Microbiological Diagnosis of Respiratory Infections in the Immunocompromised

Pulmonary Infection in the Immunocompromised Patient: Strategies for Management

Volumn , Issue , 2009, Pages 29-52

  Ieven, Margareta ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Antigen detection by latex agglutination or immuno fluorescence (DIF); Epstein Barr virus (EBV) ubiquitous human herpes virus; HIV and Pneumocystis jirovecii; HIV infection and mycobacterium tuberculosis; HIV infection and non tuberculous mycobacteria (NTM); Immunodeficiency and herpes simplex virus infection; Mycobacterium tuberculosis Direct Test (MTD); Respiratory infections and microbiological diagnosis

Indexed keywords

EID: 84878038633     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470714171.ch2     Document Type: Chapter

References (116)

1. Afessa, B. and Peters, S.G. (2006) Major complications following hematopoietic stem cell transplantation, semin respir. Critical Care Medicine, 27, 297-309.
2. Allander, T., Tammi, M.T., Eriksson, M. et al. (2005) Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proceedings of the National Academy of Sciences of the United States of America, 102, 12891-12896.
3. American Thoracic Society (2007) Diagnosis and treatment of disease caused by Nontuberculous Mycobacteria. American Journal of Respiratory and Critical Care Medicine, 156, S1-S25.
4. Ascioglu, S., Rex, J.H., de Pauw, B. et al. (2002) Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clinical Infectious Diseases, 34, 7-14.
5. Baldanti, F., Grossi, P., Furione, M. et al. (2000) High levels of Epstein-Barr virus DNA in blood of solid-organ transplant recipients and their value in predicting posttransplant lymphoproliferative disorders. Journal of Clinical Microbiology, 38, 613-619.
6. Barron, M.A. and Weinberg, A. (2005) Common viral infections in transplant recipients, Part 2. Respiratory viruses, polyomaviruses, and erythroviruses. Clinical Microbiology Newsletter, 27, 115-122.
7. Bhorade, S.M., Sandesara, C., Garrity, E.R. et al. (2001) Quantification of cytomegalovirus (CMV) viral load by the hybrid capture assay allows for early detection of CMV disease in lung transplant recipients. The Journal of Heart and Lung Transplantation, 20, 928-934.
8. Bochud, P.Y., Calandra, T. and Francioli, P. (1994) Bacteremia due to viridans streptococci in neutropenic patients: A review. The American Journal of Medicine, 97, 256-264.
9. Boeckh, M., Huang, M., Ferrenberg, J. et al. (2004) Optimization of quantitative detection of cytomegalovirus DNA in plasma by real-time PCR. Journal of Clinical Microbiology, 42, 1142-1148.
10. Boivin, G., De Serres, G., Hamelin, M.E. et al. (2007) An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility. Clinical Infectious Diseases, 44(9), 1152-1158. Epub 2007 Mar 28.
11. Boyton, R.J. (2005) Infectious lung complications in patients with HIV/AIDS. Current Opinion in Pulmonary Medicine, 11, 203-207.
12. Brancart, F., Rodriguez-Villalobos, H., Fonteyne, P.A. et al. (2005) Quantitative TaqMan PCR for detection of Pneumocystis jiroveci. Journal of Microbiological Methods, 61, 381-387.
13. Bruynseels, P., Jorens, P.G., Demey, H.E. et al. (2003) Herpes simplex virus in the respiratory tract of critical care patients: a prospective study. Lancet, 362, 1536-1541.
14. Caliendo, A.M., Ingersoll, J., Fox-Canale, A.M. et al. (2007) Evaluation of real-time PCR laboratory-developed tests using analyte-specific reagents for cytomegalovirus quantification. Journal of Clinical Microbiology, 45, 1723-1727.
15. Calzo, L., Manfredi, R. and Chiodo, F. (2003) Stenotrophomonas (Xanthomonas) maltophilia as an emerging opportunistic pathogen in association with HIV infection: a 10-year surveillance study. Infection, 31, 155-161.
16. CDC (2000) Update: Nucleic acid amplification tests fortuberculosis. Morbidity and Mortality Weekly Report, 49, 593-594.
17. Chakrabarti, S. (2007) Adenovirus infections after hematopoietic stem cell transplantation: still unravelling the story. Clinical Infectious Diseases, 45, 066-968.
18. Chakrabarti, S., Mautner, V., Osman, H. et al. (2002) Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression and immune recovery. Blood, 100, 1619-1627.
