Renal function is independently associated with red cell distribution width in kidney transplant recipients: A potential new auxiliary parameter for the clinical evaluation of patients with chronic kidney disease

British Journal of Haematology

Volumn 161, Issue 5, 2013, Pages 715-725

  Ujszaszi, Akos ^a,b   Molnar, Miklos Z ^a,b,c   Czira, Maria E ^a   Novak, Marta ^a,c   Mucsi, Istvan ^a,d  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

Glomerular filtration rate; Kidney transplantation; Red cell distribution width; Renal function

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; ERYTHROPOIETIN; EVEROLIMUS; HEMOGLOBIN; IMMUNOSUPPRESSIVE AGENT; IRON; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; RAPAMYCIN; TACROLIMUS;

ACUTE GRAFT REJECTION; ADULT; AGE DISTRIBUTION; ARTICLE; BONE MINERAL; CELLULAR PARAMETERS; CHRONIC KIDNEY DISEASE; CLINICAL EVALUATION; COMORBIDITY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DRUG USE; FEMALE; GLOMERULUS FILTRATION RATE; GRAFT RECIPIENT; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON BLOOD LEVEL; KIDNEY GRAFT REJECTION; MAJOR CLINICAL STUDY; MALE; MINERAL METABOLISM; NUTRITIONAL STATUS; OBESITY; PRIORITY JOURNAL; RED CELL DISTRIBUTION WIDTH; SEX DIFFERENCE;

ADULT; AGED; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; ERYTHROCYTE INDICES; FEMALE; GLOMERULAR FILTRATION RATE; HEMOGLOBINS; HUMANS; INFLAMMATION MEDIATORS; KIDNEY; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; PROGNOSIS; RENAL INSUFFICIENCY, CHRONIC;

EID: 84877798885     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12315     Document Type: Article

References (36)

