메뉴 건너뛰기




Volumn 190, Issue 10, 2013, Pages 5329-5336

G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 BROMOPHENYL) 3 (2 HYDROXY 4 NITROPHENYL)UREA; BETA ARRESTIN 2; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; G PROTEIN COUPLED RECEPTOR KINASE 6; GELATINASE A; GELATINASE B; STROMAL CELL DERIVED FACTOR 1; VASCULOTROPIN;

EID: 84877836566     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202058     Document Type: Article
Times cited : (37)

References (48)
  • 1
    • 33845412884 scopus 로고    scopus 로고
    • GRKs and arrestins: Regulators of migration and inflammation
    • DOI 10.1189/jlb.0606373
    • Vroon, A., C. J. Heijnen, and A. Kavelaars. 2006. GRKs and arrestins: regulators of migration and inflammation. J. Leukoc. Biol. 80: 1214-1221. (Pubitemid 44904958)
    • (2006) Journal of Leukocyte Biology , vol.80 , Issue.6 , pp. 1214-1221
    • Vroon, A.1    Heijnen, C.J.2    Kavelaars, A.3
  • 2
    • 33646162635 scopus 로고    scopus 로고
    • Grks and beta-Arrestins: Roles in receptor silencing, trafficking and signaling
    • Reiter, E., and R. J. Lefkowitz. 2006. GRKs and beta-Arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol. Metab. 17: 159-165.
    • (2006) Trends Endocrinol. Metab , vol.17 , pp. 159-165
    • Reiter, E.1    Lefkowitz, R.J.2
  • 4
    • 0027481032 scopus 로고
    • The binding site for the βγ subunits of heterotrimeric G proteins on the β-adrenergic receptor kinase
    • Koch, W. J., J. Inglese, W. C. Stone, and R. J. Lefkowitz. 1993. The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-Adrenergic receptor kinase. J. Biol. Chem. 268: 8256-8260. (Pubitemid 23120415)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.11 , pp. 8256-8260
    • Koch, W.J.1    Inglese, J.2    Stone, W.C.3    Lefkowitz, R.J.4
  • 5
    • 0029065981 scopus 로고
    • Effect of cellular expression of pleckstrin homology domains on gi-coupled receptor signaling
    • Luttrell, L. M., B. E. Hawes, K. Touhara, T. van Biesen, W. J. Koch, and R. J. Lefkowitz. 1995. Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling. J. Biol. Chem. 270: 12984-12989.
    • (1995) J. Biol. Chem , vol.270 , pp. 12984-12989
    • Luttrell, L.M.1    Hawes, B.E.2    Touhara, K.3    Van Biesen, T.4    Koch, W.J.5    Lefkowitz, R.J.6
  • 6
  • 8
    • 0028300574 scopus 로고
    • Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases
    • Premont, R. T., W. J. Koch, J. Inglese, and R. J. Lefkowitz. 1994. Identification, purification, and characterization of GRK5, a member of the family of G proteincoupled receptor kinases. J. Biol. Chem. 269: 6832-6841. (Pubitemid 24191077)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.9 , pp. 6832-6841
    • Premont, R.T.1    Koch, W.J.2    Inglese, J.3    Lefkowitz, R.J.4
  • 9
    • 0028030060 scopus 로고
    • Palmitoylation of g protein-coupled receptor kinase, grk6. Lipid modification diversity in the grk family
    • Stoffel, R. H., R. R. Randall, R. T. Premont, R. J. Lefkowitz, and J. Inglese. 1994. Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. J. Biol. Chem. 269: 27791-27794.
