Intracellular protein degradation: From a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 12, 2013, Pages 3400-3410

  Ciechanover, Aaron ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Lysosome; Proteasome; Protein degradation; Ubiquitin

Indexed keywords

CELL PROTEIN; PROTEASOME; TRANSCRIPTION FACTOR; UBIQUITIN;

ARTICLE; CELL CYCLE REGULATION; CELL DIVISION; COMPLEX FORMATION; DEGENERATIVE DISEASE; DRUG TARGETING; HUMAN; LYSOSOME; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; NONHUMAN; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN UNFOLDING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UBIQUITINATION;

EID: 84878231850     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.056     Document Type: Review

References (83)

1. H.T. Clarke Annu. Rev. Biochem. 27 1958 1
2. E.P. Kennedy J. Biol. Chem. 276 2001 42619
3. R.D. Simoni, R.L. Hill, and M. Vaughan J. Biol. Chem. 277 2002 e1 available on-line at: http://www.jbc.org
4. R. Schoenheimer, S. Ratner, and D. Rittenberg J. Biol. Chem. 127 1939 333
5. S. Ratner, D. Rittenberg, A.S. Keston, and R. Schoenheimer J. Biol. Chem. 134 1940 665
6. R.The. Schoenheimer The Dynamic State of Body Constituents 1942 Harvard University Press Cambridge, Massachusetts, USA
7. D.S. Hogness, M. Cohn, and J. Monod Biochim. Biophys. Acta 16 1955 99
8. C. de Duve, R. Gianetto, F. Appelmans, and R. Wattiaux Nature (London) 172 1953 1143
9. R. Gianetto, and C. de Duve Biochem. J. 59 1955 433
10. M.V. Simpson J. Biol. Chem. 201 1953 143
11. G.E. Mortimore, and A.R. Poso Annu. Rev. Nutr. 7 1987 539
12. T.P. Ashford, and K.R. Porter J. Cell Biol. 12 1962 198
13. R.T. Schimke, and D. Doyle Annu. Rev. Biochem. 39 1970 929
14. A.L. Goldberg, and A.C. St. John Annu. Rev. Biochem. 45 1976 747
15. H.L. Segal, J.R. Winkler, and M.P. Miyagi J. Biol. Chem. 249 1974 6364
16. M. Haider, and H.L. Segal Arch. Biochem. Biophys. 148 1972 228
17. R.T. Dean Acta Biol. Med. Ger. 36 1977 1815
18. M. Müller, H. Müller, and H. Holzer J. Biol. Chem. 256 1981 723
19. H. Holzer Rev. Biol. Cell. 21 1989 305
20. A.E. Majeski, and J.F. Dice Int. J. Biochem. Cell Biol. 36 2004 2435
21. A.M. Cuervo, and J.F. Dice J. Mol. Med. 76 1998 6
22. M. Hayashi, Y. Hiroi, and Y. Natori Nat. New Biol. 242 1973 163
23. D.L. Schneider J. Biol. Chem. 256 1981 3858
24. C. de Duve, and R. Wattiaux Annu. Rev. Physiol. 28 1966 435
25. M. Rabinovitz, and J.M. Fisher Biochim. Biophys. Acta 91 1964 313
26. R.W. Carrell, and H. Lehmann Semin. Hematol. 6 1969 116
27. E.R. Huehns, and A.J. Bellingham Br. J. Haematol. 17 1969 1
28. J.D. Etlinger, and A.L. Goldberg Proc. Natl. Acad. Sci. U.S.A. 74 1977 54
29. A. Hershko, H. Heller, D. Ganoth, and A. Ciechanover Mode of Degradation of Abnormal Globin Chains in Rabbit Reticulocytes H.L. Segal, D.J. Doyle, Protein Turnover and Lysosome Function 1978 Academic Press New York 149 169
30. S.E. Knowles, and F.J. Ballard Biochem. J. 156 1976 609
31. N.T. Neff, G.N. DeMartino, and A.L. Goldberg J. Cell Physiol. 101 1979 439
32. B. Poole, S. Ohkuma, and M.J. Warburton Acta Biol. Med. Ger. 36 1977 1777
33. B. Poole, S. Ohkuma, and M.J. Warburton Some Aspects of the Intracellular Breakdown of Exogenous and Endogenous Proteins H.L. Segal, D.J. Doyle, Protein Turnover and Lysosome Function 1978 Academic Press New York 43 58
34. J. Mandelstam Biochem. J. 69 1958 110
35. D. Steinberg, and M. Vaughan Arch. Biochem. Biophys. 65 1956 93
36. A. Hershko, and G.M. Tomkins J. Biol. Chem. 246 1971 710
37. A.L. Goldberg, J.D. Kowit, and J.D. Etlinger Studies on the Selectivity and Mechanisms of Intracellular Protein Degradation D.W. Ribbons, K. Brew, Proteolysis and Physiological Regulation 1976 Academic Press New York 313 337
