-
1
-
-
33846424247
-
The Failure of Torcetrapib: Was it the molecule or the mechanism?
-
Tall AR, Yvan-Charvet L, Wang N. The Failure of Torcetrapib: Was it the molecule or the mechanism?. Arteriosclerosis, Thrombosis, Vasc Biol 2007, 27:257-260.
-
(2007)
Arteriosclerosis, Thrombosis, Vasc Biol
, vol.27
, pp. 257-260
-
-
Tall, A.R.1
Yvan-Charvet, L.2
Wang, N.3
-
2
-
-
48149083115
-
The failure of torcetrapib: what have we learned?
-
Joy TR, Hegele RA. The failure of torcetrapib: what have we learned?. British J Pharmacol 2008, 154:1379-1381.
-
(2008)
British J Pharmacol
, vol.154
, pp. 1379-1381
-
-
Joy, T.R.1
Hegele, R.A.2
-
3
-
-
67349279795
-
A Translational Medicine perspective of the development of torcetrapib: Does the failure of torcetrapib development cast a shadow on future development of lipid modifying agents, HDL elevation strategies or CETP as a viable molecular target for atherosclerosis? A case study of the use of biomarkers and Translational Medicine in atherosclerosis drug discovery and development
-
Zhao L, Jin W, Rader D, Packard C, Feuerstein G. A Translational Medicine perspective of the development of torcetrapib: Does the failure of torcetrapib development cast a shadow on future development of lipid modifying agents, HDL elevation strategies or CETP as a viable molecular target for atherosclerosis? A case study of the use of biomarkers and Translational Medicine in atherosclerosis drug discovery and development. Biochem Pharmacol 2009, 78:315-325.
-
(2009)
Biochem Pharmacol
, vol.78
, pp. 315-325
-
-
Zhao, L.1
Jin, W.2
Rader, D.3
Packard, C.4
Feuerstein, G.5
-
4
-
-
80053999955
-
Phase II failures: 2008-2010
-
Arrowsmith J. Phase II failures: 2008-2010. Nat Rev Drug Discov 2011, 10:1.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 1
-
-
Arrowsmith, J.1
-
5
-
-
84860690620
-
Can the flow of medicines be improved? Fundamental pharamacokinetic and pharmacological principles toward improving Phase II survival
-
Morgan P, Graaf PHVD, Arrowsmith J, Feltner DE, Drummond KS, Wegner CD, Street SDA. Can the flow of medicines be improved? Fundamental pharamacokinetic and pharmacological principles toward improving Phase II survival. Drug Discov Today 2012, 17:419-424.
-
(2012)
Drug Discov Today
, vol.17
, pp. 419-424
-
-
Morgan, P.1
Graaf, P.H.V.D.2
Arrowsmith, J.3
Feltner, D.E.4
Drummond, K.S.5
Wegner, C.D.6
Street, S.D.A.7
-
6
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates?. Nat Rev Drug Discov 2004, 3:711-715.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
7
-
-
80053999955
-
Phase III and submission failures: 2007-2010
-
Arrowsmith J. Phase III and submission failures: 2007-2010. Nat Rev Drug Discov 2011, 10:1.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 1
-
-
Arrowsmith, J.1
-
8
-
-
57749107808
-
Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America
-
Rice LB
-
Boucher HW, Talbot GH, Bradley J, JEE G, Bartlett J, Rice LB Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America. Clin Infect Dis 2009, 48:1-12. Rice LB.
