ALL-REZ BFM - The consecutive trials for children with relapsed acute lymphoblastic leukemia

Klinische Padiatrie

Volumn 225, Issue SUPPL1, 2013, Pages

  Henze, G ^a   Stackelberg, A V ^a   Eckert, C ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

allogeneic stem cell transplantation; minimal residual disease; Relapsed ALL; targeted therapy

Indexed keywords

ANTHRACYCLINE; ASPARAGINASE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; IFOSFAMIDE; MERCAPTOPURINE; METHOTREXATE; OXAZAPHOSPHORINE; TIOGUANINE; VINCRISTINE; VINDESINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW METASTASIS; CANCER COMBINATION CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER REGRESSION; CANCER SURVIVAL; CENTRAL NERVOUS SYSTEM METASTASIS; CHILDHOOD CANCER; CHROMOSOME TRANSLOCATION; CLINICAL TRIAL (TOPIC); DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; DRUG TOLERABILITY; EVENT FREE SURVIVAL; GENETIC ASSOCIATION; GRANULOCYTIC SARCOMA; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOPHENOTYPING; LEUKEMIA CELL; ORCHIECTOMY; RECURRENT CANCER; RISK FACTOR; SHORT COURSE THERAPY; SURVIVAL RATE; TESTIS CANCER;

6-MERCAPTOPURINE; ADOLESCENT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ASPARAGINASE; BONE MARROW; CHILD; COMBINED MODALITY THERAPY; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; DISEASE-FREE SURVIVAL; EUROPE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; METHOTREXATE; MULTICENTER STUDIES AS TOPIC; NEOPLASM, RESIDUAL; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PREDNISONE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECURRENCE; REMISSION INDUCTION; RETREATMENT; SURVIVAL RATE; VINCRISTINE;

EID: 84878162160     PISSN: 03008630     EISSN: 14393824     Source Type: Journal    
DOI: 10.1055/s-0033-1337967     Document Type: Article

References (63)

