXit1Sntrk%3D
    • CG Patil DM Prevedello SP Lad, et al. 2008 Late recurrences of Cushing's disease after initial successful transsphenoidal surgery J Clin Endocrinol Metab 93 2 358 362 18056770 10.1210/jc.2007-2013 1:CAS:528:DC%2BD1cXit1Sntrk%3D
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.2 , pp. 358-362
    • Patil, C.G.1    Prevedello, D.M.2    Lad, S.P.3
  • 7
    • 83555165693 scopus 로고    scopus 로고
    • New treatment guidelines on Cushing's disease
    • doi: 10.3410/M1-64
    • Arnaldi G, Boscaro M. New treatment guidelines on Cushing's disease. F1000 Med Rep. 2009. doi: 10.3410/M1-64.
    • (2009) F1000 Med Rep.
    • Arnaldi, G.1    Boscaro, M.2
  • 8
    • 20244376493 scopus 로고    scopus 로고
    • The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5
    • 15817922 10.1530/eje.1.01876 1:CAS:528:DC%2BD2MXjslansLg%3D
    • LJ Hofland J van der Hoek R Feelders, et al. 2005 The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5 Eur J Endocrinol 152 4 645 654 15817922 10.1530/eje.1.01876 1:CAS:528:DC%2BD2MXjslansLg%3D
    • (2005) Eur J Endocrinol , vol.152 , Issue.4 , pp. 645-654
    • Hofland, L.J.1    Van Der Hoek, J.2    Feelders, R.3
  • 9
    • 84872781330 scopus 로고    scopus 로고
    • Medical treatment of Cushing's disease with pasireotide
    • A Lacroix R Pivonello 2012 Medical treatment of Cushing's disease with pasireotide Eur Endocrinol 8 2 99 104
    • (2012) Eur Endocrinol , vol.8 , Issue.2 , pp. 99-104
    • Lacroix, A.1    Pivonello, R.2
  • 10
    • 84878323695 scopus 로고    scopus 로고
    • European Medicines Agency Accessed 9 Jan 2013
    • European Medicines Agency. Signifor solution for injection: summary of product characteristics. 2012. http://www.ema.europa.eu/docs/en-GB/document- library/EPAR-Product-Information/human/002052/WC500128056.pdf. Accessed 9 Jan 2013.
    • (2012) Signifor Solution for Injection: Summary of Product Characteristics
  • 11
    • 34547464547 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals Corporation Accessed 12 Jan 2013
    • Novartis Pharmaceuticals Corporation. Signifor: full prescribing information. 2012. http://www.pharma.us.novartis.com/product/pi/pdf/signifor. pdf. Accessed 12 Jan 2013.
    • (2012) Signifor: Full Prescribing Information
  • 12
    • 33751532708 scopus 로고    scopus 로고
    • The effects of SOM230 on cell proliferation and adrenocorticotropin secretion in human corticotroph pituitary adenomas
    • 16940446 10.1210/jc.2006-1245 1:CAS:528:DC%2BD28Xht1WhurvL
    • DL Batista X Zhang R Gejman, et al. 2006 The effects of SOM230 on cell proliferation and adrenocorticotropin secretion in human corticotroph pituitary adenomas J Clin Endocrinol Metab 91 11 4482 4488 16940446 10.1210/jc.2006-1245 1:CAS:528:DC%2BD28Xht1WhurvL
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.11 , pp. 4482-4488
    • Batista, D.L.1    Zhang, X.2    Gejman, R.3
  • 13
    • 84867403297 scopus 로고    scopus 로고
    • Multiple once-daily subcutaneous doses of pasireotide were well tolerated in healthy male volunteers: A randomized, double-blind, placebo-controlled, cross-over, phase i study
    • 22527887 10.1007/s12020-012-9668-1 1:CAS:528:DC%2BC38XlvFais7s%3D
    • C Beglinger K Hu Y Wang, et al. 2012 Multiple once-daily subcutaneous doses of pasireotide were well tolerated in healthy male volunteers: a randomized, double-blind, placebo-controlled, cross-over, phase I study Endocrine 42 2 366 374 22527887 10.1007/s12020-012-9668-1 1:CAS:528: DC%2BC38XlvFais7s%3D
    • (2012) Endocrine , vol.42 , Issue.2 , pp. 366-374
    • Beglinger, C.1    Hu, K.2    Wang, Y.3
  • 14
    • 84862084544 scopus 로고    scopus 로고
    • A first-in-man study to evaluate the safety, tolerability, and pharmacokinetics of pasireotide (SOM230), a multireceptor-targeted somatostatin analog, in healthy volunteers
    • 22573933 10.2147/DDDT.S29125 1:CAS:528:DC%2BC38XmsF2qt7c%3D
    • G Golor K Hu M Ruffin, et al. 2012 A first-in-man study to evaluate the safety, tolerability, and pharmacokinetics of pasireotide (SOM230), a multireceptor-targeted somatostatin analog, in healthy volunteers Drug Des Devel Ther 6 71 79 22573933 10.2147/DDDT.S29125 1:CAS:528:DC%2BC38XmsF2qt7c%3D
    • (2012) Drug des Devel Ther , vol.6 , pp. 71-79
    • Golor, G.1    Hu, K.2    Ruffin, M.3
  • 15
    • 84900827014 scopus 로고    scopus 로고
    • An open-label dose-escalation study of once-daily and twice-daily pasireotide in healthy volunteers: Safety, tolerability, and effects on glucose, insulin, and glucagon levels
    • doi: 10.1097/MJT.0b013e31824c3eb4
    • Shenouda M, Maldonado M, Wang Y, et al. An open-label dose-escalation study of once-daily and twice-daily pasireotide in healthy volunteers: safety, tolerability, and effects on glucose, insulin, and glucagon levels. Am J Ther. 2012. doi: 10.1097/MJT.0b013e31824c3eb4.
