Micro-structured hydroxyapatite microspheres for local delivery of alendronate and BMP-2 carriers

Materials Letters

Volumn 105, Issue , 2013, Pages 136-139

  Lee, Jin Hyung ^a   Ko, Il Hwan ^a   Jeon, Seong Hyun ^b   Chae, Ji Hwa ^b   Chang, Jeong Ho ^a  

^a Korea Institute of Ceramic Engineering and Technology (KICET)   (South Korea)

^b Hans Biomed Corporation   (South Korea)

Author keywords

Alendronate; Drug carrier; Hydroxyapatite; Local delivery; Osteoporosis

Indexed keywords

ALENDRONATE; DRUG CARRIER; EMULSIFICATION PROCESS; ENZYMATIC DECOMPOSITION; HYDROXYAPATITE MICROSPHERES; LOCAL DELIVERY; MICROSTRUCTURED MICROSPHERES; OSTEOPOROSIS;

EMULSIFICATION; HYDROXYAPATITE; MICROEMULSIONS; SCANNING ELECTRON MICROSCOPY; SINTERING; UREA;

MICROSPHERES;

EID: 84878125560     PISSN: 0167577X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.matlet.2013.04.082     Document Type: Article

References (16)

1. Y Li, and PI Lee A new bioerodible system for sustained local drug delivery based on hydrolytically activated in situ macromolecular association Int J Pharm 383 2010 45 52
2. B Kundu, C Soundrapandian, SK Nandi, P Mukherjee, N Dandapat, and S Roy Development of new localized drug delivery system based on ceftriaxone-sulbactam composite drug impregnated porous hydroxyapatite: a systematic approach for in vitro and in vivo animal trial Pharm Res 27 2010 1659 1676
3. JH Lin, I-W Chen, and FA delLuna On the absorption of alendronate in rats J Pharm Sci 83 1994 1741 1746
4. BJ Gertz, SD Holland, WF Kline, BK Matuszewski, and AG Porras Clinical pharmacology of alendronate sodium Osteopor Int 3 1993 513 516
5. S Adami, M Mian, P Gatti, M Rossini, N Zamberlan, and F Bertoldo Effects of two oral doses of alendronate in the treatment of Paget's disease of bone Bone 15 1994 415 417 (Pubitemid 24168014)
6. W Huang, Y Wang, I Ren, C Du, and X Shi A novel PHBV/HA microsphere releasing system loaded with alendronate Mater Sci Eng 29 2009 2221 2225
7. X Shi, Y Wang, L Ren, Y Gong, and D-A Wang Enhancing alendronate release from a novel PLGA/Hydroxyapatite microspheric system for bone repairing applications Pharm Res 26 2009 422 430
8. CW Kim, Y Yun, HJ Lee, Y Hwang, IK Kwon, and SC Lee In situ fabrication of alendronate-loaded calcium phosphate microspheres: controlled release for inhibition of osteoclastogenesis J Control Release 147 2010 45 53
9. LL Hench, and JM Polak Third-generation biomedical materials Science 295 2002 1014 1017
10. T Koshino, T Murase, T Takagi, and T Saito New bone formation around porous hydroxyapatite wedge implanted in opening wedge high tibial osteotomy in patients with osteoarthritis Biomaterials 22 2001 1579 1582 (Pubitemid 32564853)
11. M Ngiam, S Liao, AJ Patil, Z Cheng, CK Chan, and S Ramakrishna The fabrication of nano-hydroxyapatite on PLGA and PLGA/collagen nanofibrous composite scaffolds and their effects in osteoblastic behavior for bone tissue engineering Bone 45 2009 4 16
12. AL Rossi, IC Barreto, WQ Maciel, FP Rosa, MH Rocha-Leäo, and J Werckmann Ultrastructure of regenerated bone mineral surrounding hydroxyapatite-alginate composite and sintered hydroxyapatite Bone 50 2012 301 310
13. A Veis A window on biomineralization Science 307 2005 1419 1420 (Pubitemid 40321927)
14. Korea Food & Drug Administration, 2011-58; 2011.
15. JH Lin Biosphosphonates: a review of their pharmacokinetic properties Bone 18 1996 75 85 (Pubitemid 26092586)
16. E Boanini, M Gazzano, K Rubini, and A Bigi Composite nanocrystals provide new insight on alendronate interaction with hydroxyapatite structure Adv Mater 19 2007 2499 2502 (Pubitemid 47481802)