19. Chemaly, R.F., Ghosh, S., Bodey, G. et al. (2006) Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center. Medicine (Baltimore), 85, 278-287.
20. Cohen, J.M., Cooper, N., Chakrabarti, S. et al. (2007) EBV-related disease following haematopoietic stem cell transplantation with reduced intensity conditioning. Leukemia & Lymphoma, 48, 256-269.
21. Cordonnier, C. and Cunningham, I. (1998) Transplant Infections (eds R.A. Bowden, P. Ljungman and C.V. Paya), Lippincott-Raven, Philadelphia, USA, pp. 105-120.
22. Covalciuc, K.A., Webb, K.H. and Carlson, C.A. (1999) Comparison of four clinical specimen types for detection of influenza A and B viruses by optical immunoassay (FLU OIA test) and cell culture methods. Journal of Clinical Microbiology, 37, 3971-3974.
23. Crump, J.A., Tanner, D.C., Mirrett, S. et al. (2003) Controlled comparison of BACTEC 13A, MYCO/F LYTIC, BacT/ALERT MB, and ISOLATOR 10 systems for detection of mycobacteremia. Journal of Clinical Microbiology, 41, 1987-1990.
24. Cunha, B.A., Eisenstein, L.E., Dillard, T. and Krol, V. (2007) Herpes simplex virus (HSV) pneumonia in a heart transplant: diagnosis and therapy. Heart Lung, 36, 72-78.
25. Daley, C.L., Small, P.M., Schecter, G.F. et al. (1992) An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus. An analysis using restriction-fragment-length polymorphisms. The New England Journal of Medicine, 326, 231-235.
26. Dare, R., Sanghavi, S., Bullotta, A. et al. (2007) Diagnosis of human metapneumovirus infection in immunosuppressed lung transplant recipients and children evaluated for pertussis. Journal of Clinical Microbiology, 45, 48-52.
27. Di Perri, G., Cruciani, M., Danzi, M.C. et al. (1989) Nosocomial epidemic of active tuberculosis among HIV-infected patients. Lancet, 2, 1502-1504.
28. Digby, J., Kalbfleisch, J., Glenn, A. et al. (2003) Serum glucan levels are not specific for presence of fungal infections in intensive care unit patients. Clinical and Diagnostic Laboratory Immunology, 10, 882-885.
29. Dignan, F., Alvares, C., Riley, U. et al. (2006) Parainfluenza type 3 infection post stem cell transplant: high prevalence but low mortality. The Journal of Hospital Infection, 63, 452-458.
30. Donnelly, J.P. (2006) Polymerase chain reaction for diagnosing invasive aspergillosis: getting closer but still a ways to go. Clinical Infectious Diseases, 42, 487-489.
31. Dykewicz, C.A. (2001) Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients: focus on community respiratory virus infections. Biology of Blood and Marrow Transplantation, 7, 19S-22S.
32. Elliott, A.M., Namaambo, K., Allen, B.W. et al. (1993) Negative sputum smear results in HIV-positive patients with pulmonary tuberculosis in Lusaka, Zambia. Tubercle and Lung Disease, 74, 191-194.
33. Emery, V.C., Sabin, C.A., Cope, A.V. et al. (2000) Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation. Lancet, 355, 2032-2036.
34. Eng, R.H., Bishburg, E., Smith, S.M. and Mangia, A. (1989) Diagnosis of Mycobacterium bacteremia in patients with acquired immunodeficiency syndrome by direct examination of blood films. Journal of Clinical Microbiology, 27, 768-769.
35. Enzensberger, R., Hunfeld, K.P., Krause, M. et al. (1999) Mycobacterium malmoense infections in immunocompetent patients. European Journal ofClinical Microbiology & Infectious Diseases, 18, 579-581.
36. Feuchtinger, T., Lang, P. and Handgretinger, R. (2007) Adenovirus infection after allogeneic stem cell transplantation. Leukemia & Lymphoma, 48, 244-255.
37. Fishman, J.A., Emery, V., Freeman, R. et al. (2007) Cytomegalovirus in transplantation-challenging the status quo. Clinical Transplantation, 21, 149-158.
38. Gassas, A., Grant, R., Richardson, S. et al. (2004) Predictors of viridans streptococcal shock syndrome in bacteremic children with cancer and stem-cell transplant recipients. Journal of Clinical Oncology, 22, 1222-1227.