    • (1994) J. Biol. Chem , vol.269 , pp. 27791-27794
    • Stoffel, R.H.1    Randall, R.R.2    Premont, R.T.3    Lefkowitz, R.J.4    Inglese, J.5
  • 14
    • 0032508720 scopus 로고    scopus 로고
    • Differential cross-regulation of the human chemokine receptors CXCR1 and CXCR2. Evidence for time-dependent signal generation
    • DOI 10.1074/jbc.273.37.23830
    • Richardson, R. M., B. C. Pridgen, B. Haribabu, H. Ali, and R. Snyderman. 1998. Differential cross-regulation of the human chemokine receptors CXCR1 and CXCR2. Evidence for time-dependent signal generation. J. Biol. Chem. 273: 23830-23836. (Pubitemid 28435718)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.37 , pp. 23830-23836
    • Richardson, R.M.1    Pridgen, B.C.2    Haribabu, B.3    Ali, H.4    Snyderman, R.5
  • 15
    • 0037443490 scopus 로고    scopus 로고
    • Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation
    • Richardson, R. M., R. J. Marjoram, L. S. Barak, and R. Snyderman. 2003. Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation. J. Immunol. 170: 2904-2911. (Pubitemid 36302161)
    • (2003) Journal of Immunology , vol.170 , Issue.6 , pp. 2904-2911
    • Richardson, R.M.1    Marjoram, R.J.2    Barak, L.S.3    Snyderman, R.4
  • 16
    • 0035936552 scopus 로고    scopus 로고
    • Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization
    • DOI 10.1021/bi001661b
    • Fan, G. H., W. Yang, X. J.Wang, Q. Qian, and A. Richmond. 2001. Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization. Biochemistry 40: 791-800. (Pubitemid 32096864)
    • (2001) Biochemistry , vol.40 , Issue.3 , pp. 791-800
    • Fan, G.-H.1    Yang, W.2    Wang, X.-J.3    Qian, Q.4    Richmond, A.5
  • 17
    • 18944394203 scopus 로고    scopus 로고
    • Crossdesensitization among cxcr1, cxcr2, and ccr5: Role of protein kinase cepsilon
    • Nasser, M. W., R. J. Marjoram, S. L. Brown, and R. M. Richardson. 2005. Crossdesensitization among CXCR1, CXCR2, and CCR5: role of protein kinase Cepsilon. J. Immunol. 174: 6927-6933.
    • (2005) J. Immunol , vol.174 , pp. 6927-6933
    • Nasser, M.W.1    Marjoram, R.J.2    Brown, S.L.3    Richardson, R.M.4
  • 18
    • 0028858142 scopus 로고
    • Regulation of human interleukin-8 receptor a: Identification of a phosphorylation site involved in modulating receptor functions
    • Richardson, R. M., R. A. DuBose, H. Ali, E. D. Tomhave, B. Haribabu, and R. Snyderman. 1995. Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions. Biochemistry 34: 14193-14201.
    • (1995) Biochemistry , vol.34 , pp. 14193-14201
    • Richardson, R.M.1    DuBose, R.A.2    Ali, H.3    Tomhave, E.D.4    Haribabu, B.5    Snyderman, R.6
  • 19
    • 84866149276 scopus 로고    scopus 로고
    • The chemokine receptors cxcr1 and cxcr2 couple to distinct g protein-coupled receptor kinases to mediate and regulate leukocyte functions
    • Raghuwanshi, S. K., Y. Su, V. Singh, K. Haynes, A. Richmond, and R. M. Richardson. 2012. The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions. J. Immunol. 189: 2824-2832.
    • (2012) J. Immunol , Issue.189 , pp. 2824-2832
    • Raghuwanshi, S.K.1    Su, Y.2    Singh, V.3    Haynes, K.4    Richmond, A.5    Richardson, R.M.6
  • 21
    • 45949097905 scopus 로고    scopus 로고
    • Depletion of beta-Arrestin-2 promotes tumor growth and angiogenesis in a murine model of lung cancer
    • Raghuwanshi, S. K., M. W. Nasser, X. Chen, R.M. Strieter, and R.M. Richardson. 2008. Depletion of beta-Arrestin-2 promotes tumor growth and angiogenesis in a murine model of lung cancer. J. Immunol. 180: 5699-5706.
    • (2008) J. Immunol , vol.180 , pp. 5699-5706
    • Raghuwanshi, S.K.1    Nasser, M.W.2    Chen, X.3    Strieter, R.M.4    Richardson, R.M.5
  • 23
    • 1342324748 scopus 로고    scopus 로고
    • Depletion of CXCR2 Inhibits Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer
    • Keane, M. P., J. A. Belperio, Y. Y. Xue, M. D. Burdick, and R. M. Strieter. 2004. Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer. J. Immunol. 172: 2853-2860. (Pubitemid 38263670)
    • (2004) Journal of Immunology , vol.172 , Issue.5 , pp. 2853-2860
    • Keane, M.P.1    Belperio, J.A.2    Xue, Y.Y.3    Burdick, M.D.4    Strieter, R.M.5
  • 24
    • 40349108482 scopus 로고    scopus 로고
    • Tail vein assay of cancer metastasis
    • Chapter 19:Unit 19.2
    • Elkin, M., and I. Vlodavsky. 2001. Tail vein assay of cancer metastasis. Curr. Protoc. Cell Biol. Chapter 19:Unit 19.2.