1. Afonso, L., Zalawadiya, S.K., Veeranna, V., Panaich, S.S., Niraj, A. & Jacob, S. (2011) Relationship between red cell distribution width and microalbuminuria: a population-based study of multiethnic representative US adults. Nephron Clinical Practice, 119, c277-c282.
2. Afzali, B., Al-Khoury, S., Shah, N., Mikhail, A., Covic, A. & Goldsmith, D. (2006) Anemia after renal transplantation. American Journal of Kidney Diseases, 48, 519-536.
3. Bion, J.F. (2000) Susceptibility to critical illness: reserve, response and therapy. Intensive Care Medicine, 26, S57-S63.
4. Buckalew, V.M. Jr, Berg, R.L., Wang, S.R., Porush, J.G., Rauch, S. & Schulman, G. (1996) Prevalence of hypertension in 1, 795 subjects with chronic renal disease: the modification of diet in renal disease study baseline cohort. Modification of Diet in Renal Disease Study Group. American Journal of Kidney Diseases, 28, 811-821.
5. Chiari, M.M., Bagnoli, R., De Luca, P.D., Monti, M., Rampoldi, E. & Cunietti, E. (1995) Influence of acute inflammation on iron and nutritional status indexes in older inpatients. Journal of the American Geriatrics Soceity, 43, 767-771.
6. Cooper, B.A., Branley, P., Bulfone, L., Collins, J.F., Craig, J.C., Fraenkel, M.B., Harris, A., Johnson, D.W., Kesselhut, J., Li, J.J., Luxton, G., Pilmore, A., Tiller, D.J., Harris, D.C. & Pollock, C.A; Ideal study. (2010) A randomized, controlled trial of early versus late initiation of dialysis. The New England Journal of Medicine, 363, 609-619.
7. De Lurdes Agostinho Cabrita, A., Pinho, A., Malho, A., Morgado, E., Faisca, M., Carrasqueira, H., Silva, A.P. & Neves, P.L. (2011) Risk factors for high erythropoiesis stimulating agent resistance index in pre-dialysis chronic kidney disease patients, stages 4 and 5. International Urology and Nephrology, 43, 835-840.
8. Docci, D., Delvecchio, C., Gollini, C., Turci, F., Baldrati, L. & Gilli, P. (1989) Red blood cell volume distribution width (RDW) in uraemic patients on chronic haemodialysis. The International Journals of Artificial Organs, 12, 170-174.
9. Evans, T.C. & Jehle, D. (1991) The red blood cell distribution width. The Journal of Emergency Medicine, 9, 71-74.
10. Felker, G.M., Allen, L.A., Pocock, S.J., Shaw, L.K., McMurray, J.J., Pfeffer, M.A., Swedberg, K., Wang, D., Yusuf, S., Michelson, E.L., Granger, C.B.CHARM Investigators. (2007) Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. Journal of the American College Cardiology, 50, 40-47.
11. Goicoechea, M., Martin, J., de Sequera, P., Quiroga, J.A., Ortiz, A., Carreno, V. & Caramelo, C. (1998) Role of cytokines in the response to erythropoietin in hemodialysis patients. Kidney International, 54, 1337-1343.
12. Jassal, S.V., Schaubel, D.E. & Fenton, S.S. (2005) Baseline comorbidity in kidney transplant recipients: a comparison of comorbidity indices. American Journal of Kidney Diseases, 46, 136-142.
13. Karnad, A. & Poskitt, T.R. (1985) The automated complete blood cell count. Use of the red blood cell volume distribution width and mean platelet volume in evaluating anemia and thrombocytopenia. Archives of Internal Medicine, 145, 1270-1272.
14. Kopple, J.D., Greene, T., Chumlea, W.C., Hollinger, D., Maroni, B.J., Merrill, D., Scherch, L.K., Schulman, G., Wang, S.R. & Zimmer, G.S. (2000) Relationship between nutritional status and the glomerular filtration rate: results from the MDRD study. Kidney International, 57, 1688-1703.
15. Kovesdy, C.P., Czira, M.E., Rudas, A., Ujszaszi, A., Rosivall, L., Novak, M., Kalantar-Zadeh, K., Molnar, M.Z. & Mucsi, I. (2010a) Body mass index, waist circumference and mortality in kidney transplant recipients. American Journal of Transplant, 10, 2644-2651.
16. Kovesdy, C.P., Molnar, M.Z., Czira, M.E., Rudas, A., Ujszaszi, A., Rosivall, L., Szathmari, M., Covic, A., Keszei, A., Beko, G., Lakatos, P., Kosa, J. & Mucsi, I. (2010b) Associations between serum leptin level and bone turnover in kidney transplant recipients. Clinical Journal of the American Soceity Nephrology, 5, 2297-2304.
17. Kovesdy, C.P., Mucsi, I., Czira, M.E., Rudas, A., Ujszaszi, A., Rosivall, L., Kim, S.J., Wolf, M. & Molnar, M.Z. (2011) Association of serum phosphorus level with anemia in kidney transplant recipients. Transplantation, 91, 875-882.
18. Lappe, J.M., Horne, B.D., Shah, S.H., May, H.T., Muhlestein, J.B., Lappe, D.L., Kfoury, A.G., Carlquist, J.F., Budge, D., Alharethi, R., Bair, T.L., Kraus, W.E. & Anderson, J.L. (2011) Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population. Clinica Chimica Acta, 412, 2094-2099.
19. Levey, A.S., Stevens, L.A., Schmid, C.H., Zhang, Y.L., Castro, A.F. 3rd, Feldman, H.I., Kusek, J.W., Eggers, P., Van Lente, F., Greene, T. & Coresh, J. (2009) A new equation to estimate glomerular filtration rate. Annals of Internal Medicine, 150, 604-612.
