A mathematical model of natural killer cell activity

Cytometry Part A

Volumn 83 A, Issue 6, 2013, Pages 585-591

  Scherbakova, Anna ^a,b   Lust, Helen ^a,b   Everaus, Hele ^a,b,c   Aints, Alar ^a,b,c  

^a UNIVERSITY OF TARTU   (Estonia)

^b Department of Immunotherapy   (Estonia)

^c TARTU UNIVERSITY HOSPITAL   (Estonia)

Author keywords

Cytometry; Cytotoxicity; Mathematical model; Natural killer cells

Indexed keywords

HLA ANTIGEN;

ARTICLE; COCULTURE; CYTOLOGY; CYTOTOXICITY; FLOW CYTOMETRY; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; NATURAL KILLER CELL; STATISTICAL MODEL; TUMOR CELL LINE;

CELL LINE, TUMOR; COCULTURE TECHNIQUES; CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; GENE EXPRESSION; HLA ANTIGENS; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MODELS, STATISTICAL;

EID: 84878196015     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.22283     Document Type: Article

References (13)

1. Trinchieri G. Biology of natural killer cells. Adv Immunol 1989; 47: 187-376.
2. Huntington ND, Vosshenrich CAJ, Di Santo JP. Developmental pathways that generate natural-killer-cell diversity in mice and humans. Nat Rev Immunol 2007; 7: 703-714.
3. Parham P, McQueen KL. Alloreactive killer cells: Hindrance and help for haematopoietic transplants. Nat Rev Immunol 2003; 3: 108-122.
4. Ruggeri L, Aversa F, Martelli MF, Velardi A. Allogeneic hematopoietic transplantation and natural killer cell recognition of missing self. Immunol Rev 2006; 214: 202-218.
5. Velardi A. Role of KIRs and KIR ligands in hematopoietic transplantation. Curr Opin Immunol 2008; 20: 581-587.
6. Hallett WHD, Murphy WJ. Natural killer cells: Biology and clinical use in cancer therapy. Cell Mol Immunol 2004; 1: 12-21.
7. Lecoeur H, Février M, Garcia S, Rivière Y, Gougeon ML. A novel flow cytometric assay for quantitation and multiparametric characterization of cell-mediated cytotoxicity. J Immunol Methods 2001; 253: 177-187.
8. Miller JS, Soignier Y, Panoskaltsis-Mortari A, McNearney SA, Yun GH, Fautsch SK, et al. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood 2005; 105: 3051-3057.
9. Carlens S, Gilljam M, Chambers BJ, Aschan J, Guven H, Ljunggren HG, Christensson B, Dilber MS. A new method for in vitro expansion of cytotoxic human CD3-CD56+ natural killer cells. Hum Immunol 2001; 62: 1092-1098.
10. Rosenberg SA, Dudley ME. Adoptive cell therapy for the treatment of patients with metastatic melanoma. Curr Opin Immunol 2009; 21: 233-240.
11. Savary CA, Lotzová E, Gray KN, Jardine JH. Natural killer cell-mediated antitumor reactivity of rhesus monkeys. Nat Immun Cell Growth Regul 1985; 4: 328-339.
12. Cao L-F, Krymskaya L, Tran V, Mi S, Jensen MC, Blanchard S, Kalos M. Development and application of a multiplexable flow cytometry-based assay to quantify cell-mediated cytolysis. Cytometry A 2010; 77A: 534-545.
13. Langhans B, Ahrendt M, Nattermann J, Sauerbruch T, Spengler U. Comparative study of NK cell-mediated cytotoxicity using radioactive and flow cytometric cytotoxicity assays. J Immunol Methods 2005; 306: 161-168.