A Competitive Infection Model of Hematogenously Disseminated Candidiasis in Mice Redefines the Role of Candida albicans IRS4 in Pathogenesis

Infection and Immunity

Volumn 81, Issue 5, 2013, Pages 1430-1438

  Raman, Suresh B ^a   Nguyen, M Hong ^a   Cheng, Shaoji ^a   Badrane, Hassan ^a   Gaffen, Sarah L ^a   Wegener, Marilyn ^b   Clancy, Cornelius J ^a,b   Iczkowski, Kenneth A ^c   Mitchell, Aaron P ^d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL (4,5) BISPHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS GROWTH; FUNGUS MUTANT; GENE DISRUPTION; GENE EXPRESSION; IN VITRO STUDY; INFLAMMATION; INVASIVE CANDIDIASIS; IRS4 GENE; MACROPHAGE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

ANALYSIS OF VARIANCE; ANIMALS; CANDIDA ALBICANS; CANDIDIASIS; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; KIDNEY; MALE; MICE; MICE, INBRED ICR; MICROARRAY ANALYSIS; MICROBIAL INTERACTIONS; PHAGOCYTOSIS; POLYMERASE CHAIN REACTION; SPECIES SPECIFICITY;

EID: 84877804290     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00743-12     Document Type: Article

References (32)

