Gardnerella vaginalis: Still a prime suspect in the pathogenesis of bacterial vaginosis

Current Infectious Disease Reports

Volumn 15, Issue 2, 2013, Pages 130-135

  Muzny, C A ^a   Schwebke, J R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Bacterial vaginosis; Biofilm; Gardnerella vaginalis; Polymicrobial

Indexed keywords

ARTICLE; ATOPOBIUM VAGINAE; BIOFILM; GARDNERELLA VAGINALIS; HUMAN; INFECTION RISK; LACTOBACILLUS; MIXED INFECTION; NUGENT SCORE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PREVALENCE; SCORING SYSTEM; SEXUAL BEHAVIOR; SEXUALLY TRANSMITTED DISEASE; VAGINITIS;

EID: 84877920156     PISSN: 15233847     EISSN: 15343146     Source Type: Journal    
DOI: 10.1007/s11908-013-0318-4     Document Type: Article

References (45)

1. Sobel JD. Bacterial vaginosis. Annu Rev Med. 2000;51:349-56.
2. Schwebke J. Gynecologic consequences of bacterial vaginosis. Obstet Gynecol Clin North Am. 2003;30:685-94.
3. Hillier SL. Diagnostic microbiology of bacterial vaginosis. Am J Obstet Gynecol. 1993;169:455-9.
4. Amsel R, Totten PA, Spiegel CA, Chen KCS, Eschenbach D, Holmes KK. Non-specific vaginitis: diagnostic and microbial and epidemiological associations. Am J Med. 1983;74:14-22.
5. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of Gram stain interpretation. J Clin Microbiol. 1991;29:297-301.
6. Workowski KA, Berman S, Centers for Disease Control and Prevention (CDC). Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep. 2010;59(RR-12):1-110. This is the current CDC treatment guidelines for STD treatment.
7. Hillier SL, Krohn MA, Rabe LK, Klebanoff SJ, Eschenbach DA. The normal vaginal flora, H2O2-producing lactobacilli and bacterial vaginosis in pregnant women. Clin Infect Dis. 1993;16(S4):S273-81.
8. Sobel J, Ferris D, Schwebke J, Nyirjesy P, Wiesenfeld HC, Peipert J, et al. Suppressive maintenance antibacterial therapy with 0.75 % metronidazole vaginal gel to prevent recurrent bacterial vaginosis. Am J Obstet Gynecol. 2006;194:1283-9.
9. Bradshaw CS, Morton AN, Hocking J, Garland SM, Morris MB, Moss LM, et al. High recurrence rates of bacterial vaginosis over 12 months following oral metronidazole and factors associated with recurrence. J Infect Dis. 2006;193:1478-86. An excellent study of the factors associated with recurrent BV.
10. Hawes SE, Hillier SL, Benedetti J, Stevens CE, Koutsky LA, Wolner-Hanssen P, et al. Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections. J Infect Dis. 1996;174:1058-63.
11. Schwebke J, Desmond RA. Risk factors for bacterial vaginosis in women at high risk for STDs. Sex Transm Dis. 2005;32:654-8.
12. Gardner HL, Dukes CD. Haemophilus vaginalis vaginitis. A newly defined specific infection previously classified "nonspecific vaginitis". Am J Obstet Gynecol. 1955;69:962-76.
13. Holst E. Reservoir of four organisms associated with bacterial vaginosis suggests lack of sexual transmission. J Clin Microbiol. 1990;28:2035-9.
14. Hillier SL, Rabe LK, Muller CH, Zarutskie P, Kuzan FB, Stenchever MA. Relationship of bacteriologic characteristics to semen indices in men attending an infertility clinic. Obstet Gynecol. 1990;75:800-4.
15. Bump RC, Buesching WJ. Bacterial vaginosis in virginal and sexually active adolescent females: evidence against exclusive sexual transmission. Am J Obstet Gynecol. 1988;158:935-9.
16. Fethers K, Fairley CK, Morton A, Hocking JS, Hopkins C, Kennedy LJ, et al. Early sexual experiences and risk factors for bacterial vaginosis. J Infect Dis. 2009;200:1662-70. A study of BV and sexual behavior in college-aged women.
17. Sanchez S, Garcia PJ, Thomas KK, Catlin M, Holmes KK. Intravaginal metronidazole gel versus metronidazole plus nystatin ovules for bacterial vaginosis: a randomized controlled trial. Am J Obstet Gynecol. 2004;191:1898-906.
18. Schwebke JR, Desmond RA. A randomized trial of metronidazole duration plus or minus azithromycin for treatment of symptomatic bacterial vaginosis. Clin Infect Dis. 2007;44:213-9.
19. Hutchinson K, Kip KE, Ness RB. Condom use and its association with bacterial vaginosis and bacterial vaginosis-associated vaginal microflora. Epidemiology. 2007;18:702-8.
20. Koumans EH, Sternberg M, Bruce C, McQuillan G, Kendrick J, Sutton M, et al. The prevalence of bacterial vaginosis in the United States, 2001-2004; Associations with symptoms, sexual behaviors, and reproductive health. Sex Transm Dis. 2007;34:864-9.
21. Marrazzo J, Koutsky L, Eschenbach D, Agnew K, Stine K, Hillier S. Characterization of vaginal flora and bacterial vaginosis in women who have sex with women. J Infect Dis. 2002;185:1307-13.