39. Gentile, G., Picardi, A., Capobianchi, A. et al. (2006) A prospective study comparing quantitative Cytomegalovirus (CMV) polymerase chain reaction in plasma and pp65 antigenemia assay in monitoring patients after allogeneic stem cell transplantation. BMC Infectious Diseases, 6, 167.
40. Getahun, H., Harrington, M., O'Brien, R. and Nunn, P. (2007) Diagnosis of smear-negative pulmonary tuberculosis in people with HIV infection or AIDS in resource-constrained settings: informing urgent policy changes. Lancet, 369, 2042-2049.
41. Ghisetti, V., Barbui, A., Franchello, A. et al. (2004) Quantitation of cytomegalovirus DNA by the polymerase chain reaction as a predictor of disease in solid organ transplantation. Journal of Medical Virology, 73, 223-229.
42. Gruteke, P., Glas, A.S., Dierdorp, M. et al. (2004) Practical implementation of a multiplex PCR for acute respiratory tract infections in children. Journal of Clinical Microbiology, 42, 5596-5603.
43. Gunson, R.N., Collins, T.C. and Carman, W.F. (2005) Real-time RT-PCR detection of 12 respiratory viral infections in four triplex reactions. Journal of Clinical Virology, 33, 341-344.
44. Haller, A., von Segesser, L., Baumann, P.C. and Krause, M. (1995) Severe respiratory insufficiency complicating Epstein-Barr virus infection: Case report and review. Clinical Infectious Diseases, 21, 206-209.
45. Hanna, B.A., Walters, S.B., Bonk, S.J. and Tick, L.J. (1995) Recovery of mycobacteria from blood in mycobacteria growth indicator tube and Lowenstein-Jensen slant after lysis-centrifugation. Journal of Clinical Microbiology, 33, 3315-3316.
46. Harries, A.D., Maher, D. and Nunn, P. (1998) An approach to the problems of diagnosing and treating adult smear-negative pulmonary tuberculosis in high-HIV-prevalence settings in sub-Saharan Africa. Bulletin of the World Health Organization, 76, 651-662.
47. Henrickson, K.J. (2004) Advances in the laboratory diagnosis of viral respiratory disease. The Pediatric Infectious Disease Journal, 23, S6-S10.
48. Henry, M.T., Inamdar, L., O'Riordain, D. et al. (2004) Nontuberculous mycobacteria in non-HIV patients: epidemiology, treatment and response. The European Respiratory Journal, 23, 741-746.
49. Hughes, W.T. (1989) Current issues in the epidemiology, transmission, and reactivation of Pneumocystis carinii. Semin Respir Infect, 13, 283-288.
50. Ieven, M. (2007) Microbiological diagnosis of community acquired pneumonia, in Community Acquired Pneumonia (ed. A. Torres), John Wiley and Sons Ltd, United Kingdom, 43-67.
51. Ison, M.G., Hayden, F.G., Kaiser, L. et al. (2003) Rhinovirus infections in hematopoietic stem cell transplant recipients with pneumoni. Clinical Infectious Diseases, 36, 1139-1143.
52. Karstaedt, A.S., Jones, N., Khoosal, M. and Crewe-Brown, H.H. (1998) The bacteriology of pulmonary tuberculosis in a population with high human immunodeficiency virus seroprevalence. International Journal of Tuberculosis and Lung Disease, 2, 312-316.
53. Kawazu, M., Kanda, Y., Nannya, Y. et al. (2004) Prospective comparison of the diagnostic potential of real-time PCR, double-sandwich enzyme-linked immunosorbent assay for galactomannan, and a (1 → 3)-beta-D-glucan test in weekly screening for invasive aspergillosis in patients with hematological disorders. Journal of Clinical Microbiology, 42, 2733-2741.
54. Kesebir, D., Vazquez, M., Weibel, C. et al. (2006) Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus. The Journal of Infectious Diseases, 94, 1276-1282.
55. Khushalani, N.I., Bakri, F.G., Wentling, D. et al. (2001) Respiratory syncytial virus infection in the late bone marrow transplant period: report of three cases and review. Bone Marrow Transplantation, 27, 1071-1073.
56. Kleines, M., Scheithauer, S., Rackowitz, A. et al. (2007) High prevalence of human bocavirus detected in young children with severe acute lower respiratory tract disease by use of a standard PCR protocol and a novel real-time PCR protocol. Journal of Clinical Microbiology, 45, 1032-1034.
57. Koetz, A., Nilsson, P., Linden, M. et al. (2006) Detection of human coronavirus NL63, human metapneumovirus and respiratory syncytial virus in children with respiratory tract infections in south-west Sweden. Clinical Microbiology and Infection, 12, 1089-1096.
