Neonatal CSF oxytocin levels are associated with parent report of infant soothability and sociability

Psychoneuroendocrinology

Volumn 38, Issue 7, 2013, Pages 1208-1212

  Clark, Catherine L ^a   St John, Nicholas ^b   Pasca, Anca M ^a   Hyde, Shellie A ^a   Hornbeak, Kirsten ^a   Abramova, Marina ^a   Feldman, Heidi ^a   Parker, Karen J ^a   Penn, Anna A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LUCILE PACKARD CHILDREN S HOSPITAL   (United States)

Author keywords

CSF; Newborn; Oxytocin; Social behavior; Social engagement; Soothability

Indexed keywords

BIOLOGICAL MARKER; OXYTOCIN;

AGE DISTRIBUTION; ARTICLE; CEREBROSPINAL FLUID LEVEL; CHILD BEHAVIOR; CLINICAL EVALUATION; CRYING; FEMALE; GESTATIONAL AGE; HORMONE ACTION; HORMONE DETERMINATION; HUMAN; INFANT; LONGITUDINAL STUDY; LUMBAR PUNCTURE; MALE; NEWBORN; OXYTOCIN CEREBROSPINAL FLUID LEVEL; PERINATAL PERIOD; PILOT STUDY; PRIORITY JOURNAL; SOCIAL BEHAVIOR; SOCIAL INTERACTION;

FEMALE; HUMANS; INFANT; INFANT BEHAVIOR; INFANT, NEWBORN; LONGITUDINAL STUDIES; MALE; OBJECT ATTACHMENT; OXYTOCIN; PARENT-CHILD RELATIONS; PARENTS; SOCIAL BEHAVIOR; TEMPERAMENT;

EID: 84877924752     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2012.10.017     Document Type: Article

References (16)

1. Amico J.A., Challinor S.M., Cameron J.L. Pattern of oxytocin concentrations in the plasma and cerebrospinal fluid of lactating rhesus monkeys (Macaca mulatta): evidence for functionally independent oxytocinergic pathways in primates. J. Clin. Endocrinol. Metab. 1990, 71:1531-1535.
2. Amico J.A., Tenicela R., Johnston J., Robinson A.G. A time-dependent peak of oxytocin exists in cerebrospinal fluid but not in plasma ofhumans. J. Clin. Endocrinol. Metab. 1983, 57:947-951.
3. Carter C.S. Sex differences in oxytocin and vasopressin: implications for autism spectrum disorders?. Behav. Brain Res. 2007, 176:170-186.
4. Heim C., Young L.J., Newport D.J., Mletzko T., Miller A.H., Nemeroff C.B. Lower CSF oxytocin concentrations in women with a history of childhood abuse. Mol. Psychiatry 2009, 14:954-958.
5. Higashida H., Yokoyama S., Kikuchi M., Munesue T. CD38 and its role in oxytocin secretion and social behavior. Horm. Behav. 2012, 61:351-358.
6. Insel T.R. The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior. Neuron 2010, 65:768-779.
7. Jokinen J., Chatzittofis A., Hellstrom C., Nordstrom P., Uvnas-Moberg K., Asberg M. Low CSF oxytocin reflects high intent in suicide attempters. Psychoneuroendocrinology 2012, 37:482-490.
8. Meyer-Lindenberg A., Domes G., Kirsch P., Heinrichs M. Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat. Rev. Neurosci. 2011, 12:524-538.
9. Modahl C., Green L., Fein D., Morris M., Waterhouse L., Feinstein C., Levin H. Plasma oxytocin levels in autistic children. Biol. Psychiatry 1998, 43:270-277.
10. Modi M.E., Young L.J. The oxytocin system in drug discovery for autism: animal models and novel therapeutic strategies. Horm. Behav. 2012, 61:340-350.
11. Parker K.J., Hoffman C.L., Hyde S.A., Cummings C.S., Maestripieri D. Effects of age on cerebrospinal fluid oxytocin levels in free-ranging adult female and infant rhesus macaques. Behav. Neurosci. 2010, 124:428-433.
12. Rosenblum L.A., Smith E.L., Altemus M., Scharf B.A., Owens M.J., Nemeroff C.B., Gorman J.M., Coplan J.D. Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques. Psychoneuroendocrinology 2002, 27:651-660.
13. Rothbart M.K. Measurement of temperament in infancy. Child Dev. 1981, 52:569-578.
14. Sparrow S.S., Cicchetti D.V., Balla D.A. Vineland Adaptive Behavior Scales 2005, American Guidance Service, Circle Pines, MN. 2nd edition.
15. Veening J.G., Barendregt H.P. The regulation of brain states by neuroactive substances distributed via the cerebrospinal fluid: a review. Cerebrospinal Fluid Res. 2010, 7:1.
16. Winslow J.T., Noble P.L., Lyons C.K., Sterk S.M., Insel T.R. Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys. Neuropsychopharmacology 2003, 28:910-918.