The Clinical Characteristics of Two Anti-OJ (Anti-Isoleucyl-tRNA Synthetase) Autoantibody-Positive Interstitial Lung Disease Patients with Polymyositis/Dermatomyositis

Internal Medicine

Volumn 51, Issue 24, 2012, Pages 3405-3410

  Kunimasa, Kei ^a,f   Arita, Machiko ^a   Nakazawa, Takashi ^a   Tanaka, Maki ^a   Tsubouchi, Kazuya ^a,g   Konishi, Satoshi ^a,e   Fukuda, Yasushi ^a   Saigusa, Mika ^a,b   Nakagawa, Hiroaki ^a,c   Ubukata, Satoshi ^a,d   Korogi, Yohei ^a   Fujii, Takao ^e   Mimori, Tsuneyo ^e   Ishida, Tadashi ^a  

^a KURASHIKI CENTRAL HOSPITAL   (Japan)

^b OKAYAMA SAISEIKAI GENERAL HOSPITAL   (Japan)

^c SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^d Saka General Hospital   (Japan)

^e KYOTO UNIVERSITY   (Japan)

^f KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g Division of Pediatrics St Mary's Hospital   (Japan)

Author keywords

Anti aminoacyl tRNA antibodies; Interstitial lung disease; Polymyositis dermatomyositis

Indexed keywords

AUTOANTIBODY; ISOLEUCINE TRANSFER RNA LIGASE;

AGED; ARTICLE; CASE REPORT; DERMATOMYOSITIS; ENZYMOLOGY; FEMALE; HUMAN; IMMUNOLOGY; INTERSTITIAL LUNG DISEASE; MALE; POLYMYOSITIS;

AGED; AUTOANTIBODIES; DERMATOMYOSITIS; FEMALE; HUMANS; ISOLEUCINE-TRNA LIGASE; LUNG DISEASES, INTERSTITIAL; MALE; POLYMYOSITIS;

EID: 84878241055     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.51.7452     Document Type: Article

References (21)

1. Targoff IN. Immune manifestations of inflammatory muscle disease. Rheum Dis Clin North Am 20: 857–880, 1994.
2. Hirakata M, Nagai S. Interstitial lung disease in polymyositis and dermatomyositis. Curr Opin Rheumatol 12: 501–508, 2000.
3. Mathews M, Berstein R. Myositis auto-antibodies inhibits histidyl-tRNA synthetase: A model for auto-immunity. Nature 83: 304–317, 1983.
4. Hirakata M, Suwa A, Nagai S, et al. Anti-KS: Identification of autoantibodies to asparaginyl-transfer RNA synthetase associated with interstitial lung disease. J Immunol 162: 2315–2320, 1999.
5. Betteridge Z, Gunawardena H, North J, Slinn J, McHugh N. Antisynthetase syndrome: A new autoantibody to phenylalanyl transfer RNA synthetase (anti-Zo) associated with polymyositis and interstitial pneumonia. Rheumatology 46: 1005–1008, 2007.
6. Katzap E, Barilla-LaBarca ML, Marder G. Antisynthetase syndrome. Curr Rheumatol Rep 13: 175–181, 2011.
7. Love LA, Leff RL, Fraser DD, et al. A new approach to the classification of idiopathic inflammatory myopathy: Myositis-specific autoantibodies define useful homogeneous patient groups. Medicine 70: 360–374, 1991.
8. Suwa A, Hirakata M, Satoh S, Ezaki T, Mimori T, Inada S. A case of polymyositis with anti-OJ (isoleucyl-transfer RNA synthetase) antibodies. Clin Exp Rheumatol 17: 755–756, 1999.
9. Sato S, Kuwana M, Hirakata M. Clinical characteristics of Japanese patients with anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibodies. Rheumatology 46: 842–845, 2007.
10. Yoshifuji H, Fujii T, Kobayashi S, et al. Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopathic inflammatory myopathies. Autoimmunity 39: 233–241, 2006.
11. Marie I, Hatron PY, Dominique S, et al. Short-term and long-term outcomes of interstitial lung disease in polymyositis and dermatomyositis: A series of 107 patients. Arthritis Rheum 63: 3439–3447, 2011.
12. Marguerie C, Bunn CC, Beynon HL, et al. Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes. Q J Med 77: 1019–1038, 1990.
13. Kang EH, Lee EB, Shin KC, et al. Interstitial lung disease in patients with polymyositis, dermatomyositis and amyopathic dermatomyositis. Rheumatology 44: 1282–1286, 2005.
14. Connors GR, Christopher-Stine L, Oddis CV, Danoff SK. Interstitial lung disease associated with the idiopathic inflammatory myopathies: What progress has been made in the past 35 years? Chest 138: 1464–1474, 2010.
15. Targoff IN. Autoantibodies to aminoacyl-tranfer RNA synthetases for isoleucine and glycine. Two additional synthetases are antigenic in myositis. J Immunol 144: 1737–1743, 1990.
16. Targoff IN, Trieu EP, Miller FW. Reaction of anti-OJ autoantibodies with components of the multi-enzyme complex of aminoacyl-tRNA synthetases in addition to isoleucyl-tRNA synthetase. J Clin Invest 91: 2556–2564, 1993.
17. Koreeda Y, Higashimoto I, Yamamoto M, et al. Clinical and pathological findings of interstitial lung disease patients with antiaminoacyl-tRNA synthetase autoantibodies. Intern Med 49: 361–369, 2010.
18. Shimizu K, Tai H, Kuwano K. A case of cellular NSIP with anti-OJ (anti-isoleucyl tRNA synthetase) antibodies. Nihon Kokyuki Gakkai Zasshi 48: 45–48, 2010.
19. Gelpí C, Kanterewicz E, Gratacos J, Targoff IN, Rodríguez-Sánchez JL. Coexistence of two antisynthetases in a patient with the antisynthetase syndrome. Arthritis Rheum 39: 692–697, 1996.
20. Friedman AW, Targoff IN, Arnett FC. Interstitial lung disease with autoantibodies against aminoacyl-tRNA synthetases in the absence of clinically apparent myositis. Semin Arthritis Rheum 26: 459–467, 1996.
21. Flaherty KR, Toews GB, Travis WD, et al. Clinical significance of histological classification of idiopathic interstitial pneumonia. Eur Respir J 19: 275–283, 2002.