1. Atkinson K., Thomas P. R., Peckham M. J. et al. Radiosensitivity of the acute leukaemic infiltrate. Eur J Cancer: 1976; 12 535 540
2. Bader P., Kreyenberg H., Henze G. H. et al. Prognostic value of minimal residual disease quantification before allogeneic stem-cell transplantation in relapsed childhood acute lymphoblastic leukemia: the ALL-REZ BFM Study Group. J Clin Oncol: 2009; 27 377 384
3. Barredo J. C., Devidas M., Lauer S. J. et al. Isolated CNS relapse of acute lymphoblastic leukemia treated with intensive systemic chemotherapy and delayed CNS radiation: a pediatric oncology group study. J Clin Oncol: 2006; 24 3142 3149 (Pubitemid 46638952)
4. Borgmann A., von Stackelberg A., Hartmann R. et al. Unrelated donor stem cell transplantation compared with chemotherapy for children with acute lymphoblastic leukemia in a second remission: a matched-pair analysis. Blood: 2003; 101 3835 3839 (Pubitemid 36857854)
5. Brecher M. L., Weinberg V., Boyett J. M. et al. Intermediate dose methotrexate in childhood acute lymphoblastic leukemia resulting in decreased incidence of testicular relapse. Cancer: 1986; 58 1024 1028 (Pubitemid 16046930)
6. Brochstein J. A., Kernan N. A., Groshen S. et al. Allogeneic bone marrow transplantation after hyperfractionated total-body irradiation and cyclophosphamide in children with acute leukemia. N Engl J Med: 1987; 317 1618 1624 (Pubitemid 18010465)
7. Buchanan G. R., Rivera G. K., Pollock B. H. et al. Alternating drug pairs with or without periodic reinduction in children with acute lymphoblastic leukemia in second bone marrow remission: A Pediatric Oncology Group study. Cancer: 2000; 88 1166 1174 (Pubitemid 30127679)
8. Buchanan G. R., Boyett J. M., Pollock B. H. et al. Improved treatment results in boys with overt testicular relapse during or shortly after initial therapy for acute lymphoblastic leukemia. A Pediatric Oncology Group study. Cancer: 1991; 68 48 55
9. Bührer C., Hartmann R., Fengler R. et al. Importance of effective central nervous system therapy in isolated bone marrow relapse of childhood acute lymphoblastic leukemia. Blood: 1994; 83 3468 3472 (Pubitemid 24175535)
10. Castillo L. A., Craft A. W., Kernahan J. et al. Gonadal function after 12-Gy testicular irradiation in childhood acute lymphoblastic leukaemia. Med Pediatr Oncol: 1990; 18 185 189 (Pubitemid 20150570)
11. Culbert S. J., Shuster J. J., Land V. J. et al. Remission induction and continuation therapy in children with their first relapse of acute lymphoid leukemia. A Pediatric Oncology Group study. Cancer: 1991; 67 37 42
12. Dahlke J., Kroger N., Zabelina T. et al. Comparable results in patients with acute lymphoblastic leukemia after related and unrelated stem cell transplantation. Bone Marrow Transplant: 2006; 37 155 163 (Pubitemid 43108807)
13. Domenech C., Mercier M., Plouvier E. et al. First isolated extramedullary relapse in children with B-cell precursor acute lymphoblastic leukaemia: results of the Cooprall-97 study. Eur J Cancer: 2008; 44 2461 2469
14. Dopfer R., Henze G., Bender-Götze C. et al. Allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia in second remission after intensive primary and relapse therapy according to the BFM- and CoALL-protocols: Results of the German Cooperative Study. Blood: 1991; 78 2780 2784
15. Dörffel W., Hartmann R., Schober S. et al. Drug resistance testing as a basis for tailored therapy in children with refractory or relapsed acute lymphoblastic leukemia. In: Kaspers G. J., Pieters R., Twentyman P. R., Weisenthal L. M., Veerman A. J. eds. Drug resistance in leukemia and lymphoma. Chur Harwood Academic Publishers: 1993; 353 357
16. Eapen M., Rubinstein P., Zhang M. J. et al. Comparable long-term survival after unrelated and HLA-matched sibling donor hematopoietic stem cell transplantations for acute leukemia in children younger than 18 months. J Clin Oncol: 2006; 24 145 151 (Pubitemid 46630506)
17. Eapen M., Zhang M. J., Devidas M. et al. Outcomes after HLA-matched sibling transplantation or chemotherapy in children with acute lymphoblastic leukemia in a second remission after an isolated central nervous system relapse: a collaborative study of the Children's Oncology Group and the Center for International Blood and Marrow Transplant Research. Leukemia: 2008; 22 281 286 (Pubitemid 351250532)
18. Eckert C., von Stackelberg A., Seeger K. et al. Minimal residual disease after induction is the strongest predictor of prognosis in intermediate risk relapsed ALL - Long-term results of trial ALL-REZ BFM P95/96. European Journal of Cancer: 2012; doi:pii: S0959-8049(12)00895-7. 10.1016/j.ejca.2012.11.010
19. Einsiedel H. G., von Stackelberg A., Hartmann R. et al. Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Munster Group 87. J Clin Oncol: 2005; 23 7942 7950 (Pubitemid 46657394)
