In vivo skin chromophore mapping using a multimode imaging dermoscope (SkinSpec™)

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 8587, Issue , 2013, Pages

  MacKinnon, Nicholas ^a   Vasefi, Fartash ^a   Gussakovsky, Eugene ^a   Bearman, Gregory ^a   Chave, Robert ^a   Farkas, Daniel L ^a,b  

^a Spectral Molecular Imaging Inc   (United States)

^b University of Southern California   (United States)

Author keywords

autofluorescence; hyperspectral imaging; melanoma; multimode dermoscope; polarization; skin cancer

Indexed keywords

AUTOFLUORESCENCE; HYPERSPECTRAL IMAGING; MELANOMA; MULTIMODES; SKIN CANCERS;

BIOMOLECULES; DERMATOLOGY; HEMOGLOBIN; HISTOLOGY; MELANIN; ONCOLOGY; POLARIZATION; SPECTROSCOPY; SURFACE RECONSTRUCTION; TISSUE;

CHROMOPHORES;

EID: 84877996151     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.2005587     Document Type: Conference Paper

References (42)

1. Alexandrescu, D., "Melanoma costs: a dynamic model comparing estimated overall costs of various clinical stages," Dermatol Online J, 15(11), 1 (2009).
2. American Cancer Society. (2011). Melanoma Skin Cancer Overview. http://www.cancer.org (last access: January 2013).
3. SEER Cancer Statistics Review. http://seer.cancer.gov (last access: January 2013).
4. SEER Stat Fact Sheets: Melanoma of the Skin. http://seer.cancer.gov (last access: January 2013).
5. Costs of Cancer Care report from NCI. http://progressreport.cancer.gov (last access: January 2013).
6. Farkas, D.L., "Invention and commercialization in Optical Bioimaging," Nature Biotechnology, 21, 1269-1271 (2003).
7. Benelli, C., Roscetti, E., Dal Pozzo, V., Gasparini, G., and Cavicchini, S., "The dermoscopic versus the clinical diagnosis of melanoma," Eur J Dermatol 9(6), 470-476 (1999).
8. McGovern, T. W. and Litaker, M. S., "Clinical predictors of malignant pigmented lesions. A comparison of the Glasgow seven-point checklist and the American Cancer Society's ABCDs of pigmented lesions," J Dermatol Surg Oncol, 18(1), 22-26 (1992).
9. Thomas, L, Tranchand, P., Berard, F., Secchi, T., Colin, C. and Moulin, G., "Semiological value of ABCDE criteria in the diagnosis of cutaneous pigmented tumors," Dermatology, 197(1), 11-17 (1998).
10. Du Vivier, A. W., Williams, H. C., Brett, J.V. and Higgins, E.M., "How do malignant melanomas present and does this correlate with the seven-point checklist?," Clin Exp Dermatol,16(5), 344-347 (1991).
11. Higgins, E. M., Hall, P., Todd, P., Murthi, R. and Du Vivier, A.W., "The application of the seven-point check-list in the assessment of benign pigmented lesions," Clin Exp Dermatol, 17(5), 313-315 (1992).
12. Melanoma Research Foundation. http://www.melanoma.org (last access: January 2013).
13. Jones, T.P., Boiko, P.E. and Piepkorn, M.W., "Skin biopsy indications in primary care practice: a population-based study," J Am Board Farm Pract, 9(6), 397-404 (1996).
14. Bafounta, M.L., Beauchet, A., Aegerter, P. and Saiag, P., "Is dermoscopy (epiluminescence microscopy) useful for the diagnosis of melanoma? Results of a meta-analysis using techniques adapted to the evaluation of diagnostic tests," Arch Dermatol, 137(10), 1343-50 (2001).
15. Massone, C., Di Stefani, A. and Soyer, H. P., "Dermoscopy for skin cancer detection," Curr Opin Oncol., 17(2), 147-153 (2005).
16. Moncrieff, M., Cotton, S., Claridge, E. and Hall, P., "Spectrophotometric intracutaneous analysis: a new technique for imaging pigmented skin lesions," Br J Dermatol, 146(3), 448-57 (2002).
17. Gutkowicz-Krusin, D., Elbaum, M., Jacobs, A., Keem, S., Kopf, A.W., Kamino, H., Wang, S., Rubin, P., Rabinovitz, H. and Oliviero, M., "Precision of automatic measurements of pigmented skin lesion parameters with a MelaFind™ multispectral digital dermoscope," Melanoma Res, 10(6), 563-70 (2000).
18. Lui, H., Zhao, J., McLean, D. and Zeng, H., "Real-time Raman spectroscopy for in vivo skin cancer diagnosis," Cancer Res, 72(10), 2491-500 (2012).
19. Bergstrom, K.G., "MelaFind was approved by FDA. Where does it fit in dermatology?," J Drugs Dermatol, 11(3), 420-422 (2012).
20. Altman E., MelaFind, an FDA-approved device for melanoma detection: Pros and Cons http://boards.medscape.com (2011)
21. Elbaum, M., Kopf, A.W., Rabinovitz, H.S., Langley, R.G., Kamino, H., Mihm, M.C.Jr. Sober, A.J., Peck, G.L., Bogdan, A., Gutkowicz-Krusin, D., Greenebaum, M., Keem, S., Oliviero, M. and Wang, S., "Automatic differentiation of melanoma from melanocytic nevi with multispectral digital dermoscopy: a feasibility study," J Am Acad Dermatol, 44(2), 207-18 (2001).