22. Marrazzo J, Thomas KK, Fiedler T, Ringwood K, Fredricks D. Risks for acquisition of bacterial vaginosis among women who report sex with women: a cohort study. PLoS One. 2010;5:e11139. Important study of risk factors for BV in women who have sex with women.
23. Marrazzo J, Thomas KK, Agnew K, Stine K, Hillier SL. Prevalence and risks for bacterial vaginosis in women who have sex with women. Sex Transm Dis. 2010;37:335-9.
24. Marrazzo J, Fiedler T, Srinivasin S, Thomas KK, Liu C, Ko D, Xie, et al. Extravaginal reservoirs of vaginal bacterial risk factors for incident bacterial vaginosis. J Infect Dis. 2012;205:1580-8.
25. Swidsinski A, Mendling W, Loening-Baucke V, Ladhoff A, Swidsinski S, Hale LP, et al. Adherent biofilms in bacterial vaginosis. Obstet Gynecol. 2005;106:1013-23. Sentinel paper on biofilm in BV.
26. Srinavasin S, Fredricks D. The human vaginal bacterial biota and bacterial vaginosis. Interdiscip Perspect Infect Dis. 2008;2008:750479.
27. Fredricks D, Fiedler BS, Marrazzo JM. Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med. 2005;353:1899-911. Comprehensive study of noncultivatable bacteria associated with BV.
28. Ruby J, Goldner M. Nature of symbiosis in oral disease. J Dent Res. 2007;86:8-11.
29. Swidsinski A, Doerffel Y, Loening-Baucke V, Swidsinski S, Verstraelen H, Vaneechoutte M, et al. Gardnerella biofilm involves females and males and is sexually transmitted. Gynecol Obstet Invest. 2010;70:256-63. Interesting study of the sexual transmission of BV.
30. Hill GB. The microbiology of bacterial vaginosis. Am J Obstet Gynecol. 1993;169:450-4.
31. Criswell BS, Ladwig CL, Gardner HL, Dukes CD. Haemophilus vaginalis: vaginitis by inoculation from culture. Obstet Gynecol. 1969;33:195-9.
32. Patterson JL, Stull-Lane A, Girerd PH, Jefferson KK. Analysis of adherence, biofilm formation and cytotoxicity suggests a greater virulence potential of Gardnerella vaginalis relative to other bacterial-vaginosis- associated anaerobes. Microbiology. 2010;156:392-9. Study of the virulence factors of Gardnerella.
33. Piot P, Van Dyck E, Peeters M, Hale J, Totten PA, Holmes KK. Biotypes of Gardnerella vaginalis. J Clin Microbiol. 1984;20:677-9.
34. Briselden AM, Hillier SL. Longitudinal study of the biotypes of Gardnerella vaginalis. J Clin Microbiol. 1990;28:2761-4.
35. Hedges S, Barrientes F, Desmond RA, Schwebke JR. Local and systemic cytokine levels in relation to changes in vaginal flora. J Infect Dis. 2006;193:556-62.
36. Brotman RM, Klebanoff MA, Nansel TR, Yu KF, Andrews WW, Zhang J, et al. Bacterial vaginosis assessed by gram stain and diminished colonization resistance to incident gonococcal, chlamydial, and trichomonal genital infection. J Infect Dis. 2010;202:1907-15. Important data on the association between BV and acquisition of STD.
37. Vejtorp M, Bollerup AC, Vejtorp L, Fanøe E, Nathan E, Reiter A, et al. Bacterial vaginosis: a double-blind randomized trial of the effect of treatment of the sexual partner. Br J Obstet Gynaecol. 1988;95:920-6.
38. Mengel MB, Berg AO, Weaver CH, Herman DJ, Herman SJ, Hughes VL, et al. The effectiveness of single-dose metronidazole therapy for patients and their partners with bacterial vaginosis. J Fam Pract. 1989;28:163-71.
39. Swedberg J, Steiner JF, Deiss F, Steiner S, Driggers DA. Comparison of single-dose vs. one-week course of metronidazole for symptomatic bacterial vaginosis. JAMA. 1985;254:1046-9.
40. Mehta S. Systematic review of randomized trials of treatment of male sexual partners for improved bacterial vaginosis outcomes in women. Sex Transm Dis. 2012;39:822-30. Nice review of the published studies of treatment of the male partner to prevent recurrent BV.
41. Fethers K, Twin J, Fairley CK, Fowkes FJ, Garland SM, Fehler G, et al. Bacterial vaginosis (BV) candidate bacteria: associations with BV and behavioural practices in sexually-experienced and inexperienced women. PLoS One. 2012;7:e30633.
42. Totten PA, Amsel R, Hale J, Piot P, Holmes KK. Selective differential human blood bilayer media for isolation of Gardnerella (Haemophilus) vaginalis. J Clin Microbiol. 1982;15:141-7.
43. Fredricks DN, Fiedler TL, Thomas KK, Oakley BB, Marrazzo JM. Targeted PCR for detection of vaginal bacteria associated with bacterial vaginosis. J Clin Microbiol. 2007;45:3270-6.
44. Thies F, Konig W, Konig B. Rapid characterization of the normal and disturbed vaginal microbiota by application of 16S rRNA gene terminal RFLP fingerprinting. J Med Microbiol. 2007;56:755-61.
45. Schwebke J, Richey C, Weiss H. Correlation of behaviors with microbiological changes in vaginal flora. J Infect Dis. 1999;180:1632-6.