58. Kotloff, R.M., Ahya, V.N. and Crawford, S.W. (2004) Pulmonary complications of solid organ and hematopoietic stem cell transplantation. American Journal of Respiratory and Critical Care Medicine, 170, 22-48.
59. Kupfer, B., Vehreschild, J., Cornely, O. et al. (2006) Severe pneumonia and human bocavirus in adult. Emerging Infectious Diseases, 12, 1614-1616.
60. La Rosa, A.M., Champlin, R.E., Mirza, N. et al. (2001) Adenovirus infections in adult recipients of blood and marrow transplant. Clinical Infectious Diseases, 32, 871-876.
61. Landry, M.L., Cohen, S. and Ferguson, D. (2000) Impact of sample type on rapid detection of influenza virus A by cytospin-enhanced immunofluorescence and membrane enzyme-linked immunosorbent assay. Journal of Clinical Microbiology, 38, 429-430.
62. Lee, B.E., Robinson, J.L. and Khurana, V. (2006) Enhanced detection of viral and atypical bacterial pathogens in lower respiratory tract samples with nucleic acid amplification tests. Journal of Medical Virology, 78, 702-710.
63. Li, C.R., Greenberg, P.D., Gilbert, M.J. et al. (1994) Recovery of HLA-restricted cytomegalovirus (CMV)-specific T-cell responses after allogeneic bone marrow transplant: correlation with CMVdisease and effect of ganciclovir prophylaxis. Blood, 83, 1971-1979.
64. Ljungman, P. (2007) Respiratory virus infections in bone marrow transplant recipients: the European perspective. The American Journal of Medicine, 102, 44-47.
65. Ljungman, P., Griffiths, P. and Paya, C. (2002) Definitions of cytomegalovirus infection and disease in transplant recipients. Clinical Infectious Diseases, 34, 1094-1097.
66. Loens, K., Ieven, M., Ursi, D. et al. (2003) Improved detection of rhinoviruses by nucleic acid sequence-based amplification after nucleotide sequence determination of the 5_sup_0_/sup_ noncoding regions of additional rhinovirus strains. Journal of Clinical Microbiology, 41, 1971-1976.
67. Loens, K., Goossens, H., De Laat, C. et al. (2006) Detection of rhinoviruses by tissue culture and two independent amplification techniques, nucleic acid sequence-based amplification and reverse transcription-PCR, in children with acute respiratory infections during a winter season. Journal of Clinical Microbiology, 44, 166-171.
68. Lucas, K.G., Burton, R.L., Zimmerman, S.E. et al. (1998) Semiquantitative Epstein-Barr virus (EBV) polymerase chain reaction for the determination of patients at risk for EBV-induced lymphopro-liferative disease after stem cell transplantation. Blood, 91, 3654-3661.
69. Maertens, J., Deeren, D., Dierickx, D. and Theunissen, K. (2006) Pre-emptive antifungal therapy: still a way to go. Current Opinion in Infectious Diseases, 19, 551-556.
70. Malcolm, E., Arruda, E., Hayden, F.G. and Kaiser, L. (2001) Clinical features of patients with acute respiratory illness and rhinovirus in their bronchoalveolar lavages. Journal of Clinical Virology, 21, 9-16.
71. Manfredi, R., Nanetti, A., Ferri, M. and Chiodo, F. (1997) Bacteremia and respiratory involvement by Alcaligenes xylosoxidans in patients infected with the human immunodeficiency virus. European Journal of Clinical Microbiology & Infectious Diseases, 6, 933-938 Review.
72. Manfredi, R., Nanetti, A., Ferri, M. et al. (1999) Flavobacterium spp. organisms as opportunistic bacterial pathogens during advanced HIV disease. The Journal of Infection, 39, 146-152.
73. Manfredi, R., Nanetti, A., Ferri, M. and Chiodo, F. (2000a) Clinical and microbiological survey of Serratia marcescens infection during HIV disease. European Journal of Clinical Microbiology & Infectious Diseases, 19, 248-253.
74. Manfredi, R., Nanetti, A., Ferri, M. and Chiodo, Fl. (2000b) Pseudomonas spp. complications in patients with HIV disease: an eight-year clinical and microbiological survey. European Journal of Epidemiology, 16, 111-118.
75. Marr, K.A., Laverdiere, M., Gugel, A. and Leisenring, W. (2005) Antifungal therapy decreases sensitivity of the Aspergillus galactomannan enzyme immunoassay. Clinical Infectious Diseases, 40, 1762-1769.
