Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes

FEBS Letters

Volumn 587, Issue 10, 2013, Pages 1571-1578

  Stevenson, Nigel J ^a   Bourke, Nollaig M ^a   Ryan, Elizabeth J ^a   Binder, Marco ^b   Fanning, Liam ^c   Johnston, James A ^d   Hegarty, John E ^e   Long, Aideen ^a   O'Farrelly, Cliona ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY COLLEGE CORK   (Ireland)

^d QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^e ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Hepatitis C Virus; Interferon; JAK STAT; Proteasome; Ubiquitination

Indexed keywords

ALPHA INTERFERON; JANUS KINASE; MESSENGER RNA; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME DEGRADATION; FEMALE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RNA VIRUS INFECTION; SIGNAL TRANSDUCTION; UBIQUITINATION; VIRUS EXPRESSION;

ADULT; AGED; CELLS, CULTURED; DOWN-REGULATION; FEMALE; HEPACIVIRUS; HEPATOCYTES; HUMANS; IMMUNITY, CELLULAR; INTERFERON-ALPHA; JANUS KINASES; LYMPHOCYTES; MALE; MIDDLE AGED; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS;

HEPATITIS C VIRUS;

EID: 84877790291     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.03.041     Document Type: Article

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