38. A. Ciechanover, Y. Hod, and A. Hershko Biochem. Biophys. Res. Commun. 81 1978 1100
39. A. Ciechanover, H. Heller, S. Elias, A.L. Haas, and A. Hershko Proc. Natl. Acad. Sci. U.S.A. 77 1980 1365
40. A. Hershko, A. Ciechanover, H. Heller, A.L. Haas, and I.A. Rose Proc. Natl. Acad. Sci. U.S.A. 77 1980 1783
41. A. Ciechanover, S. Elias, H. Heller, S. Ferber, and A. Hershko J. Biol. Chem. 255 1980 7525
42. K.D. Wilkinson, M.K. Urban, and A.L. Haas J. Biol. Chem. 255 1980 7529
43. G. Goldstein Nature (London) 247 1974 11
44. G. Goldstein, M. Scheid, U. Hammerling, D.H. Schlesinger, H.D. Niall, and E.A. Boyse Proc. Natl. Acad. Sci. U.S.A. 72 1975 11
45. D.H. Schlessinger, G. Goldstein, and H.D. Niall Biochemistry 14 1975 2214
46. T.L.K. Low, and A.L. Goldstein J. Biol. Chem. 254 1979 987
47. I.L. Goldknopf, and H. Busch Biochem. Biophys. Res. Commun. 65 1975 951
48. I.L. Goldknopf, and H. Busch Proc. Natl. Acad. Sci. U.S.A. 74 1977 864
49. L.T. Hunt, and M.O. Dayhoff Biochim. Biophys. Res. Commun. 74 1977 650
50. A. Hershko, A. Ciechanover, and I.A. Rose J. Biol. Chem. 256 1981 1525
51. A. Hershko, and H. Heller Biochem. Biophys. Res. Commun. 128 1985 1079
52. V. Chau, J.W. Tobias, A. Bachmair, D. Mariott, D. Ecker, D.K. Gonda, and A. Varshavsky Science 243 1989 1576
53. A. Ciechanover, and R. Ben-Saadon Trends Cell Biol. 14 2004 103
54. M. Muratani, and W.P. Tansey How the ubiquitin-proteasome system controls transcription Nat. Rev. Mol. Cell Biol. 4 2003 192
55. Y. Zhang Genes Dev. 17 2003 2733
56. M.A. Osley Biochim. Biophys. Acta 1677 2004 74
57. F. Lipman Science 173 1971 875
58. A. Ciechanover, S. Elias, H. Heller, and A. Hershko J. Biol. Chem. 257 1982 2537
59. A. Hershko, H. Heller, S. Elias, and A. Ciechanover J. Biol. Chem. 258 1983 8206
60. D.T. Chin, L. Kuehl, and M. Rechsteiner Proc. Natl. Acad. Sci. U.S.A. 79 1982 5857
61. A. Hershko, E. Eytan, A. Ciechanover, and A.L. Haas J. Biol. Chem. 257 1982 13964
62. Y. Matsumoto, H. Yasuda, T. Marunouchi, and M. Yamada FEBS Lett. 151 1983 139
63. D. Finley, A. Ciechanover, and A. Varshavsky Cell 37 1984 43
64. A. Ciechanover, D. Finley, and A. Varshavsky Cell 37 1984 57
65. K. Tanaka, L. Waxman, and A.L. Goldberg J. Cell Biol. 96 1983 1580
66. A. Hershko, E. Leshinsky, D. Ganoth, and H. Heller Proc. Natl. Acad. Sci. U.S.A. 81 1984 1619
67. R. Hough, G. Pratt, and M. Rechsteiner J. Biol. Chem. 261 1986 2400
68. L. Waxman, J. Fagan, and A.L. Goldberg J. Biol. Chem. 262 1987 2451
69. R. Hough, G. Pratt, and M. Rechsteiner J. Biol. Chem. 262 1987 8303
70. S. Wilk, and M. Orlowski J. Neurochem. 35 1980 1172
71. E. Eytan, D. Ganoth, T. Armon, and A. Hershko Proc. Natl. Acad. Sci. U.S.A. 86 1989 7751
72. J. Driscoll, and A.L. Goldberg J. Biol. Chem. 265 1990 4789
73. L. Hoffman, G. Pratt, and M. Rechsteiner J. Biol. Chem. 267 1992 22362
74. J. Shanklin, M. Jaben, and R.D. Vierstra Proc. Natl. Acad. Sci. U.S.A. 84 1987 359
75. M. Hochstrasser, and A. Varshavsky Cell 61 1990 697
76. M. Scheffner, B.A. Werness, J.M. Huibregtse, A.J. Levine, and P.M. Howley Cell 63 1990 1129
77. M. Glotzer, A.W. Murray, and M.W. Kirschner Nature 349 1991 132
78. A. Ciechanover, J.A. DiGiuseppe, B. Bercovich, A. Orian, J.D. Richter, A.L. Schwartz, and G.M. Brodeur Proc. Natl. Acad. Sci. U.S.A. 88 1991 139
79. N. Mizushima, T. Noda, T. Yoshimori, Y. Tanaka, T. Ishii, M.D. George, D.J. Klionsky, M. Ohsumi, and Y. Ohsumi Nature 395 1998 395
80. J. Adams Drug Discovery Today 8 2003 307
81. M.H. Glickman, and A. Ciechanover Physiol. Rev. 82 2002 373
82. C.M. Pickart, and R.E. Cohen Nat. Rev. Mol. Cell Biol. 5 2004 177
83. A. Ciechanover Nat. Rev. Mol. Cell Biol. 6 2005 79