Sporicidal efficacy of pH-adjusted bleach for control of bioburden on production facility surfaces

Journal of Industrial Microbiology and Biotechnology

Volumn 40, Issue 6, 2013, Pages 601-611

  Frazer, Anne Cornish ^a,b   Smyth, Josephine N ^a   Bhupathiraju, Vishvesh K ^a,c  

^a BAYER CORPORATION   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Biologics Development Center Survey   (India)

Author keywords

Bleach; Cleanrooms; Disinfection; Hypochlorous acid; pH adjustment; Sporicide

Indexed keywords

ACETIC ACID; CHLORATE; CHLORINE; HYPOCHLORITE SODIUM;

ARTICLE; BACILLUS MEGATERIUM; BACILLUS PUMILUS; BACTERIAL SPORE; BACTERICIDAL ACTIVITY; BLEACHING; COLONY FORMING UNIT; DEGRADATION; DISINFECTION; DRUG INDUSTRY; NONHUMAN; PH; SURFACE PROPERTY;

ACETIC ACID; COLONY COUNT, MICROBIAL; DISINFECTANTS; DISINFECTION; DRUG STABILITY; HYDROCHLORIC ACID; HYDROGEN-ION CONCENTRATION; HYPOCHLOROUS ACID; SODIUM HYPOCHLORITE; SPORES, BACTERIAL; SURFACE PROPERTIES; TIME FACTORS;

BACILLUS ANTHRACIS; BACILLUS PUMILUS;

EID: 84878215483     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-013-1257-7     Document Type: Article

References (24)

1. Adam LC, Fabian I, Suzuki K, Gordon G (1992) Hypochlorous acid decomposition in the pH 5-8 region. Inorg Chem 31:3534-3541
2. Albrich JM, McCarthy CA, Hurst JK (1981) Biological reactivity of hypochlorous acid: implications for microbicidal mechanisms of leukocyte myeloperoxidase. Proc Natl Acad Sci USA 78:210-214
3. Black and Veatch Corporation (2010) White's handbook of chlorination and alternative disinfectants, 5th edn. Wiley, Hoboken
4. Brazis AR, Leslie JE, Kabler PW, Woodward RL (1958) The inactivation of spores of Bacillus globigii and Bacillus anthracis by free available chlorine. Appl Microbiol 6:338-342
5. CEN (European Committee for Standardization) (2001) EN 13697 chemical disinfectants and antiseptics - quantitative non-porous surface test for the evaluation of bactericidal and/or fungicidal activity of chemical disinfectants used in food, industrial, domestic and institutional areas - test method and requirements without mechanical action (phase 2/step 2). CEN, Brussels
6. Dychdala GR (2001) Chlorine and chlorine compounds. In: Block SS (ed) Disinfection, sterilization, and preservation, 5th edn. Lippincott, Williams and Wilkins, New York, pp 135-157
7. Fukuzaki S (2006) Mechanisms of actions of sodium hypochlorite in cleaning and disinfection processes. Biocontrol Sci 11:147-157
8. Hawkins CL, Pattison DI, Davies MJ (2003) Hypochlorite-induced oxidation of amino acids, peptides and proteins. Amino Acids 25:259-274
9. Hussain A, Trudell P, Repta AJ (1970) Quantitative spectrophotometric methods for determination of sodium hypochlorite in aqueous solutions. J Pharm Sci 59:1168-1170
10. Kaatz GW, Gitlin SG, Schaberg DR, Wilson KH, Kauffman CA, Seo SM, Fekety R (1988) Acquisition of Clostridium difficile from the hospital environment. Am J Epidemiol 127:1289-1294
11. Kuroiwa K, Nakayama H, Kuwahara T, Tamagawa K, Hattori K, Murakami K, Korai H, Ohnishi Y (2003) Augmenting effect of acetic acid for acidification on bactericidal activity of hypochlorite solution. Lett Appl Microbiol 36:46-49
12. Levine M (1952) Spores as reagents for studies on chemical disinfection. Bacteriol Rev 16:117-125
13. Morris JC (1966) The acid ionization constant of HOCl from 5 to 35 C. J Phys Chem 70:3798-3805
14. Official Methods of Analysis (1990) AOAC method 966.04: sporicidal activity of disinfectants, 15th edn. AOAC International, Gaithersburg
15. Park GW, Boston DM, Kase JA, Sampson MN, Sobsey MD (2007) Evaluation of liquid- and fog-based application of Sterilox hypochlorous acid solution for surface inactivation of human norovirus. Appl Environ Microbiol 73:4463-4468
16. Prince AM, Andrus L (1992) PCR: how to kill unwanted DNA. Biotechniques 12:358-360
17. Priscott PK, Dai Y (2008) Disinfectants program. In: Prince R (ed) Microbiology in pharmaceutical manufacturing, 2nd edn. PDA/DHI, Bethesda, pp 93-114
18. Rose LJ, Rice EW, Jensen B, Murga R, Peterson A, Donlan RM, Arduino MJ (2005) Chlorine inactivation of bacterial bioterrorism agents. Appl Environ Microbiol 71:566-568
19. Sagripanti J-L, Bonifacino A (1996) Comparative sporicidal effects of liquid chemical agents. Appl Environ Microbiol 62:545-551
20. Tomasino SF, Hamilton MA (2007) Comparative evaluation of two quantitative test methods for determining the efficacy of liquid sporicides and sterilants on a hard surface: a precollaborative study. J AOAC Int 90:456-464
21. US Pharmacopeia 32 rev. and the National Formulary 27th edn (2008) General chapter 1072: disinfectants and antiseptics. US Pharmacopoeial Convention, Rockville
22. USEPA (2012) Anthrax spore decontamination using bleach (sodium hypochlorite). http://www.epa.gov/pesticides/factsheets/chemicals/ bleachfactsheet.htm. Accessed 27 Nov 2012
23. Whitney EAS, Beatty ME, Taylor TH Jr, Weyant R, Sobel J, Arduino MJ, Ashford DA (2003) Inactivation of Bacillus anthracis spores. Emerg Infect Dis 9:623-627
24. Winter J, Ilbert M, Graf PCF, Ozcelik D, Jakob U (2008) Bleach activates a redox-regulated chaperone by oxidative protein unfolding. Cell 135:691-701