76. Martino, R., Porras, R.P., Rabella, N. et al. (2005) Prospective study of the incidence, clinical features, and outcome of symptomatic upper and lower respiratory tract infections by respiratory viruses in adult recipients of hematopoietic stem cell transplants for hematologic malignancies. Biology of Blood and Marrow Transplantation, 11, 781-796.
77. Marty, F.M. and Rubin, R.H. (2006) The prevention of infection post-transplant: the role of prophylaxis, preemptive and empiric therapy. Transplant International, 19, 2-11.
78. Matulis, M. and High, K.P. (2002) Immune reconstitution after hematopoietic stem-cell transplantation and its influence on respiratory infections. Seminars in Respiratory Infections, 17, 130-139.
79. Mazzulli, T., Drew, L.W., Yen-Lieberman, B. et al. (1999) Multicenter comparison of the digene hybrid capture CMV DNA assay (version 2.0), the pp65 antigenemia assay, and cell culture for detection of cytomegalovirus viremia. Journal of Clinical Microbiology, 37, 958-963.
80. McIntosh, K. (2006) Human bocavirus: Developing evidence for pathogenicity. The Journal of Infectious Diseases, 194, 1197-1199.
81. Miguez-Burbano, M.J., Flores, M., Ashkin, D. et al. (2006) Non-tuberculous mycobacteria disease as a cause of hospitalization in HIV-infected subjects. International Journal ofInfectious Diseases, 10, 47-55.
82. Miller, R. and Huang, L. (2004) Pneumocystis jirovecii infection. Thorax, 59, 731-733.
83. Morris, A., Kingsley, L.A., Groner, G. et al. (2004) Prevalence and clinical predictors of Pneumocystis colonization among HIV-infected men. AIDS (London, England), 18, 793-798.
84. Murray, J.F. (2005) Pulmonary complications of HIV-1 infection among adults living in Sub-Saharan Africa. International Journal of Tuberculosis and Lung Disease, 9, 826-835.
85. Nichols, W.G. (2003) Management of infectious complications in the hematopoietic stem cell transplant recipient. Journal of Intensive Care Medicine, 18, 295-312.
86. Nicod, L.P., Pache, J.C. and Howarth, N. (2001) Fungal infections in transplant recipients. The European Respiratory Journal, 17, 133-140.
87. Nosari, A., Anghilieri, M., Carrafiello, G. et al. (2003) Utility of percutaneous lung biopsy for diagnosing filamentous fungal infections in hematologic malignancies. Haematologica, 88, 1405-1409.
88. Odabasi, Z., Mattiuzzi, G., Estey, E. et al. (2004) Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome. Clinical Infectious Diseases, 39, 199-205.
89. Ordas, J., Boga, J.A., Alvarez-Arguelles, M. et al. (2006) Role of metapneumovirus in viral respiratory infections in young children. Journal of Clinical Microbiology, 44, 2739-2742.
90. Pazos, C., Ponton, J. and Del Palacio, A. (2005) Contribution of (1 → 3)-beta-D-glucan chromogenic assay to diagnosis and therapeutic monitoring of invasive aspergillosis in neutropenic adult patients: a comparison with serial screening for circulating galactomannan. Journal of Clinical Microbiology, 43, 299-305.
91. Razonable, R.R. and Emery, V.C. (2004) Management of CMV infection and disease in transplant patients. Herpes, 11, 77-86.
92. Razonable, R.R. and Paya, C.V. (2003) Herpesvirus infections in transplant recipients: current challenges in the clinical management of cytomegalovirus and Epstein-Barr virus infections. Herpes, 10, 60-65.
93. Razonable, R.R., Brown, R.A., Humar, A. et al. (2005) Herpesvirus infections in solid organ transplant patients at high risk of primary cytomegalovirus disease. The Journal of Infectious Diseases, 192, 1331-1339.
94. Reichenberger, F., Habicht, J., Matt, P. et al. (1999) Diagnostic yield of bronchoscopy in histologically proven invasive aspergillosis. Bone Marrow Transplantation, 24, 1195-1199.
95. Rowe, D.T., Qu, L., Reyes, J., Jabbour, N. et al. (1997) Use of quantitative competitive PCR to measure Epstein-Barr virus genome load in the peripheral blood of pediatric transplant patients with lymphoproliferative disorders. Journal of Clinical Microbiology, 35, 1612-1615.