    • (2001) Curr. Protoc. Cell Biol
    • Elkin, M.1    Vlodavsky, I.2
  • 25
    • 0034892043 scopus 로고    scopus 로고
    • Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer
    • Schmalfeldt, B., D. Prechtel, K. Harting, K. Spathe, S. Rutke, E. Konik, R. Fridman, U. Berger, M. Schmitt, W. Kuhn, and E. Lengyel. 2001. Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinasetype plasminogen activator is associated with progression from benign to advanced ovarian cancer. Clin. Cancer Res. 7: 2396-2404. (Pubitemid 32751641)
    • (2001) Clinical Cancer Research , vol.7 , Issue.8 , pp. 2396-2404
    • Schmalfeldt, B.1    Prechtel, D.2    Harting, K.3    Spathe, K.4    Rutke, S.5    Konik, E.6    Fridman, R.7    Berger, U.8    Schmitt, M.9    Kuhn, W.10    Lengyel, E.11
  • 26
    • 84859508075 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 regulates survival of neurons in newborn hippocampus
    • Murase, S., and R. D. McKay. 2012. Matrix metalloproteinase-9 regulates survival of neurons in newborn hippocampus. J. Biol. Chem. 287: 12184-12194.
    • (2012) J. Biol. Chem , Issue.287 , pp. 12184-12194
    • Murase, S.1    McKay, R.D.2
  • 28
    • 31544456603 scopus 로고    scopus 로고
    • Distinct expression of CXCL8 and its receptors CXCR1 and CXCR2 and their association with vessel density and aggressiveness in malignant melanoma
    • DOI 10.1309/VPL5-R3JR-7F1D-6V03
    • Varney, M. L., S. L. Johansson, and R. K. Singh. 2006. Distinct expression of CXCL8 and its receptors CXCR1 and CXCR2 and their association with vessel density and aggressiveness in malignant melanoma. Am. J. Clin. Pathol. 125: 209-216. (Pubitemid 43167161)
    • (2006) American Journal of Clinical Pathology , vol.125 , Issue.2 , pp. 209-216
    • Varney, M.L.1    Johansson, S.L.2    Singh, R.K.3
  • 29
    • 0347510969 scopus 로고    scopus 로고
    • Expression of CXCR1 and CXCR2 receptors in malignant melanoma with different metastatic potential and their role in interleukin-8 (CXCL-8) -mediated modulation of metastatic phenotype
    • DOI 10.1023/B:CLIN.0000006814.48627.bd
    • Varney, M. L., A. Li, B. J. Dave, C. D. Bucana, S. L. Johansson, and R. K. Singh. 2003. Expression of CXCR1 and CXCR2 receptors in malignant melanoma with different metastatic potential and their role in interleukin-8 (CXCL-8)-mediated modulation of metastatic phenotype. Clin. Exp. Metastasis 20: 723-731. (Pubitemid 38019274)
    • (2003) Clinical and Experimental Metastasis , vol.20 , Issue.8 , pp. 723-731
    • Varney, M.L.1    Li, A.2    Dave, B.J.3    Bucana, C.D.4    Johansson, S.L.5    Singh, R.K.6
  • 30
    • 0346751951 scopus 로고    scopus 로고
    • Pleiotropic effects of CXC chemokines in gastric carcinoma: Differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma
    • DOI 10.1111/j.1365-2249.2003.02305.x
    • Eck, M., B. Schmausser, K. Scheller, S. Brandlein, and H. K. Muller-Hermelink. 2003. Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma. Clin. Exp. Immunol. 134: 508-515. (Pubitemid 37542093)
    • (2003) Clinical and Experimental Immunology , vol.134 , Issue.3 , pp. 508-515
    • Eck, M.1    Schmausser, B.2    Scheller, K.3    Brandlein, S.4    Muller-Hermelink, H.K.5
  • 31
    • 11244328119 scopus 로고    scopus 로고
    • Interleukin-8/CXCL8 is a growth factor for human lung cancer cells
    • DOI 10.1038/sj.bjc.6602227
    • Zhu, Y. M., S. J. Webster, D. Flower, and P. J. Woll. 2004. Interleukin-8/CXCL8 is a growth factor for human lung cancer cells. Br. J. Cancer 91: 1970-1976. (Pubitemid 40065527)
    • (2004) British Journal of Cancer , vol.91 , Issue.11 , pp. 1970-1976
    • Zhu, Y.M.1    Webster, S.J.2    Flower, D.3    Woll, P.J.4
  • 33
    • 58349094537 scopus 로고    scopus 로고
    • Host cxcr2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis
    • Singh, S., M. Varney, and R. K. Singh. 2009. Host CXCR2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis. Cancer Res. 69: 411-415.