20. Freeman A. I., Weinberg V., Brecher M. L. et al. Comparison of intermediate-dose methotrexate with cranial irradiation for the post-induction treatment of acute lymphocytic leukemia in children. N Engl J Med: 1983; 308 477 484 (Pubitemid 13195474)
21. Gassas A., Sung L., Saunders E. F. et al. Comparative outcome of hematopoietic stem cell transplantation for pediatric acute lymphoblastic leukemia following cyclophosphamide and total body irradiation or VP16 and total body irradiation conditioning regimens. Bone Marrow Transplant: 2006; 38 739 743 (Pubitemid 44756443)
22. Gassas A., Sung L., Saunders E. F. et al. Graft-versus-leukemia effect in hematopoietic stem cell transplantation for pediatric acute lymphoblastic leukemia: significantly lower relapse rate in unrelated transplantations. Bone Marrow Transplant: 2007; 40 951 955 (Pubitemid 350048193)
23. Gaynon P. S., Qu R. P., Chappell R. J. et al. Survival after relapse in childhood acute lymphoblastic leukemia: Impact of site and time to first relapse - the Children's Cancer Group Experience. Cancer. 1998; 82 1387 1395 (Pubitemid 28155403)
24. Gaynon P. S. Childhood acute lymphoblastic leukaemia and relapse. Br J Haematol: 2005; 131 579 587 (Pubitemid 43903802)
25. Grundy R. G., Leiper A. D., Stanhope R. et al. Survival and endocrine outcome after testicular relapse in acute lymphoblastic leukaemia. Arch Dis Child: 1997; 76 190 196 (Pubitemid 27132370)
26. Harker-Murray P. D., Thomas A. J., Wagner J. E. et al. Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous system. Biol Blood Marrow Transplant: 2008; 14 685 692 (Pubitemid 351664063)
27. Henze G. Chemotherapy for relapsed childhood acute lymphoblastic leukemia. Int J Pediatr Hematol Oncol: 1997; 5 199 213
28. Henze G., von Stackelberg A. Treatment of Relapsed Acute Lymphoblastic Leukemia. In: Pui C. H. ed. Treatment of Acute Leukemias New Directions for Clinical Research. Totova. USA Humana Press: 2002; 199 219
29. Henze G., Fengler R., Hartmann R. Chemotherapy for relapsed childhood acute lymphoblastic leukemia: Results of the BFM Study Group. Haematol Blood Transfus: 1994; 36 374 379
30. Henze G., Fengler R., Hartmann R. et al. Six-year experience with a comprehensive approach to the treatment of recurrent childhood acute lymphoblastic leukemia (ALL-REZ BFM 85). A relapse study of the BFM Group. Blood: 1991; 78 1166 1172
31. Herold R., Von Stackelberg A., Hartmann R. et al. Acute Lymphoblastic Leukemia- Relapse Study of the Berlin-Frankfurt-Munster Group (ALL-REZ BFM) Experience: Early Treatment Intensity Makes the Difference. J Clin Oncol. 2004; 22 569 570
32. Hof J., Krentz S., Van Schewick C. et al. Mutations and deletions of the TP53 gene predict non-response and poor outcome in relapsed childhood acute lymphoblastic leukemia. J Clin Oncol: 2011
33. Hong D., Gupta R., Ancliff P. et al. Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science: 2008; 319 336 339
34. Kaspers G. J., Pieters R., Klumper E. et al. Glucocorticoid resistance in childhood leukemia. Leuk Lymphoma: 1994; 13 187 201 (Pubitemid 24141325)
35. Kawamura M., Kikuchi A., Kobayashi S. et al. Mutations of the p53 and ras genes in childhood t(1;19)-acute lymphoblastic leukemia. Blood: 1995; 85 2546 2552
36. Klumper E., Pieters R., Veerman A. J. et al. In vitro cellular drug resistance in children with relapsed/refractory acute lymphoblastic leukemia. Blood: 1995; 86 3861 3868
37. Krentz S., Hof J., Mendioroz A. et al. Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia. Leukemia 2012 13. 10.1038/leu.2012.155
38. Kreyenberg H., Eckert C., Yarkin Y. et al. Immunoglobulin and T-cell receptor gene rearrangements as PCR-based targets are stable markers for monitoring minimal residual disease in acute lymphoblastic leukemia after stem cell transplantation. Leukemia: 2009; 23 1355 1358
39. Land V. J., Thomas P. R., Boyett J. M. et al. Comparison of maintenance treatment regimens for first central nervous system relapse in children with acute lymphocytic leukemia. A Pediatric Oncology Group study. Cancer: 1985; 56 81 87 (Pubitemid 15056685)
40. Langlands K., Craig J. I., Anthony R. S. et al. Clonal selection in acute lymphoblastic leukaemia demonstrated by polymerase chain reaction analysis of immunoglobulin heavy chain and T-cell receptor delta chain rearrangements. Leukemia: 1993; 7 1066 1070 (Pubitemid 23230990)
41. Lawson S. E., Harrison G., Richards S. et al. The UK experience in treating relapsed childhood acute lymphoblastic leukaemia: A report on the Medical Research Council UKALLR1 study. Br J Haematol: 2000; 108 531 543 (Pubitemid 30196250)
42. Leiper A. D., Grant D. B., Chessells J. M. Gonadal function after testicular radiation for acute lymphoblastic leukaemia. Arch Dis Child: 1986; 61 53 56 (Pubitemid 16124850)
43. MacMillan M. L., Davies S. M., Nelson G. O. et al. Twenty years of unrelated donor bone marrow transplantation for pediatric acute leukemia facilitated by the National Marrow Donor Program. Biol Blood Marrow Transplant: 2008; 14 16 22
