Underreporting of Dengue-4 in Brazil Due to Low Sensitivity of the NS1 Ag Test in Routine Control Programs

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Sea, Vanessa Ramos Faria ^a   Cruz, Ana Cecília Ribeiro ^b,c   Gurgel, Ricardo Q ^a   Nunes, Bruno Tardelli Diniz ^b   Silva, Eliana Vieira Pinto ^b   Dolabella, Silvio S ^a   Santos, Roseli La Corte dos ^a  

^a FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

^b INSTITUTO EVANDRO CHAGAS   (Brazil)

^c UNIVERSIDADE DO ESTADO DO PARÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTRUCTURAL PROTEIN 1;

ARTICLE; BLOOD SAMPLING; BRAZIL; DENGUE; DENGUE VIRUS 4; DIAGNOSTIC ERROR; DISEASE ASSOCIATION; DISEASE SURVEILLANCE; FALSE NEGATIVE RESULT; HEALTH PROGRAM; HUMAN; INFECTION CONTROL; MICROPARTICLE ENZYME IMMUNOASSAY; NONHUMAN; SCREENING TEST; SECONDARY INFECTION; SENSITIVITY AND SPECIFICITY; SEROTYPE; VIRUS DETECTION; VIRUS ISOLATION;

ANTIBODIES, VIRAL; ANTIGENS, VIRAL; BRAZIL; DENGUE; DENGUE VIRUS; DIAGNOSTIC ERRORS; EPIDEMICS; HUMANS; INCIDENCE; REAGENT KITS, DIAGNOSTIC; SENSITIVITY AND SPECIFICITY; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84878144939     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064056     Document Type: Article

References (14)

1. WHO (2009) Dengue: Guidelines for treatment, prevention and control. Geneva: World Health Organization. 147 p.
2. Osanai CH, Rosa AP, Tang AT, Amaral RS, Passos ADC, et al. (1983) Surto de dengue em Boa Vista Roraima. Rev Inst Med Trop São Paulo 25: 53-54.
3. Nogueira RM, Miagostovich MP, Schatzmayr HG, Santos FB, Araujo ESM, et al. (1999) Dengue in the State of Rio de Janeiro, Brazil, 1986-1998. Mem Inst Oswaldo Cruz 94(3): 297-304.
4. Teixeira MG, Costa MCN, Barreto ML, Mota E, (2005) Dengue and dengue hemorrhagic fever epidemics in Brazil: what research is needed based on trends, surveillance, and control experiences? Cad Saúde Pública 21: 1307-1315.
5. Siqueira JB Jr, Martelli CMT, Coelho GE, Simplício AC, Hatch DL, (2005) Dengue and dengue hemorrhagic fever, Brazil, 1981-2002. Emerg Infect Dis 11(1): 48-53.
6. Temporão JG, Penna GO, Carmo EH, Coelho GE, Azevedo RSS, et al. (2011) Dengue virus serotype 4, Roraima State, Brazil. Emerg Infect Dis 17: 938-940.
7. Souza RP, Rocco IM, Maeda AY, Spenassatto C, Bisordi I, et al. (2011) Dengue Virus Type 4 Phylogenetics in Brazil 2011: Looking beyond the veil. PLoS Negl Trop Dis 5(12): e1439.
8. Lanciotti RS, Calisher CH, Gubler DJ, Chang GJ, Vorndam AV, (1992) Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol 30(3): 545-551.
9. Gubler DJ, Kuno G, Sather GE, Velez M, Oliver A, (1984) Mosquito cell cultures and specific monoclonal antibodies in surveillance for dengue viruses. Am J Trop Med Hyg 33(1): 158-165.
10. Hang VT, Nguyet NM, Trung DT, Tricou V, Yoksan S, et al. (2009) Diagnostic accuracy of NS1 ELISA and lateral flow rapid tests for dengue sensivity, specificity and relationship to viraemia and antibody responses. Plos Negl Trop Dis 3(1): e360.
11. Guzman MG, Jaenisch T, Gaczkowski R, Ty Hang VT, Sekaran SD, et al. (2010) Multi-country evaluation of the sensitivity and specificity of two commercially-available NS1 ELISA assays for dengue diagnosis. PLoS Negl Trop Dis 4(8): e811.
12. Lima MRQ, Nogueira RMR, Schatzmayr HG, Santos FB, (2010) Comparison of three commercially available dengue NS1 antigen capture assays for acute diagnosis of dengue in Brazil. PLoS Negl Trop Dis 4(7): e738.
13. Koraka P, Burghoorn-Maas CP, Falconar A, Setiati TE, Djamiatun K, et al. (2003) Detection of immune-complex-dissociated nonstructural-1 antigen in patients with acute dengue virus infections. J Clin Microbiol 41(9): 4154-4159.
14. Ministério da Saúde/Secretaria de Vigilância em Saúde MS/SVS (2012). Incidência de Dengue. Brasil, Grandes Regiões e Unidades Federadas, 1990 a 2011 Available at URL: http://portal.saude.gov.br/portal/arquivos/pdf/incidencia_de_dengue_brasil_1990_2011_21_06_12.pdf.