-
(2009)
Clin Infect Dis
, vol.48
, pp. 1-12
-
-
Boucher, H.W.1
Talbot, G.H.2
Bradley, J.3
Jee, G.4
Bartlett, J.5
-
9
-
-
77949673913
-
The design of phase II clinical trials testing cancer therapeutics: consensus recommendations from the clinical trial design task force of the National Cancer Institute Investigational Drug Steering Committee
-
Seymour L, Ivy SP, Sargent D, Spriggs D, Baker L, Rubinstein L, Ratain MJ, Blanc ML, Stewart D, Crowley J, Groshen S, Humphrey JS, West P, Berry D. The design of phase II clinical trials testing cancer therapeutics: consensus recommendations from the clinical trial design task force of the National Cancer Institute Investigational Drug Steering Committee. Clin Cancer Res 2010, 16:1764-1769.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1764-1769
-
-
Seymour, L.1
Ivy, S.P.2
Sargent, D.3
Spriggs, D.4
Baker, L.5
Rubinstein, L.6
Ratain, M.J.7
Blanc, M.L.8
Stewart, D.9
Crowley, J.10
Groshen, S.11
Humphrey, J.S.12
West, P.13
Berry, D.14
-
10
-
-
84878663091
-
The global plan to stop TB
-
StopTBPartnership
-
StopTBPartnership The global plan to stop TB. World Health Organization 2010 [http://www.stoptb.org/assets/documents/global/plan/TB_GlobalPlanToStopTB2011-2015.pdf], StopTBPartnership.
-
World Health Organization 2010
-
-
-
12
-
-
84866498666
-
A theoretical framework for early human studies: Uncertainty, intervention ensembles, and boundaries
-
Kimmelman J. A theoretical framework for early human studies: Uncertainty, intervention ensembles, and boundaries. Trials 2012, 13:173.
-
(2012)
Trials
, vol.13
, pp. 173
-
-
Kimmelman, J.1
-
13
-
-
80055088241
-
Believe it or not: how much can we rely on published data on potential drug targets?
-
Prinz F, Schlange T, Asadullah K. Believe it or not: how much can we rely on published data on potential drug targets?. Nat Rev Drug Discov 2011, 10:712-713.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 712-713
-
-
Prinz, F.1
Schlange, T.2
Asadullah, K.3
-
14
-
-
84859169880
-
Raise standards for preclinical cancer research
-
Begley CG, Ellis LM. Raise standards for preclinical cancer research. Nature 2012, 483:531-533.
-
(2012)
Nature
, vol.483
, pp. 531-533
-
-
Begley, C.G.1
Ellis, L.M.2
-
15
-
-
0031879709
-
In Vitro and In Vivo activities of Moxifloxacin and Clinafloxacin against mycobacterium tuberculosis
-
Ji B, Lounis N, Maslo C, Truffot-Pernot C, Bonnafous P, Grosset J. In Vitro and In Vivo activities of Moxifloxacin and Clinafloxacin against mycobacterium tuberculosis. Antimicrob Agents Chemother 1998, 42:2066-2069.
-
(1998)
Antimicrob Agents Chemother
, vol.42
, pp. 2066-2069
-
-
Ji, B.1
Lounis, N.2
Maslo, C.3
Truffot-Pernot, C.4
Bonnafous, P.5
Grosset, J.6
-
16
-
-
0032870624
-
Activity of Moxifloxacin against Mycobacteria
-
Gillespie S, Billington O. Activity of Moxifloxacin against Mycobacteria. J Antimicrob Chemother 1999, 44:393-395.
-
(1999)
J Antimicrob Chemother
, vol.44
, pp. 393-395
-
-
Gillespie, S.1
Billington, O.2
-
17
-
-
33846612373
-
Moxifloxacin, Ofloxacin, Sparfloxacin, and Ciprofloxacin against Mycobacterium tuberculosis: evaluation of In Vitro and Pharmacodynamic indices that best predict In Vivo efficacy
-
Shandil RK, Jayaram R, Kaur P, Gaonkar S, Suresh BL, Mahesh BN, Jayashree R, Nandi V, Bharath S, Balasubramanian V. Moxifloxacin, Ofloxacin, Sparfloxacin, and Ciprofloxacin against Mycobacterium tuberculosis: evaluation of In Vitro and Pharmacodynamic indices that best predict In Vivo efficacy. Antimicrob Agents Chemother 2007, 51:576-582.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 576-582
-
-
Shandil, R.K.1
Jayaram, R.2
Kaur, P.3
Gaonkar, S.4
Suresh, B.L.5
Mahesh, B.N.6
Jayashree, R.7
Nandi, V.8
Bharath, S.9
Balasubramanian, V.10
-
18
-
-
0032910406
-
Moxifloxacin (BAY12-8039), a new 8-methoxyquinolone, is active in a mouse model of tuberculosis
-
Miyazaki E, Miyazaki M, Chen J, Chaisson R, Bishai W. Moxifloxacin (BAY12-8039), a new 8-methoxyquinolone, is active in a mouse model of tuberculosis. Antimicrob Agents Chemother 1999, 43:85-89.