44. Morland B. J., Shaw P. J. Induction toxicity of a modified Memorial Sloan-Kettering-New York II Protocol in children with relapsed acute lymphoblastic leukemia: A single institution study. Med Pediatr Oncol: 1996; 27 139 144 (Pubitemid 26282092)
45. Moussalem M., Esperou Bourdeau H., Devergie A. et al. Allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia in second remission: Factors predictive of survival, relapse and graft-versus-host disease. Bone Marrow Transplant: 1995; 15 943 947
46. Nachman J., Palmer N. F., Sather H. N. et al. Open-wedge testicular biopsy in childhood acute lymphoblastic leukemia after two years of maintenance therapy: Diagnostic accuracy and influence on outcome - a report from Children's Cancer Study Group. Blood: 1990; 75 1051 1055 (Pubitemid 20086808)
47. Pui C. H., Bowman W. P., Ochs J. et al. Cyclic combination chemotherapy for acute lymphoblastic leukemia recurring after elective cessation of therapy. Med Pediatr Oncol: 1988; 16 21 26 (Pubitemid 18055259)
48. Raetz E. A., Borowitz M. J., Devidas M. et al. Reinduction platform for children with first marrow relapse of acute lymphoblastic Leukemia: A Children's Oncology Group Study[corrected]. J Clin Oncol: 2008; 26 3971 3978
49. Ritchey A. K., Pollock B. H., Lauer S. J. et al. Improved survival of children with isolated CNS relapse of acute lymphoblastic leukemia: A pediatric oncology group study. J Clin Oncol: 1999; 17 3745 3752
50. Rivera G. K., Zhou Y., Hancock M. L. et al. Bone marrow recurrence after initial intensive treatment for childhood acute lymphoblastic leukemia. Cancer: 2005; 103 368 376 (Pubitemid 40129297)
51. Roy A., Cargill A., Love S. et al. Outcome after first relapse in childhood acute lymphoblastic leukaemia - lessons from the United Kingdom R2 trial. Br J Haematol: 2005; 130 67 75 (Pubitemid 40979134)
52. Sadowitz P. D., Smith S. D., Shuster J. et al. Treatment of late bone marrow relapse in children with acute lymphoblastic leukemia: A Pediatric Oncology Group study. Blood: 1993; 81 602 609 (Pubitemid 23040849)
53. Schultz K. R., Bowman W. P., Aledo A. et al. Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study. J Clin Oncol: 2009; 27 5175 5181
54. Seeger K., Adams H. P., Buchwald D. et al. TEL-AML1 fusion transcript in relapsed childhood acute lymphoblastic leukemia. The Berlin-Frankfurt-Munster Study Group. Blood: 1998; 91 1716 1722 (Pubitemid 28110337)
55. Szczepanski T. Why and how to quantify minimal residual disease in acute lymphoblastic leukemia? Leukemia: 2007; 21 622 626 (Pubitemid 46444543)
56. Tallen G., Ratei R., Mann G. et al. Long-term outcome in children with relapsed acute lymphoblastic leukemia after time-point and site-of-relapse stratification and intensified short-course multidrug chemotherapy: results of trial ALL-REZ BFM 90. J Clin Oncol: 2010; 28 2339 2347
57. Tsurusawa M., Yumura-Yagi K., Ohara A. et al. Survival outcome after the first central nervous system relapse in children with acute lymphoblastic leukemia: a retrospective analysis of 79 patients in a joint program involving the experience of three Japanese study groups. Int J Hematol: 2007; 85 36 40 (Pubitemid 46193288)
58. Weyman C., Graham-Pole J., Emerson S. et al. Use of cytosine arabinoside and total body irradiation as conditioning for allogeneic marrow transplantation in patients with acute lymphoblastic leukemia: a multicenter survey. Bone Marrow Transplant: 1993; 11 43 50 (Pubitemid 23086846)
59. Wheeler K., Richards S., Bailey C. et al. Comparison of bone marrow transplant and chemotherapy for relapsed childhood acute lymphoblastic leukaemia: The MRC UKALL X experience. Medical Research Council Working Party on Childhood Leukaemia. Br J Haematol: 1998; 101 94 103 (Pubitemid 28197782)
60. Wofford M. M., Smith S. D., Shuster J. J. et al. Treatment of occult or late overt testicular relapse in children with acute lymphoblastic leukemia: A Pediatric Oncology Group study. J Clin Oncol: 1992; 10 624 630
61. Wolfrom C., Hartmann R., Brühmüller S. et al. Similar outcome on boys with isolated and combined testicular acute lymphoblastic leukemia relapse after stratified BFM salvage therapy. Haematol Blood Transfus: 1997; 38 647 651 (Pubitemid 127005151)
62. Uderzo C., Rondelli R., Dini G. et al. High-dose vincristine, fractionated total-body irradiation and cyclophosphamide as conditioning regimen in allogeneic and autologous bone marrow transplantation for childhood acute lymphoblastic leukaemia in second remission: A 7-year Italian multicentre study. Br J Haematol: 1995; 89 790 797
63. Uderzo C., Grazia Zurlo M., Adamoli L. et al. Treatment of isolated testicular relapse in childhood acute lymphoblastic leukemia: An Italian multicenter study. J Clin Oncol: 1990; 8 672 677 (Pubitemid 20127252)