1. Pfaller MA, Diekema DJ. 2010. Epidemiology of invasive mycoses in North America. Crit. Rev. Microbiol. 36:1-53.
2. Edmond MB, Wallace SE, McClish DK, Pfaller MA, Jones RN, Wenzel RP. 1999. Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin. Infect. Dis. 29:239-244.
3. Gudlaugsson O, Gillespie S, Lee K, Vande Berg J, Hu J, Messer S, Herwaldt L, Pfaller M, Diekema D. 2003. Attributable mortality of nosocomial candidemia, revisited. Clin. Infect. Dis. 37:1172-1177.
4. Badrane H, Cheng S, Nguyen MH, Jia HY, Zhang Z, Weisner N, Clancy CJ. 2005. Candida albicans IRS4 contributes to hyphal formation and virulence after the initial stages of disseminated candidiasis. Microbiology 151:2923-2931.
5. Badrane H, Nguyen MH, Cheng S, Kumar V, Derendorf H, Iczkowski KA, Clancy CJ. 2008. The Candida albicans phosphatase Inp51p interacts with the EH domain protein Irs4p, regulates phosphatidylinositol-4,5- bisphosphate levels and influences hyphal formation, the cell integrity pathway and virulence. Microbiology 154:3296-3308.
6. Badrane H, Nguyen MH, Blankenship JR, Cheng S, Hao B, Mitchell AP, Clancy CJ. 2012. Rapid redistribution of phosphatidylinositol-(4,5)- bisphosphate and septins during the Candida albicans response to caspofungin. Antimicrob. Agents Chemother. 56:4614-4624.
7. Clancy CJ, Cheng S, Nguyen MH. 2009. Animal models of candidiasis. Methods Mol. Biol. 499:65-76.
8. Ben-Ami R, Garcia-Effron G, Lewis RE, Gamarra S, Leventakos K,Perlin DS, Kontoyiannis DP. 2011. Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance. J. Infect. Dis. 204:626-635.
9. Beuzon CR, Holden DW. 2001. Use of mixed infections with Salmonella strains to study virulence genes and their interactions in vivo. Microbes Infect. 3:1345-1352.
10. Chen C, Pande K, French SD, Tuch BB, Noble SM. 2011. An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis. Cell Host Microbe 10:118-135.
11. Cowen LE, Kohn LM, Anderson JB. 2001. Divergence in fitness and evolution of drug resistance in experimental populations of Candida albicans. J. Bacteriol. 183:2971-2978.
12. Ferrari S, Sanguinetti M, De Bernardis F, Torelli R, Posteraro B, Vandeputte P, Sanglard D. 2011. Loss of mitochondrial functions associated with azole resistance in Candida glabrata results in enhanced virulence in mice. Antimicrob. Agents Chemother. 55:1852-1860.
13. Lockhart SR, Wu W, Radke JB, Zhao R, Soll DR. 2005. Increased virulence and competitive advantage of a/alpha over a/a or alpha/alpha offspring conserves the mating system of Candida albicans. Genetics 169: 1883-1890.
14. Macho AP, Zumaquero A, Ortiz-Martin I, Beuzon CR. 2007. Competitive index in mixed infections: a sensitive and accurate assay for the genetic analysis of Pseudomonas syringae-plant interactions. Mol. Plant Pathol. 8:437- 450.
15. Noble SM, French S, Kohn LA, Chen V, Johnson AD. 2010. Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. Nat. Genet. 42:590-598.
16. White SJ, Rosenbach A, Lephart P, Nguyen D, Benjamin A, Tzipori S, Whiteway M, Mecsas J, Kumamoto CA. 2007. Self-regulation of Candida albicans population size during GI colonization. PLoS Pathog. 3:e184.
17. Gillum AM, Tsay EY, Kirsch DR. 1984. Isolation of the Candida albicans gene for orotidine-5=-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol. Gen. Genet. 198:179-182.
18. Porta A, Ramon AM, Fonzi WA. 1999. PRR1, a homolog of Aspergillus nidulans palF, controls pH-dependent gene expression and filamentation in Candida albicans. J. Bacteriol. 181:7516-7523.
19. Cheng S, Clancy CJ, Zhang Z, Hao B, Wang W, Iczkowski KA, Pfaller MA, Nguyen MH. 2007. Uncoupling of oxidative phosphorylation enables Candida albicans to resist killing by phagocytes and persist in tissue. Cell. Microbiol. 9:492-501.
20. Bowman JC, Abruzzo GK, Anderson JW, Flattery AM, Gill CJ, Pikounis VB, Schmatz DM, Liberator PA, Douglas CM. 2001. Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetate. Antimicrob. Agents Chemother. 45:3474-3481.
21. Meister H, Heymer B, Schäfer H, Haferkamp O. 1977. Role of Candida albicans in granulomatous tissue reactions. II. In vivo degradation of C. albicans in hepatic macrophages of mice. J. Infect. Dis. 135:235-242.
22. Vonk AG, Netea MG, Kullberg BJ. 2012. Phagocytosis and intracellular killing of Candida albicans by murine polymorphonuclear neutrophils. Methods Mol. Biol. 845:277-287.
23. Fradin C, Kretschmar M, Nichterlein T, Gaillardin C, d'Enfert C, Hube B. 2003. Stage-specific gene expression of Candida albicans in human blood. Mol. Microbiol. 47:1523-1543.
24. Tusher VG, Tibshirani R, Chu G. 2001. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U. S. A. 98:5116-5121.
25. Eisen MB, Spellman PT, Brown PO, Botstein D. 1998. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. U. S. A. 95:14863-14868.
26. Shields RK, Nguyen MH, Du C, Press E, Cheng S, Clancy CJ. 2011. Paradoxical effect of caspofungin against Candida bloodstream isolates is mediated by multiple pathways but eliminated in human serum. Antimicrob. Agents Chemother. 55:2641-2647.
27. Netea MG, Brown GD, Kullberg BJ, Gow NA. 2008. An integrated model of the recognition of Candida albicans by the innate immune system. Nat. Rev. Microbiol. 6:67-78.
28. Sheth CC, Hall R, Lewis L, Brown AJ, Odds FC, Erwig LP, Gow NA. 2011. Glycosylation status of the C. albicans cell wall affects the efficiency of neutrophil phagocytosis and killing but not cytokine signaling. Med. Mycol. 49:513-524.
29. Blankenship JR, Fanning S, Hamaker JJ, Mitchell AP. 2010. An extensive circuitry for cell wall regulation in Candida albicans. PLoS Pathog. 6:e1000752.
30. Dagley MJ, Gentle IE, Beilharz TH, Pettolino FA, Djordjevic JT, Lo TL, Uwamahoro N, Rupasinghe T, Tull DL, McConville M, Beaurepaire C, Nantel A, Lithgow T, Mitchell AP, Traven A. 2011. Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post-transcriptional regulator Ccr4-Pop2. Mol. Microbiol. 79:968-989.
31. Gozalbo D, Roig P, Villamon E, Gil ML. 2004. Candida and candidiasis: the cell wall as a potential molecular target for antifungal therapy. Curr. Drug Targets Infect. Disord. 4:117-135.
32. Lewis LE, Bain JM, Lowes C, Gillespie C, Rudkin FM, Gow NA, Erwig LP. 2012. Stage specific assessment of Candida albicans phagocytosis by macrophages identifies cell wall composition and morphogenesis as key determinants. PLoS Pathog. 8:e1002578.