Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 21, 2013, Pages 8555-8560

  Du, Li ^a,e   Bergsneider, Marvin ^a   Mirsadraei, Leili ^a,f   Young, Steven H ^a   Jonker, Johan W ^b   Downes, Michael ^c   Yong, William H ^a   Evans, Ronald M ^c,d   Heaney, Anthony P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; MITOGEN ACTIVATED PROTEIN KINASE; ORPHAN NUCLEAR RECEPTOR; PROOPIOMELANOCORTIN; TESTICULAR ORPHAN NUCLEAR RECEPTOR 4; UNCLASSIFIED DRUG;

ACTH SECRETING ADENOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORTICOTROPIN RELEASE; CUSHING DISEASE; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HORMONE SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; TUMOR CELL LINE; TUMOR GROWTH; TUMOR INVASION;

ACTH-SECRETING PITUITARY ADENOMA; ADRENOCORTICOTROPIC HORMONE; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CORTICOSTERONE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; NEOPLASM PROTEINS; PITUITARY ACTH HYPERSECRETION; PRO-OPIOMELANOCORTIN; RECEPTORS, STEROID; RECEPTORS, THYROID HORMONE; RESPONSE ELEMENTS; TRANSCRIPTIONAL ACTIVATION;

EID: 84878145552     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1306182110     Document Type: Article

References (29)

1. Ezzat S, et al. (2004) The prevalence of pituitary adenomas: a systematic review. Cancer 101(3): 613-619.
2. Newell-Price J, Bertagna X, Grossman AB, Nieman LK (2006) Cushing's syndrome. Lancet 367(9522): 1605-1617.
3. Grossman A (1992) What is the cause of Cushing's disease? Clin Endocrinol (Oxf) 36(5): 451-452.
4. Krieger DT (1983) Physiopathology of Cushing's disease. Endocr Rev 4(1): 22-43.
5. Tritos NA, Biller BM, Swearingen B; Medscape (2011) Management of Cushing disease. Nat Rev Endocrinol 7(5): 279-289.
6. Liubinas SV, Porto LD, Kaye AH (2011) Management of recurrent Cushing's disease. J Clin Neurosci 18(1): 7-12.
7. Praw SS, Heaney AP (2009) Medical treatment of Cushing's disease: Overview and recent findings. Int J Gen Med 2: 209-217.
8. Pedroncelli AM (2010) Medical treatment of Cushing's disease: somatostatin analogues and pasireotide. Neuroendocrinology 92(Suppl 1): 120-124.
9. Pivonello R, et al. (2009) The medical treatment of Cushing's disease: effectiveness of chronic treatment with the dopamine agonist cabergoline in patients unsuccessfully treated by surgery. J Clin Endocrinol Metab 94(1): 223-230.
10. Pecori Giraldi F, et al. (2012) Potential role for retinoic acid in patients with Cushing's disease. J Clin Endocrinol Metab 97(10): 3577-3583.
11. Chang C, et al. (1994) Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. Proc Natl Acad Sci USA 91(13): 6040-6044.
12. Lee YF, Pan HJ, Burbach JP, Morkin E, Chang C (1997) Identification of direct repeat 4 as a positive regulatory element for the human TR4 orphan receptor. A modulator for the thyroid hormone target genes. J Biol Chem 272(18): 12215-12220.
13. Young WJ, Lee YF, Smith SM, Chang C (1998) A bidirectional regulation between the TR2/TR4 orphan receptors (TR2/TR4) and the ciliary neurotrophic factor (CNTF) signaling pathway. J Biol Chem 273(33): 20877-20885.
14. Lee CH, Chinpaisal C, Wei LN (1998) A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4. J Biol Chem 273(39): 25209-25215.
15. Xie S, et al. (2009) TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation. Proc Natl Acad Sci USA 106(32): 13353-13358.
16. Liu NC, et al. (2007) Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis. Diabetes 56(12): 2901-2909.
17. Kim E, et al. (2003) Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster. J Biol Chem 278(47): 46919-46926.
18. Tanabe O, et al. (2007) Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4. EMBO J 26(9): 2295-2306.
19. O'Geen H, et al. (2010) Genome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes. BMC Genomics 11:689.
20. Chen LM, et al. (2008) Subfertility with defective folliculogenesis in female mice lacking testicular orphan nuclear receptor 4. Mol Endocrinol 22(4): 858-867.
21. van Wijk PA, van Neck JW, Rijnberk A, Croughs RJ, Mol JA (1995) Proliferation of the murine corticotropic tumour cell line AtT20 is affected by hypophysiotrophic hormones, growth factors and glucocorticoids. Mol Cell Endocrinol 111(1): 13-19.
22. Huq MD, Gupta P, Tsai NP, Wei LN (2006) Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation. Mol Cell Proteomics 5(11): 2072-2082.
23. Hassan-Smith ZK, et al. (2012) Outcome of Cushing's disease following transsphenoidal surgery in a single center over 20 years. J Clin Endocrinol Metab 97(4): 1194-1201.
24. Bertagna X, Guignat L (2012) [Recent progress in the treatment of Cushing's disease]. Ann Endocrinol (Paris) 73(2): 107-110.
25. Kim E, et al. (2007) TR4 orphan nuclear receptor functions as an apoptosis modulator via regulation of Bcl-2 gene expression. Biochem Biophys Res Commun 361(2): 323-328.
26. Koritschoner NP, et al. (2001) The nuclear orphan receptor TR4 promotes proliferation of myeloid progenitor cells. Cell Growth Differ 12(11): 563-572.
27. Lalevée S, Ferry C, Rochette-Egly C (2010) Phosphorylation control of nuclear receptors. Methods Mol Biol 647: 251-266.
28. Collins LL, et al. (2004) Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4. Proc Natl Acad Sci USA 101(42): 15058-15063.
29. Weigel NL, Moore NL (2007) Kinases and protein phosphorylation as regulators of steroid hormone action. Nucl Recept Signal 5:e005.