    • (2009) Cancer Res , vol.69 , pp. 411-415
    • Singh, S.1    Varney, M.2    Singh, R.K.3
  • 37
    • 0032160033 scopus 로고    scopus 로고
    • Complex role of matrix metalloproteinases in angiogenesis
    • Sang, Q. X. A. 1998. Complex role of matrix metalloproteinases in angiogenesis. Cell Res. 8: 171-177. (Pubitemid 128544277)
    • (1998) Cell Research , vol.8 , Issue.3 , pp. 171-177
    • Sang, Q.X.A.1
  • 38
    • 0037316605 scopus 로고    scopus 로고
    • Matrix metalloproteinases, angiogenesis, and cancer: Commentary re: A. C. Lockhart et al., reduction of wound angiogenesis in patients treated with bms-275291, a broad spectrum matrix metalloproteinase inhibitor
    • 00-002003
    • Rundhaug, J. E. 2003. Matrix metalloproteinases, angiogenesis, and cancer: commentary re: A. C. Lockhart et al., Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor. Clin. Cancer Res., 9: 00-00, 2003.
    • (2003) Clin. Cancer Res. , vol.9
    • Rundhaug, J.E.1
  • 40
    • 24044459285 scopus 로고    scopus 로고
    • Matrix metalloproteinases and angiogenesis
    • Rundhaug, J. E. 2005. Matrix metalloproteinases and angiogenesis. J. Cell. Mol. Med. 9: 267-285.
    • (2005) J. Cell. Mol. Med , vol.9 , pp. 267-285
    • Rundhaug, J.E.1
  • 41
    • 0037443760 scopus 로고    scopus 로고
    • IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis
    • Li, A., S. Dubey, M. L. Varney, B. J. Dave, and R. K. Singh. 2003. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J. Immunol. 170: 3369-3376. (Pubitemid 36302216)
    • (2003) Journal of Immunology , vol.170 , Issue.6 , pp. 3369-3376
    • Li, A.1    Dubey, S.2    Varney, M.L.3    Dave, B.J.4    Singh, R.K.5
  • 42
    • 24044522259 scopus 로고    scopus 로고
    • Autocrine role of interleukin-8 in induction of endothelial cell proliferation, survival, migration and MMP-2 production and angiogenesis
    • DOI 10.1007/s10456-005-5208-4
    • Li, A., M. L. Varney, J. Valasek, M. Godfrey, B. J. Dave, and R. K. Singh. 2005. Autocrine role of interleukin-8 in induction of endothelial cell proliferation, survival, migration and MMP-2 production and angiogenesis. Angiogenesis 8: 63-71. (Pubitemid 41223840)
    • (2005) Angiogenesis , vol.8 , Issue.1 , pp. 63-71
    • Li, A.1    Varney, M.L.2    Valasek, J.3    Godfrey, M.4    Dave, B.J.5    Singh, R.K.6
  • 46
    • 20444436687 scopus 로고    scopus 로고
    • Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1
    • DOI 10.1016/j.cyto.2005.02.005, PII S1043466605000815
    • Fu, W., Y. Zhang, J. Zhang, and W.-F. Chen. 2005. Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1. Cytokine 31: 9-17. (Pubitemid 40828354)
    • (2005) Cytokine , vol.31 , Issue.1 , pp. 9-17
    • Fu, W.1    Zhang, Y.2    Zhang, J.3    Chen, W.-F.4
  • 47
    • 29144467674 scopus 로고    scopus 로고
    • A homolog of the human chemokine receptor CXCR1 is expressed in the mouse
    • DOI 10.1016/j.molimm.2005.06.043, PII S016158900500218X
    • Moepps, B., E. Nuesseler, M. Braun, and P. Gierschik. 2006. A homolog of the human chemokine receptor CXCR1 is expressed in the mouse. Mol. Immunol. 43: 897-914. (Pubitemid 41814408)
    • (2006) Molecular Immunology , vol.43 , Issue.7 , pp. 897-914
    • Moepps, B.1    Nuesseler, E.2    Braun, M.3    Gierschik, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.