20. Lippi, G., Targher, G., Montagnana, M., Salvagno, G.L., Zoppini, G. & Guidi, G.C. (2008) Relationship between red blood cell distribution width and kidney function tests in a large cohort of unselected outpatients. Scandinavian Journal of Clinical and Laboratory Investigation, 68, 745-748.
21. Molnar, M.Z., Keszei, A., Czira, M.E., Rudas, A., Ujszaszi, A., Haromszeki, B., Kosa, J.P., Lakatos, P., Sarvary, E., Beko, G., Fornadi, K., Kiss, I., Remport, A., Novak, M., Kalantar-Zadeh, K., Kovesdy, C.P. & Mucsi, I. (2010) Evaluation of the malnutrition-inflammation score in kidney transplant recipients. American Journal of Kidney Diseases, 56, 102-111.
22. Molnar, M.Z., Czira, M.E., Rudas, A., Ujszaszi, A., Haromszeki, B., Kosa, J.P., Lakatos, P., Beko, G., Sarvary, E., Varga, M., Fornadi, K., Novak, M., Rosivall, L., Kiss, I., Remport, A., Goldsmith, D.J., Kovesdy, C.P. & Mucsi, I. (2011a) Association between the malnutrition-inflammation score and post-transplant anaemia. Nephrology, Dialysis, Transplantation, 26, 2000-2006.
23. Molnar, M.Z., Czira, M.E., Rudas, A., Ujszaszi, A., Lindner, A., Fornadi, K., Kiss, I., Remport, A., Novak, M., Kennedy, S.H., Rosivall, L., Kovesdy, C.P. & Mucsi, I. (2011b) Association of the malnutrition-inflammation score with clinical outcomes in kidney transplant recipients. American Journal of Kidney Diseases, 58, 101-108.
24. Molnar, M.Z., Tabak, A.G., Alam, A., Czira, M.E., Rudas, A., Ujszaszi, A., Beko, G., Novak, M., Kalantar-Zadeh, K., Kovesdy, C.P. & Mucsi, I. (2011c) Serum erythropoietin level and mortality in kidney transplant recipients. Clinical Journal of the American Soceity of Nephrology, 6, 2879-2886.
25. Mucsi, I., Ujszaszi, A., Czira, E.M., Novak, M. & Molnar, M.Z. (2012) .Red cell distribution width is associated with mortality in kidney transplant recipients. American Journal of Kidney Diseases Submitted unpublished data.
26. Oberg, B.P., McMenamin, E., Lucas, F.L., McMonagle, E., Morrow, J., Ikizler, T.A. & Himmelfarb, J. (2004) Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease. Kidney International, 65, 1009-1016.
27. Oh, H.J., Park, J.T., Kim, J.K., Yoo, D.E., Kim, S.J., Han, S.H., Kang, S.W., Choi, K.H. & Yoo, T.H. (2012) Red blood cell distribution width is an independent predictor of mortality in acute kidney injury patients treated with continuous renal replacement therapy. Nephrology, Dialysis, Transplantation, 27, 589-594.
28. Pascual-Figal, D.A., Bonaque, J.C., Manzano-Fernandez, S., Fernandez, A., Garrido, I.P., Pastor-Perez, F., Lax, A., Valdes, M. & Januzzi, J.L. (2011) Red blood cell distribution width predicts new-onset anemia in heart failure patients. International Journal of Cardiology, 160, 196-200.
29. Patel, K.V., Ferrucci, L., Ershler, W.B., Longo, D.L. & Guralnik, J.M. (2009) Red blood cell distribution width and the risk of death in middle-aged and older adults. Archives of Internal Medicine, 169, 515-523.
30. Patel, K.V., Semba, R.D., Ferrucci, L., Newman, A.B., Fried, L.P., Wallace, R.B., Bandinelli, S., Phillips, C.S., Yu, B., Connelly, S., Shlipak, M.G., Chaves, P.H., Launer, L.J., Ershler, W.B., Harris, T.B., Longo, D.L. & Guralnik, J.M. (2010) Red cell distribution width and mortality in older adults: a meta-analysis. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 65, 258-265.
31. Perlstein, T.S., Weuve, J., Pfeffer, M.A. & Beckman, J.A. (2009) Red blood cell distribution width and mortality risk in a community-based prospective cohort. Archives of Internal Medicine, 169, 588-594.
32. Pierce, C.N. & Larson, D.F. (2005) Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device. Perfusion, 20, 83-90.
33. Sarnak, M.J., Levey, A.S., Schoolwerth, A.C., Coresh, J., Culleton, B., Hamm, L.L., McCullough, P.A., Kasiske, B.L., Kelepouris, E., Klag, M.J., Parfrey, P., Pfeffer, M., Raij, L., Spinosa, D.J. & Wilson, P.W; American Heart Association Councils on Kidney in Cardiovascular Disease, H.B.P.R.C.C., Epidemiology & Prevention (2003) Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation, 108, 2154-2169.
34. Stevens, L.A. & Levin, A. (2003) Anaemia, cardiovascular disease and kidney disease: integrating new knowledge in 2002. Current Opinion in Nephrology and Hypertension, 12, 133-138.
35. Tonelli, M., Sacks, F., Arnold, M., Moye, L., Davis, B. & Pfeffer, M; For the, Cholesterol and Recurrent Events (care) Trial, Investigator. (2008) Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation, 117, 163-168.
36. Vanrenterghem, Y., Ponticelli, C., Morales, J.M., Abramowicz, D., Baboolal, K., Eklund, B., Kliem, V., Legendre, C., Morais Sarmento, A.L. & Vincenti, F. (2003) Prevalence and management of anemia in renal transplant recipients: a European survey. American Journal of Transplantation, 3, 835-845.