    • (2012) Am J Ther.
    • Shenouda, M.1    Maldonado, M.2    Wang, Y.3
  • 16
    • 83455162028 scopus 로고    scopus 로고
    • Mechanism and management of hyperglycaemia associated with pasireotide: Results from studies in healthy volunteers [abstract no. P260]
    • 30 Apr 4-May 2011; Rotterdam
    • Henry RR, Mudaliar S, Wetli-Hermosillo K, et al. Mechanism and management of hyperglycaemia associated with pasireotide: results from studies in healthy volunteers [abstract no. P260]. European Congress of Endocrinology; 30 Apr 4-May 2011; Rotterdam.
    • European Congress of Endocrinology
    • Henry, R.R.1    Mudaliar, S.2    Wetli-Hermosillo, K.3
  • 17
    • 77952298716 scopus 로고    scopus 로고
    • Pasireotide alone or with cabergoline and ketoconazole in Cushing's disease
    • 20463350 10.1056/NEJMc1000094 1:CAS:528:DC%2BC3cXmtVahu7c%3D
    • RA Feelders C de Bruin AM Pereira, et al. 2010 Pasireotide alone or with cabergoline and ketoconazole in Cushing's disease N Engl J Med 362 19 1846 1848 20463350 10.1056/NEJMc1000094 1:CAS:528:DC%2BC3cXmtVahu7c%3D
    • (2010) N Engl J Med , vol.362 , Issue.19 , pp. 1846-1848
    • Feelders, R.A.1    De Bruin, C.2    Pereira, A.M.3
  • 18
    • 84859541722 scopus 로고    scopus 로고
    • The hypercoagulable state in Cushing's disease is associated with increased levels of procoagulant factors and impaired fibrinolysis, but is not reversible after short-term biochemical remission induced by medical therapy
    • 22278425 10.1210/jc.2011-2753
    • R van der Pas C de Bruin FWG Leebeek, et al. 2012 The hypercoagulable state in Cushing's disease is associated with increased levels of procoagulant factors and impaired fibrinolysis, but is not reversible after short-term biochemical remission induced by medical therapy J Clin Endocrinol Metab 97 4 1303 1310 22278425 10.1210/jc.2011-2753
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.4 , pp. 1303-1310
    • Van Der Pas, R.1    De Bruin, C.2    Leebeek, F.W.G.3
  • 19
    • 84859071474 scopus 로고    scopus 로고
    • Effect of hepatic impairment on the pharmacokinetics of pasireotide (SOM230): Results from a multicenter phase i study
    • 22282526 10.1177/0091270011400072 1:CAS:528:DC%2BC38XmsFersLY%3D
    • Y Horsmans K Hu M Ruffin, et al. 2012 Effect of hepatic impairment on the pharmacokinetics of pasireotide (SOM230): results from a multicenter phase I study J Clin Pharmacol 52 4 552 558 22282526 10.1177/0091270011400072 1:CAS:528:DC%2BC38XmsFersLY%3D
    • (2012) J Clin Pharmacol , vol.52 , Issue.4 , pp. 552-558
    • Horsmans, Y.1    Hu, K.2    Ruffin, M.3
  • 20
    • 58149383820 scopus 로고    scopus 로고
    • Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): A multicenter, phase II trial
    • 18957506 10.1210/jc.2008-1008 1:CAS:528:DC%2BD1MXptVKltQ%3D%3D
    • M Boscaro WH Ludlam B Atkinson, et al. 2009 Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial J Clin Endocrinol Metab 94 1 115 122 18957506 10.1210/jc.2008-1008 1:CAS:528: DC%2BD1MXptVKltQ%3D%3D
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.1 , pp. 115-122
    • Boscaro, M.1    Ludlam, W.H.2    Atkinson, B.3
  • 21
    • 85081775647 scopus 로고    scopus 로고
    • Long-term treatment of Cushing's disease with pasireotide (SOM230): Results from a Phase II extension study [abstract no. P640]
    • Prague, 24-28 Apr 2010
    • Boscaro M, Zhang Y, Sen K, et al. Long-term treatment of Cushing's disease with pasireotide (SOM230): results from a Phase II extension study [abstract no. P640]. European Congress of Endocrinology, Prague, 24-28 Apr 2010.