22. Zhao, J., Lui, H., McLean, D.I. and Zeng, H., "Real-time Raman spectroscopy for non-invasive skin cancer detection - preliminary results," Conf Proc IEEE Eng Med Biol Soc, 3107-3109 (2008).
23. Nishidate I, Tanaka N, Kawase T, et al; "Noninvasive imaging of human skin hemodynamics using a digital red-green-blue camera." J. Biomed. Opt., 16(8), 086012-086012-14 (2011).
24. Kirkwood, J.M., Farkas, D.L., et al. "Systemic interferon-treatment leads to Stat3 inactivation in melanoma precursor lesions." Molecular Medicine, 5, 11-20 (1999).
25. Yang, P., Farkas, D.L., et al. "Macroscopic spectral imaging and gene expression analysis of the early stages of melanoma." Molecular Medicine, 5, 785-794.
26. Farkas, D.L. and Becker, D. "Applications of spectral imaging: detection and analysis of human melanoma and its precursors." Pigment Cell Research, 14, 2-8 (2001).
27. Valesky, M., Spang, A.J., Fisher, G.W., Farkas, D.L. and Becker, D. "Non-invasive, dynamic fluorescence imaging of human melanomas reveals that targeted inhibition of bFGF and FGFR-1 blocks tumor growth by inducing melanoma cell apoptosis." Molecular Medicine, 8, 103-112 (2002).
28. Pfaff-Smith, A., Kirkwood, J.M., Edington, H.D., Jukic, D.M., Farkas, D.L. and Becker, D. "Fluorescence imaging analysis of upstream regulators and downstream targets of STAT3 in melanoma precursor lesions obtained from patients before and after systemic low-dose interferon-a treatment." Molecular Imaging, 2, 65-73 (2003).
29. Farkas, D.L., Baxter, G., DeBiasio, R., Gough, A., Nederlof, M.A., Pane, D., Pane, J., Patek, D.R., Ryan, K.W., Taylor, D.L., "Multimode light microscopy and the dynamics of molecules, cells and tissues," Annual Review of Physiology, 55, 785-817 (1993).
30. Taylor, D.L, DeBiasio, R., LaRocca, G., Pane, D., Post, P., Kolega, J., Giuliano, K., Burton, K., Gough, A., Dow, A., Yu, H., Waggoner, A.S., and Farkas, D.L., "Potential of machine-vision light microscopy in toxicologic pathology," Toxicologic Pathology, 22, 145-159 (1994).
31. Hwang, J.Y., Wachsmann-Hogiu, S., Ramanujan, V.K., Ljubimova, J., Gross, Z., Gray, H.B., Medina-Kauwe, L.K., Farkas, D.L., "A multimode optical imaging system for preclinical applications in vivo: Technology development, multi-scale imaging and chemotherapy assessment," Molecular Imaging and Biology, 14, 431-442 (2011)
32. Klier, K., "Absorption and Scattering in Plane Parallel Turbid Media," J. Opt. Soc. Am. 62, 882-885 (1972)
33. Prahl, S., "Tabulated Molar Extinction Coefficient for Hemoglobin in Water," http://omlc.ogi.edu/spectra/hemoglobin/summary.html (last access: January 2013).
34. Jacques, S.L., "Extinction coefficient of melanin," http://omlc.ogi.edu/spectra/melanin/eumelanin.html (last access: January 2013).
35. Simpson, C. R., Kohl, M., Essenpreis, M. and Cope, M, "Near infrared optical properties ofex-vivo human skin and subcutaneous tissues measured using the Monte Carlo inversion technique," Phys Med Biol, 43, 2465-2478 (1998).
36. Laufer, J., Simpson, C. R., Kohl, M., Essenpreis, M. and Cope, M., "Effect of temperature on the optical properties of ex-vivo human dermis," Phys Med Biol 43, 2479-2489 (1998).
37. Kuzmina, I., Diebele, I., Jakovels, D., Spigulis, J., Valeine, L., Kapostinsh, J., and Berzina, A., "Towards noncontact skin melanoma selection by multispectral imaging analysis," J. Biomed. Opt., 16(6), 060502-060502-3 (2011).
38. Yu. L., Joseph, A.O.N.R., Lindsley, E.H. and Farkas, D.L., "Polarization-sensitive digital dermoscopy for image processing-assisted evaluation of atypical nevi: Towards step-wise detection of melanoma," Progress in Biomedical Optics and Imaging, 7902, 0K 1-6 (2011).
39. Jacques, S.L., Ramella-Roman, J.C., Lee, K., "Imaging skin pathology with polarized light," J. Biomed. Opt. 7(3), 329-340 (2002).
40. Jacques, S. L., Roman, J. R., and Lee, K., "Imaging superficial tissues with polarized light," Lasers in Surgery and Medicine, 26(2), 119-129 (2000).
41. Jacques, S. L., Samatham, R., Isenhath, S., and Lee, K., "Polarized light camera to guide surgical excision of skin cancers," Proc. SPIE., 6842, 68420I (2008).
42. 2) monitoring with the Edwards Swan-Ganz oximetry TD System," http://ht.edwards.com/resourcegallery/products/swanganz/pdfs/ svo2edbook.pdf (last access: January 2013)