Comparative gene expression analysis of the amygdala in autistic rat models produced by pre- and post-natal exposures to valproic acid

Journal of Toxicological Sciences

Volumn 38, Issue 3, 2013, Pages 391-402

  Oguchi Katayama, Atsuko ^a   Monma, Akihiko ^b   Sekino, Yuko ^a   Moriguchi, Toru ^b   Sato, Kaoru ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b AZABU UNIVERSITY   (Japan)

Author keywords

Amygdala; Microarray; Postnatal; Prenatal; Valproic acid

Indexed keywords

VALPROIC ACID;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; AUTISM; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; MALE; MAZE TEST; MICROARRAY ANALYSIS; NONHUMAN; RAT; SIGNAL TRANSDUCTION; SOCIAL BEHAVIOR;

EID: 84877789398     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.38.391     Document Type: Article

References (10)

1. Blackford, J.U. and Pine, D.S. (2012): Neural substrates of childhood anxiety disorders: a review of neuroimaging findings. Child Adolesc. Psychiatr. Clin. N. Am., 21, 501-525.
2. Etkin, A. and Wager, T.D. (2007): Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am. J. Psychiatry., 164, 1476-1488.
3. Markram, K., Rinaldi, T., Mendola, D.L., Sandi, C. and Markram, H. (2008): Abnormal fear conditioning and amygdala processing in an animal model of autism. Neuropsychopharmacology, 33, 901-912.
4. Neuhaus, E., Beauchaine, T.P. and Bernier, R. (2010): Neurobiological correlates of social functioning in autism. Clin. Psychol. Rev., 30, 733-748.
5. Schneider, T. and Przewtocki, R. (2005): Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism. Neuropsychopharmacology, 30, 80-89.
6. Schneider, T., Ziolkowska, T., Gieryk, T., Tyminska, T. and Przewlocki, R. (2007): Prenatal exposure to valproic acid disturbs the enkephalinergic system functioning, basal hedonic tone, and emotional responses in an animal model of autism. Psychopharmacology, 193, 547-555.
7. Schneider, T., Roman, A., Basta-Kaim, A., Kubera, M., Budziszewska, B., Schneider, K. and Przewtochi, R. (2008): Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid. Psychoneuroendocrinology, 33, 728-740.
8. Wagner, G.C., Reuhl, K.R., Cheh, M., McRae, P. and Halladay, A.K. (2006): A new neurobehavioral model of autism in mice: Pre- and postnatal exposure to sodium valproate. J. Autism. Dev. Disord., 36, 779-793.
9. Yochum, C.L., Dowling, P., Reuhl, K.R., Wagner, G.C. and Ming, X. (2008): VPA-induced apoptosis and behavioral deficits in neonatal mice. Brain Res., 1203, 126-132.
10. Yochum, C.L., Bhattacharya, P., Patti, L., Mirochnitchenko, L. and Wagner, G.C. (2010): Animal model of autism using GSTM1 knockout mice and early post-natal sodium valproate treatment. Behav. Brain Res., 210, 202-210.