    • European Congress of Endocrinology
    • Boscaro, M.1    Zhang, Y.2    Sen, K.3
  • 22
    • 84857826594 scopus 로고    scopus 로고
    • A 12-month phase 3 study of pasireotide in Cushing's disease
    • 22397653 10.1056/NEJMoa1105743 1:CAS:528:DC%2BC38XktFOgur8%3D
    • A Colao S Petersenn J Newell-Price, et al. 2012 A 12-month phase 3 study of pasireotide in Cushing's disease N Engl J Med 366 10 914 924 22397653 10.1056/NEJMoa1105743 1:CAS:528:DC%2BC38XktFOgur8%3D
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 914-924
    • Colao, A.1    Petersenn, S.2    Newell-Price, J.3
  • 23
    • 84878278263 scopus 로고    scopus 로고
    • Long-term pasireotide use leads to significant and sustained improvements in the signs and symptoms of Cushing disease: 24-month results from a randomized phase III study [abstract]
    • Houston, 23-26 Jun 2012
    • Bertherat J, Schopohl J, Ludlam WH, et al. Long-term pasireotide use leads to significant and sustained improvements in the signs and symptoms of Cushing disease: 24-month results from a randomized phase III study [abstract]. In: 94th Annual Meeting and Expo of the Endocrine Society, Houston, 23-26 Jun 2012.
    • 94th Annual Meeting and Expo of the Endocrine Society
    • Bertherat, J.1    Schopohl, J.2    Ludlam, W.H.3
  • 24
    • 85081780416 scopus 로고    scopus 로고
    • Initial response to pasireotide treatment is predictive of 12-month response: Results of a large, randomized, double-blind, phase III study in patients with Cushing disease [abstract]
    • Houston, 23-26 Jun 2012
    • Lacroix A, Ludlam W, Mantero F, et al. Initial response to pasireotide treatment is predictive of 12-month response: results of a large, randomized, double-blind, phase III study in patients with Cushing disease [abstract]. In: 94th Annual Meeting and Expo of the Endocrine Society, Houston, 23-26 Jun 2012.
    • 94th Annual Meeting and Expo of the Endocrine Society
    • Lacroix, A.1    Ludlam, W.2    Mantero, F.3
  • 25
    • 85081781000 scopus 로고    scopus 로고
    • Long-term pasireotide use leads to improvements in the biochemical parameters of Cushing's disease: 24-month results from a randomized phase III study [abstract no. P1410]
    • Florence, 5-9 May 2012
    • Schopohl J, Bertherat J, Ludlam W, et al. Long-term pasireotide use leads to improvements in the biochemical parameters of Cushing's disease: 24-month results from a randomized phase III study [abstract no. P1410]. In: 15th International Congress of Endocrinology and 14th European Congress of Endocrinology, Florence, 5-9 May 2012.
    • 15th International Congress of Endocrinology and 14th European Congress of Endocrinology
    • Schopohl, J.1    Bertherat, J.2    Ludlam, W.3
  • 26
    • 85081786187 scopus 로고    scopus 로고
    • Pasireotide treatment in Cushing disease is associated with significant improvements in hypertension: 12-month results from a large phase III study [abstract]
    • Houston, 23-26 Jun 2012
    • Pivonello R, Petersenn S, Newell-Price J, et al. Pasireotide treatment in Cushing disease is associated with significant improvements in hypertension: 12-month results from a large phase III study [abstract]. In: 94th Annual Meeting and Expo of the Endocrine Society, Houston, 23-26 Jun 2012.