-
(1999)
Antimicrob Agents Chemother
, vol.43
, pp. 85-89
-
-
Miyazaki, E.1
Miyazaki, M.2
Chen, J.3
Chaisson, R.4
Bishai, W.5
-
19
-
-
0035191458
-
Effectiveness of once-weekly Rifapentine and Moxifloxacin regimens against Mycobacterium tuberculosis in mice
-
Lounis N, Bentoucha A, Truffot-Pernot C, Ji B, O'Brien R, Vernon A, Roscigno G, Grosset J. Effectiveness of once-weekly Rifapentine and Moxifloxacin regimens against Mycobacterium tuberculosis in mice. Antimicrob Agents Chemother 2001, 45:3482-3486.
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 3482-3486
-
-
Lounis, N.1
Bentoucha, A.2
Truffot-Pernot, C.3
Ji, B.4
O'Brien, R.5
Vernon, A.6
Roscigno, G.7
Grosset, J.8
-
20
-
-
0036090655
-
Bactericidal activity of increasing daily and weekly doses of Moxifloxacin in Murine tuberculosis
-
Yoshimatsu T, Nuermberger E, Tyagi S, Chaisson R, Bishai W, Grosset J. Bactericidal activity of increasing daily and weekly doses of Moxifloxacin in Murine tuberculosis. Antimicrob Agents Chemother 2002, 46:1875-1879.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 1875-1879
-
-
Yoshimatsu, T.1
Nuermberger, E.2
Tyagi, S.3
Chaisson, R.4
Bishai, W.5
Grosset, J.6
-
21
-
-
1642537638
-
Moxifloxacin-containing regimen greatly reduces time to culture conversion in Murine tuberculosis
-
Nuermberger E, Yoshimatsu T, Tyagi S, O'Brien R, Vernon A, Chaisson R, Bishai W, Grosset J. Moxifloxacin-containing regimen greatly reduces time to culture conversion in Murine tuberculosis. Am J Respir Crit Care Med 2004, 169:421-426.
-
(2004)
Am J Respir Crit Care Med
, vol.169
, pp. 421-426
-
-
Nuermberger, E.1
Yoshimatsu, T.2
Tyagi, S.3
O'Brien, R.4
Vernon, A.5
Chaisson, R.6
Bishai, W.7
Grosset, J.8
-
22
-
-
0344742227
-
The bactericidal activity of Moxifloxacin in patients with pulmonary tuberculosis
-
Gosling R, Uiso L, Sam N, Bongard E, Kanduma E, Nyindo M, Morris R, Gillespie S. The bactericidal activity of Moxifloxacin in patients with pulmonary tuberculosis. Am J Respir Crit Care Med 2003, 168:1342-1345.
-
(2003)
Am J Respir Crit Care Med
, vol.168
, pp. 1342-1345
-
-
Gosling, R.1
Uiso, L.2
Sam, N.3
Bongard, E.4
Kanduma, E.5
Nyindo, M.6
Morris, R.7
Gillespie, S.8
-
23
-
-
1442275724
-
Early bactericidal activity of Moxifloxacin in treatment of pulmonary tuberculosis: a prospective, randomized study
-
Pletz M, Roux AD, Roth A, Neumann K, Mauch H, Lode H. Early bactericidal activity of Moxifloxacin in treatment of pulmonary tuberculosis: a prospective, randomized study. Antimicrob Agents Chemother 2004, 48:780-782.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 780-782
-
-
Pletz, M.1
Roux, A.D.2
Roth, A.3
Neumann, K.4
Mauch, H.5
Lode, H.6
-
24
-
-
29444453676
-
Early bactericidal activity of a Moxifloxacin and Isoniazid combination in smear-positive pulmonary tuberculosis
-
Gillespie S, Gosling R, Uiso L, Sam N, Kanduma E, McHugh T. Early bactericidal activity of a Moxifloxacin and Isoniazid combination in smear-positive pulmonary tuberculosis. J Antimicrob Chemother 2005, 56:1169-1171.
