Impact of meropenem in combination with tobramycin in a murine model of pseudomonas aeruginosa pneumonia

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 6, 2013, Pages 2788-2792

  Louie, Arnold ^a   Liu, Weiguo ^a   Fikes, Steven ^a   Brown, David ^a   Drusano, G L ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; MEROPENEM; TOBRAMYCIN;

ANIMAL MODEL; ARTICLE; BACTERIAL LOAD; COLONY FORMING UNIT; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; EPITHELIUM; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS PNEUMONIA;

ANIMALS; ANTI-BACTERIAL AGENTS; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; LUNG; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, THEORETICAL; PNEUMONIA, BACTERIAL; PSEUDOMONAS AERUGINOSA; THIENAMYCINS; TOBRAMYCIN; TREATMENT OUTCOME;

EID: 84877844463     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02624-12     Document Type: Article

References (14)

1. Drusano GL, Lodise TP, Melnick D, Liu W, Oliver A, Mena A, Van Scoy B, Louie A. 2011. Meropenem penetration into epithelial lining fluid in mice and men and delineation of exposure targets. Antimicrob. Agents Chemother. 55:3406-3412.
2. Lodise TP, Sörgel F, Mason B, Melnick D, Kinzig M, Drusano GL. 2011. Penetration of meropenem into epithelial lining fluid in intubated patients with nosocomial pneumonia. Antimicrob. Agents Chemother. 55: 1606-1610.
3. Drusano GL, Liu W, Fregeau C, Kulawy R, Louie A. 2009. Differing effects of combination chemotherapy with meropenem and tobramycin on cell kill and suppression of resistance on wild-type Pseudomonas aeruginosa PAO1 and its isogenic MexAB efflux pump-overexpressed mutant. Antimicrob. Agents Chemother. 53:2266-2273.
4. Louie A, Fregeau C, Liu W, Kulawy R, Drusano GL. 2009. Pharmacodynamics of levofloxacin in a murine pneumonia model of Pseudomonas aeruginosa infection: Determination of epithelial lining fluid targets. Antimicrob. Agents Chemother. 53:3325-3330.
5. Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: Approved standard. CLSI publication M7-A7. Clinical and Laboratory Standards Institute, Wayne, PA.
6. Leary R, Jelliffe R, Schumitzky A, Van Guilder M. 2001. An adaptive grid non-parametric approach to pharmacokinetic and dynamic (PK/PD) models, p 389-394. Proceedings of the 14th IEEE Symposium on Computer-Based Medical Systems. IEEE Computer Society, Bethesda, MD.
7. D'Argenio DZ, Schumitzky A, Wang X. 2009. ADAPT 5 user's guide: Pharmacokinetic/pharmacodynamic systems analysis software. Biomedical Simulations Resource, Los Angeles, CA.
8. Greco WR, Bravo G, Parsons JC. 1995. The search for synergy: A critical review from a response surface perspective. Pharmacol. Rev. 47:331-385.
9. Chastre J, Wolff M, Fagon JY, Chevret S, Thomas F, Wermert D, Clementi E, Gonzalez J, Jusserand D, Asfar P, Perrin D, Fieux F, Aubas S, PneumA Trial Group. 2003. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: A randomized trial. JAMA 290:2588-2598.
10. Fink MP, Snydman DR, Niederman MS, Leeper KV, Jr, Johnson RH, Heard SO, Wunderink RG, Caldwell JW, Schentag JJ, Siami GA, The Severe Pneumonia Study Group. 1994. Treatment of severe pneumonia in hospitalized patients: Results of a multicenter, randomized, doubleblind trial comparing intravenous ciprofloxacin with imipenemcilastatin. Antimicrob. Agents Chemother. 38:547-557.
11. Drusano GL, Fregeau C, Liu W, Brown DL, Louie A. 2010. Impact of burden on granulocyte clearance of bacteria in a mouse thigh infection model. Antimicrob. Agents Chemother. 54:4368-4372.
12. Drusano GL, Vanscoy B, Liu W, Fikes S, Brown D, Louie A. 2011. Saturability of granulocyte kill of Pseudomonas aeruginosa in a murine model of pneumonia. Antimicrob. Agents Chemother. 55:2693-2695.
13. Jumbe N, Louie A, Leary R, Liu W, Deziel MR, Tam VH, Bachhawat R, Freeman C, Kahn JB, Bush K, Dudley MN, Miller MH, Drusano GL. 2003. Application of a mathematical model to prevent in-vivo amplification of antibiotic-resistant bacterial populations during therapy. J. Clin. Invest. 112:275-285.
14. White DB, Slocum HK, Brun Y, Wrzosek C, Greco WR. 2003. A new nonlinear mixture response surface paradigm for the study of synergism: A three drug example. Curr. Drug Metab. 4:399-409.