    • 94th Annual Meeting and Expo of the Endocrine Society
    • Pivonello, R.1    Petersenn, S.2    Newell-Price, J.3
  • 27
    • 85081779115 scopus 로고    scopus 로고
    • Pasireotide treatment is associated with clinically meaningful improvements in health-related quality of life in Cushing disease: Results from a large, randomized, double-blind, phase III trial [abstract]
    • Houston, 23-26 Jun 2012
    • Gadelha M, Badia X, Zgliczynski W, et al. Pasireotide treatment is associated with clinically meaningful improvements in health-related quality of life in Cushing disease: results from a large, randomized, double-blind, phase III trial [abstract]. In: 94th Annual Meeting and Expo of the Endocrine Society, Houston, 23-26 Jun 2012.
    • 94th Annual Meeting and Expo of the Endocrine Society
    • Gadelha, M.1    Badia, X.2    Zgliczynski, W.3
  • 28
    • 85081780368 scopus 로고    scopus 로고
    • Pasireotide as a long-term treatment for patients with Cushing disease: 24-month safety results from a randomized phase III study [abstract]
    • Houston, 23-26 Jun 2012
    • Bertherat J, Ludlam WH, Pivonello R, et al. Pasireotide as a long-term treatment for patients with Cushing disease: 24-month safety results from a randomized phase III study [abstract]. In: 94th Annual Meeting and Expo of the Endocrine Society, Houston, 23-26 Jun 2012.
    • 94th Annual Meeting and Expo of the Endocrine Society
    • Bertherat, J.1    Ludlam, W.H.2    Pivonello, R.3
  • 29
    • 84867399092 scopus 로고    scopus 로고
    • Medical management of Cushing's disease: What is the future?
    • 22674211 10.1007/s11102-012-0397-5 1:CAS:528:DC%2BC38XhtlOlu77J
    • M Fleseriu S Petersenn 2012 Medical management of Cushing's disease: what is the future? Pituitary 15 3 330 341 22674211 10.1007/s11102-012-0397-5 1:CAS:528:DC%2BC38XhtlOlu77J
    • (2012) Pituitary , vol.15 , Issue.3 , pp. 330-341
    • Fleseriu, M.1    Petersenn, S.2
  • 30
    • 85081783040 scopus 로고    scopus 로고
    • Long-term efficacy of pasireotide in a patients with Cushing's disease and diabetes: Results in the short term are not always predictive of long-term response [abstract no. P108]
    • Special 3
    • Trementino L, Cardinaletti M, Concettoni C, et al. Long-term efficacy of pasireotide in a patients with Cushing's disease and diabetes: results in the short term are not always predictive of long-term response [abstract no. P108]. J Clin Endokrinol Stoffw. 2012;5(Special Issue 3).
    • (2012) J Clin Endokrinol Stoffw , vol.5
    • Trementino, L.1    Cardinaletti, M.2    Concettoni, C.3
  • 31
    • 84861691176 scopus 로고    scopus 로고
    • Pasireotide in Cushing's disease [letter]
    • 22646647 10.1056/NEJMc1204078 1:CAS:528:DC%2BC38Xos1eqtLo%3D
    • R Libe L Groussin J Bertherat 2012 Pasireotide in Cushing's disease [letter] N Engl J Med 366 22 2134 22646647 10.1056/NEJMc1204078 1:CAS:528:DC%2BC38Xos1eqtLo%3D
    • (2012) N Engl J Med , vol.366 , Issue.22 , pp. 2134
    • Libe, R.1    Groussin, L.2    Bertherat, J.3
  • 33
    • 84873622229 scopus 로고    scopus 로고
    • Medical treatment of Cushing's disease
    • 23345100 10.1210/jc.2012-3126 1:CAS:528:DC%2BC3sXjtlOlurk%3D
    • RA Feelders LJ Hofland 2013 Medical treatment of Cushing's disease J Clin Endocrinol Metab 98 2 425 438 23345100 10.1210/jc.2012-3126 1:CAS:528:DC%2BC3sXjtlOlurk%3D
    • (2013) J Clin Endocrinol Metab , vol.98 , Issue.2 , pp. 425-438
    • Feelders, R.A.1    Hofland, L.J.2
  • 34
    • 85081777850 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of pasireotide LAR in patients with mild-to-moderate Cushing's disease: A randomized, double-blind, multicentre, phase III study design [abstract no. P1542.1]
    • Florence, 5-9 May 2012
    • Ligueros-Saylan M, Zhang Y, Newell-Price J, et al. Evaluation of the efficacy and safety of pasireotide LAR in patients with mild-to-moderate Cushing's disease: a randomized, double-blind, multicentre, phase III study design [abstract no. P1542.1]. In: 15th International Congress of Endocrinology and 14th European Congress of Endocrinology, Florence, 5-9 May 2012.
    • 15th International Congress of Endocrinology and 14th European Congress of Endocrinology
    • Ligueros-Saylan, M.1    Zhang, Y.2    Newell-Price, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.