-
(2005)
J Antimicrob Chemother
, vol.56
, pp. 1169-1171
-
-
Gillespie, S.1
Gosling, R.2
Uiso, L.3
Sam, N.4
Kanduma, E.5
McHugh, T.6
-
25
-
-
33744924880
-
Maciel E, et al.: Early and extended early bactericidal activity of Levofloxacin, Gatifloxacin and Moxifloxacin in pulmonary tuberculosis
-
Johnson J, Hadad D, Boom W, Daley C, Peloquin C, Eisenach K, Jankus D, Debanne S, Charlebois E, et al. Maciel E, et al.: Early and extended early bactericidal activity of Levofloxacin, Gatifloxacin and Moxifloxacin in pulmonary tuberculosis. Int J Tuberc Lung Dis 2006, 10:605-612.
-
(2006)
Int J Tuberc Lung Dis
, vol.10
, pp. 605-612
-
-
Johnson, J.1
Hadad, D.2
Boom, W.3
Daley, C.4
Peloquin, C.5
Eisenach, K.6
Jankus, D.7
Debanne, S.8
Charlebois, E.9
-
26
-
-
34848837607
-
Rifampicin reduces plasma concentrations of Moxifloxacin in patients with tuberculosis
-
Nijland HMJ, Ruslami R, Suroto AJ, Burger DM, Alisjahbana B, van C, Aarnoutse RE. Rifampicin reduces plasma concentrations of Moxifloxacin in patients with tuberculosis. Clin Infect Dis 2007, 45:1001-1007.
-
(2007)
Clin Infect Dis
, vol.45
, pp. 1001-1007
-
-
Nijland, H.M.J.1
Ruslami, R.2
Suroto, A.J.3
Burger, D.M.4
Alisjahbana, B.5
van, C.6
Aarnoutse, R.E.7
-
27
-
-
40549084636
-
Population Pharmacokinetics of Levofloxacin, Gatifloxacin, and Moxifloxacin in adults with pulmonary tuberculosis
-
Peloquin CA, Hadad DJ, Molino LPD, Palaci M, Boom WH, Dietze R, Johnson JL. Population Pharmacokinetics of Levofloxacin, Gatifloxacin, and Moxifloxacin in adults with pulmonary tuberculosis. Antimicrob Agents Chemother 2008, 52:852-857.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 852-857
-
-
Peloquin, C.A.1
Hadad, D.J.2
Molino, L.P.D.3
Palaci, M.4
Boom, W.H.5
Dietze, R.6
Johnson, J.L.7
-
28
-
-
33746599368
-
Zhao Z, et al.: Moxifloxacin versus Ethambutol in the first 2 months of treatment for pulmonary tuberculosis
-
Burman W, Goldberg S, Muzanye JJG, Engle M, Mosher A, Choudhri S, Daley C, Munsiff S, et al. Zhao Z, et al.: Moxifloxacin versus Ethambutol in the first 2 months of treatment for pulmonary tuberculosis. Am J Respir Crit Care Med 2006, 174:331-338.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 331-338
-
-
Burman, W.1
Goldberg, S.2
Muzanye, J.J.G.3
Engle, M.4
Mosher, A.5
Choudhri, S.6
Daley, C.7
Munsiff, S.8
-
29
-
-
38949197081
-
A phase II study of the sterilising activities of Ofloxacin, Gatifloxacin and Moxifloxacin in pulmonary tuberculosis
-
for TB (OFLOTUB) study team G.
