Solubility and stability of indomethacin in arginine-assisted solubilization system

Pharmaceutical Development and Technology

Volumn 18, Issue 4, 2013, Pages 852-855

  Qi, Xiaodan ^a   Zhang, Jing ^a   Wang, Wei ^a   Cao, Deying ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Arginine; Hydrotrope; Indomethacin; Solubility; Stability

Indexed keywords

ARGININE; INDOMETACIN;

AQUEOUS SOLUTION; ARTICLE; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; FREEZE DRYING; PRIORITY JOURNAL; SHELF LIFE; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARGININE; DRUG STABILITY; DRUG STORAGE; FREEZE DRYING; INDOMETHACIN; PHARMACEUTICAL SOLUTIONS; POWDERS; SOLUBILITY;

EID: 84877846794     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2011.595797     Document Type: Article

References (20)

1. Hammerman C, Kaplan M. Comparative tolerability of pharmacological treatments for patent ductus arteriosus. Drug Saf 2001;24:537-551.
2. Rubino CM, Shaffer CL, Gal P, Ransom JL, Kissling GE. Postnatal pharmacologic prevention of intraventricular hemorrhage: meta-analysis of phenobarbital and indomethacin. Pediatr Nurs 1997;23:196-204.
3. Miyako Y, Khalef N, Matsuzaki K, Pinal R. Solubility enhancement of hydrophobic compounds by cosolvents: role of solute hydrophobicity on the solubilization effect. Int J Pharm 2010;393:48-54.
4. Kawakami K, Miyoshi K, Ida Y. Solubilization behavior of poorly soluble drugs with combined use of Gelucire 44/14 and cosolvent. J Pharm Sci 2004;93:1471-1479.
5. Jain AK. Solubilization of indomethacin using hydrotropes for aqueous injection. Eur J Pharm Biopharm 2008;68:701-714.
6. Okore VC. Solubility and stability of indomethacin in sodium acetate solution. A consideration of hydrotropic mechanism. Boll Chim Farm 1997;136:680-684.
7. Lin SY, Kawashima Y. Kinetic studies on the stability of indomethacin in alkaline aqueous solution containing poly(oxyethylene) poly(oxypropylene) surface-active block copolymers. Pharm Acta Helv 1985;60:345-350.
8. Jansook P, Kurkov SV, Loftsson T. Cyclodextrins as solubilizers: formation of complex aggregates. J Pharm Sci 2010;99:719-729.
9. Salústio PJ, Feio G, Figueirinhas JL, Pinto JF, Cabral Marques HM. The influence of the preparation methods on the inclusion of model drugs in a beta-cyclodextrin cavity. Eur J Pharm Biopharm 2009;71:377-386.
10. Dimitrova E, Bogdanova S, Mitcheva M, Tanev I, Minkov E. Development of model aqueous ophthalmic solution of indomethacin. Drug Dev Ind Pharm 2000;26:1297-1301.
11. Hirano A, Kameda T, Arakawa T, Shiraki K. Arginine-assisted solubilization system for drug substances: solubility experiment and simulation. J Phys Chem B 2010;114:13455-13462.
12. Arakawa T, Kita Y, Koyama AH. Solubility enhancement of gluten and organic compounds by arginine. Int J Pharm 2008;355: 220-223.
13. Kato A, Maki K, Ebina T, Kuwajima K, Soda K, Kuroda Y. Mutational analysis of protein solubility enhancement using short peptide tags. Biopolymers 2007;85:12-18.
14. Singhai AK, Jain S, Jain NK. Stability studies on aqueous injection of ketoprofen. Pharmazie 1997;52:226-228.
15. Agrawal S, Pancholi SS, Jain NK, Agrawal GP. Hydrotropic solubilization of nimesulide for parenteral administration. Int J Pharm 2004;274:149-155.
16. Mura P, Maestrelli F, Cirri M. Ternary systems of naproxen with hydroxypropyl-beta-cyclodextrin and aminoacids. Int J Pharm 2003;260:293-302.
17. Mura P, Bettinetti GP, Cirri M, Maestrelli F, Sorrenti M, Catenacci L. Solid-state characterization and dissolution properties of naproxen-arginine- hydroxypropyl-beta-cyclodextrin ternary system. Eur J Pharm Biopharm 2005;59:99-106.
18. Das U, Hariprasad G, Ethayathulla AS, Manral P, Das TK, Pasha S et al. Inhibition of protein aggregation: supramolecular assemblies of arginine hold the key. PLoS ONE 2007;2:e1176.
19. Ain-Ai A, Gupta PK. Effect of arginine hydrochloride and hydroxypropyl cellulose as stabilizers on the physical stability of high drug loading nanosuspensions of a poorly soluble compound. Int J Pharm 2008;351:282-288.
20. Hirano A, Arakawa T, Shiraki K. Arginine increases the solubility of coumarin: comparison with salting-in and salting-out additives. J Biochem 2008;144:363-369.