96. Rubin, R.H. (1996) Prevention of infection in the liver transplant recipient. Liver Transplantation and Surgery, (Suppl 1), 89-98.
97. Ruell, J., Barnes, C., Mutton, K. et al. (2007) Active CMV disease does not always correlate with viral load detection. Bone Marrow Transplantation, 40, 55-61.
98. Sandherr, M., Einsele, H., Hebart, H. et al. (2006) Antiviral prophylaxis in patients with haemato-logical malignancies and solid tumours: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Oncology (DGHO). Annals of Oncology, 17, 1051-1059.
99. Sia, I.G. and Patel, R. (2000) New strategies for prevention and therapy of cytomegalovirus infection and disease in solid-organ transplant recipients. Clinical Microbiology Reviews, 13, 83-121.
100. Steininger, C., Kundi, M., Aberle, S.W. et al. (2002) Effectiveness of reverse transcription-PCR, virus isolation, and enzyme-linked immunosorbent assay for diagnosis of influenza A virus infection in different age groups. Journal of Clinical Microbiology, 40, 2051-2056.
101. Templeton, K.E., Scheltinga, S.A., Beersma, M.F. et al. (2004) Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza A and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3 and 4. Journal of Clinical Microbiology, 42, 1564-1569.
102. Templeton, K.E., Scheltinga, S.A., van den Eeden, W.C. et al. (2005) Improved diagnosis of the etiology of community-acquired pneumonia with real-time polymerase chain reaction. Clinical Infectious Diseases, 41, 345-351.
103. Thorne, L.B., Civalier, C., Booker, J. et al. (2007) Analytic validation of a quantitative real-time PCR assay to measure CMV viral load in whole blood. Diagnostic Molecular Pathology: The American Journal of Surgical Pathology, Part B, 16, 73-80.
104. Tortoli, E., Piersimoni, C., Bartoloni, A. et al. (1997) Mycobacterium malmoense in Italy: the modern Norman invasion? European Journal of Epidemiology, 13, 341-346.
105. Vabret, A., Dina, J., Gouarin, S. et al. (2006) Detection of the new human coronavirus HKU1: a report of 6 cases. Clinical Infectious Diseases, 42, 34-39 Epub 2006 Jan 24.
106. van den Hoogen, B.G., de Jong, J.C., Groen, J. et al. (2001) A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nature Medicine, 7, 719-724.
107. van Elden, L.J., van Loon, A.M., van der Beeck, M. et al. (2003) Applicability of real-time quantitative PCR assay for diagnosis of respiratory syncycial virus infection in immunocompromised patients. Journal of Clinical Microbiology, 41, 5378-7381.
108. van Esser, J.W., Niesters, H.G., Thijsen, S.F. et al. (2001) Molecular quantification of viral load in plasma allows for fast and accurate prediction of response to therapy of Epstein-Barr virus-associated lymphoproliferative disease after allogeneic stem cell transplantation. British Journal of Haematology, 113, 814-821.
109. van Esser, J.W., Niesters, H.G., van der Holt, B. et al. (2002) Prevention of Epstein-Barr virus-lymphoproliferative disease by molecular monitoring and preemptive rituximab in high-risk patients after allogeneic stem cell transplantation. Blood, 99, 4364-4369.
110. Wakefeld, A.E., Pixley, F.J., Banerji, S. et al. (1990) Detection of Pneumocystis carinii with DNA detection. Lancet, 336, 451-453.
111. Wang, J.Y., Chang, Y.L., Lee, L.N. et al. (2004) Diffuse pulmonary infiltrates after bone marrow transplantation: the role of open lung biopsy. The Annals of Thoracic Surgery, 78, 267-272 Review.
112. Wheat, L.J. (2003) Rapid diagnosis of invasive aspergillosis by antigen detection. Transplant Infectious Disease, 5, 158-166.
113. Wheat, L.J., Goldman, M. and Sarosi, G. (2002) State-of-the-art review of pulmonary fungal infections. Seminars in Respiratory Infections, 17, 158-181.
114. Whimbey, E. and Bodey, G.P. (1992) Viral pneumonia in the immunocompromised adult with neoplastic disease: the role of common community respiratory viruses. Seminars in Respiratory Infections, 7, 122-131.
115. Whimbey, E., Englund, J.A. and Couch, R.B. (1997) Community respiratory virus infections in immunocompromised patients with cancer. The American Journal of Medicine, 102, 10-18.
116. Zamora, M.R. (2004) Cytomegalovirus and lung transplantation. American Journal of Transplantation, 8, 1219-1226.