-
Rustomjee R, Lienhardt C, Kanyok T, for TB (OFLOTUB) study team G. A phase II study of the sterilising activities of Ofloxacin, Gatifloxacin and Moxifloxacin in pulmonary tuberculosis. Int J Tuberc Lung Dis 2008, 12:128-138.
-
(2008)
Int J Tuberc Lung Dis
, vol.12
, pp. 128-138
-
-
Rustomjee, R.1
Lienhardt, C.2
Kanyok, T.3
-
30
-
-
67749120902
-
Moxifloxacin versus Ethambutol in the initial treatment of tuberculosis: a double-blind, randomised, controlled phase II trial
-
Conde M, Efron A, Loredo C, Souza GD, Gracxa N, Cezar M, Ram M, Chaudhary M, Bishai W, Kritski A, Chaisson R. Moxifloxacin versus Ethambutol in the initial treatment of tuberculosis: a double-blind, randomised, controlled phase II trial. Lancet 2009, 53:1314-1319.
-
(2009)
Lancet
, vol.53
, pp. 1314-1319
-
-
Conde, M.1
Efron, A.2
Loredo, C.3
Souza, G.D.4
Gracxa, N.5
Cezar, M.6
Ram, M.7
Chaudhary, M.8
Bishai, W.9
Kritski, A.10
Chaisson, R.11
-
31
-
-
67749086328
-
Goldberg S, et al.: Substitution of Moxifloxacin for Isoniazid during intensive phase treatment of pulmonary tuberculosis
-
Dorman S, Johnson J, et al. Goldberg S, et al.: Substitution of Moxifloxacin for Isoniazid during intensive phase treatment of pulmonary tuberculosis. Am J Respir Crit Care Med 2009, 180:273-280.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 273-280
-
-
Dorman, S.1
Johnson, J.2
-
32
-
-
76149124232
-
Adding Moxifloxacin is associated with a shorter time to culture conversion in pulmonary tuberculosis
-
Wang JY, Wang JT, Tsai T, Hsu C, Yu C, Hsueh P, Lee L, Yang P. Adding Moxifloxacin is associated with a shorter time to culture conversion in pulmonary tuberculosis. Int J Tuberc Lung Dis 2009, 14:65-71.
-
(2009)
Int J Tuberc Lung Dis
, vol.14
, pp. 65-71
-
-
Wang, J.Y.1
Wang, J.T.2
Tsai, T.3
Hsu, C.4
Yu, C.5
Hsueh, P.6
Lee, L.7
Yang, P.8
-
33
-
-
63449090101
-
A pragmatic-explanatory continuum indicator summary (PRECIS): a tool to help trial designers
-
Thorpe KE, Zwarenstein M, Oxman AD, Treweek S, Furberg CD, Altman DG, Tunis S, Bergel E, Harvey I, Magid DJ, Chalkidou K. A pragmatic-explanatory continuum indicator summary (PRECIS): a tool to help trial designers. J Clin Epidemiol 2009, 62:464-475.
-
(2009)
J Clin Epidemiol
, vol.62
, pp. 464-475
-
-
Thorpe, K.E.1
Zwarenstein, M.2
Oxman, A.D.3
Treweek, S.4
Furberg, C.D.5
Altman, D.G.6
Tunis, S.7
Bergel, E.8
Harvey, I.9
Magid, D.J.10
Chalkidou, K.11
-
34
-
-
84861137587
-
Graphical augmentations to the funnel plot assess the impact of additional evidence on a meta-analysis
-
Langan D, Higgins JPT, Gregory W, Sutton AJ. Graphical augmentations to the funnel plot assess the impact of additional evidence on a meta-analysis. J Clin Epidemiol 2012, 65:511-519.
-
(2012)
J Clin Epidemiol
, vol.65
, pp. 511-519
-
-
Langan, D.1
Higgins, J.P.T.2
Gregory, W.3
Sutton, A.J.4
|