메뉴 건너뛰기




Volumn 8, Issue 5, 2013, Pages

Increased Plasma Citrulline in Mice Marks Diet-Induced Obesity and May Predict the Development of the Metabolic Syndrome

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; AROMATIC AMINO ACID; BRANCHED CHAIN AMINO ACID; CITRULLINE; INSULIN; ORNITHINE;

EID: 84877758478     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063950     Document Type: Article
Times cited : (61)

References (59)
  • 1
    • 0035651021 scopus 로고    scopus 로고
    • Tissue-specific regulation of mitochondrial and cytoplasmic protein synthesis rates by insulin
    • Boirie Y, Short KR, Ahlman B, Charlton M, Nair KS, (2001) Tissue-specific regulation of mitochondrial and cytoplasmic protein synthesis rates by insulin. Diabetes 50: 2652-2658.
    • (2001) Diabetes , vol.50 , pp. 2652-2658
    • Boirie, Y.1    Short, K.R.2    Ahlman, B.3    Charlton, M.4    Nair, K.S.5
  • 2
    • 0037134492 scopus 로고    scopus 로고
    • Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells
    • Hyde R, Peyrollier K, Hundal HS, (2002) Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells. J Biol Chem 277: 13628-13634.
    • (2002) J Biol Chem , vol.277 , pp. 13628-13634
    • Hyde, R.1    Peyrollier, K.2    Hundal, H.S.3
  • 3
    • 59449110484 scopus 로고    scopus 로고
    • Regulatory mechanisms of SNAT2, an amino acid transporter, in L6 rat skeletal muscle cells by insulin, osmotic shock and amino acid deprivation
    • Kashiwagi H, Yamazaki K, Takekuma Y, Ganapathy V, Sugawara M, (2009) Regulatory mechanisms of SNAT2, an amino acid transporter, in L6 rat skeletal muscle cells by insulin, osmotic shock and amino acid deprivation. Amino Acids 36: 219-230.
    • (2009) Amino Acids , vol.36 , pp. 219-230
    • Kashiwagi, H.1    Yamazaki, K.2    Takekuma, Y.3    Ganapathy, V.4    Sugawara, M.5
  • 4
    • 55549088220 scopus 로고    scopus 로고
    • Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake
    • Green CJ, Goransson O, Kular GS, Leslie NR, Gray A, et al. (2008) Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake. J Biol Chem 283: 27653-27667.
    • (2008) J Biol Chem , vol.283 , pp. 27653-27667
    • Green, C.J.1    Goransson, O.2    Kular, G.S.3    Leslie, N.R.4    Gray, A.5
  • 5
    • 29244463535 scopus 로고    scopus 로고
    • The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line
    • Gameiro A, Reimann F, Habib AM, O'Malley D, Williams L, et al. (2005) The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line. J Physiol 569: 761-772.
    • (2005) J Physiol , vol.569 , pp. 761-772
    • Gameiro, A.1    Reimann, F.2    Habib, A.M.3    O'Malley, D.4    Williams, L.5
  • 7
    • 0036263720 scopus 로고    scopus 로고
    • A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion
    • Brennan L, Shine A, Hewage C, Malthouse JP, Brindle KM, et al. (2002) A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion. Diabetes 51: 1714-1721.
    • (2002) Diabetes , vol.51 , pp. 1714-1721
    • Brennan, L.1    Shine, A.2    Hewage, C.3    Malthouse, J.P.4    Brindle, K.M.5
  • 8
    • 0347287092 scopus 로고    scopus 로고
    • A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11 - the functional significance of L-alanine
    • Dixon G, Nolan J, McClenaghan N, Flatt PR, Newsholme P, (2003) A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11- the functional significance of L-alanine. J Endocrinol 179: 447-454.
    • (2003) J Endocrinol , vol.179 , pp. 447-454
    • Dixon, G.1    Nolan, J.2    McClenaghan, N.3    Flatt, P.R.4    Newsholme, P.5
  • 9
    • 0032804629 scopus 로고    scopus 로고
    • Nutrient modulation of cellular insulin action
    • Patti ME, (1999) Nutrient modulation of cellular insulin action. Ann N Y Acad Sci 892: 187-203.
    • (1999) Ann N Y Acad Sci , vol.892 , pp. 187-203
    • Patti, M.E.1
  • 10
    • 0035851205 scopus 로고    scopus 로고
    • Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
    • Tremblay F, Marette A, (2001) Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 276: 38052-38060.
    • (2001) J Biol Chem , vol.276 , pp. 38052-38060
    • Tremblay, F.1    Marette, A.2
  • 11
    • 26444575415 scopus 로고    scopus 로고
    • Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
    • Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, et al. (2005) Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A 102: 14238-14243.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 14238-14243
    • Nobukuni, T.1    Joaquin, M.2    Roccio, M.3    Dann, S.G.4    Kim, S.Y.5
  • 12
    • 3543121894 scopus 로고    scopus 로고
    • Effect of high-fat diet on the expression of proteins in muscle, adipose tissues, and liver of C57BL/6 mice
    • Schmid GM, Converset V, Walter N, Sennitt MV, Leung KY, et al. (2004) Effect of high-fat diet on the expression of proteins in muscle, adipose tissues, and liver of C57BL/6 mice. Proteomics 4: 2270-2282.
    • (2004) Proteomics , vol.4 , pp. 2270-2282
    • Schmid, G.M.1    Converset, V.2    Walter, N.3    Sennitt, M.V.4    Leung, K.Y.5
  • 13
    • 57049084022 scopus 로고    scopus 로고
    • Time course of high-fat diet-induced reductions in adipose tissue mitochondrial proteins: potential mechanisms and the relationship to glucose intolerance
    • Sutherland LN, Capozzi LC, Turchinsky NJ, Bell RC, Wright DC, (2008) Time course of high-fat diet-induced reductions in adipose tissue mitochondrial proteins: potential mechanisms and the relationship to glucose intolerance. Am J Physiol Endocrinol Metab 295: E1076-1083.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Sutherland, L.N.1    Capozzi, L.C.2    Turchinsky, N.J.3    Bell, R.C.4    Wright, D.C.5
  • 14
    • 78650732495 scopus 로고    scopus 로고
    • Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women
    • Fiehn O, Garvey WT, Newman JW, Lok KH, Hoppel CL, et al. (2010) Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PLoS One 5: e15234.
    • (2010) PLoS One , vol.5
    • Fiehn, O.1    Garvey, W.T.2    Newman, J.W.3    Lok, K.H.4    Hoppel, C.L.5
  • 15
    • 79953737332 scopus 로고    scopus 로고
    • Metabolite profiles and the risk of developing diabetes
    • Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, et al. (2011) Metabolite profiles and the risk of developing diabetes. Nat Med 17: 448-453.
    • (2011) Nat Med , vol.17 , pp. 448-453
    • Wang, T.J.1    Larson, M.G.2    Vasan, R.S.3    Cheng, S.4    Rhee, E.P.5
  • 16
    • 0014669160 scopus 로고
    • Plasma amino acid levels and insulin secretion in obesity
    • Felig P, Marliss E, Cahill GF, (1969) Plasma amino acid levels and insulin secretion in obesity. N Engl J Med 281: 811-816.
    • (1969) N Engl J Med , vol.281 , pp. 811-816
    • Felig, P.1    Marliss, E.2    Cahill, G.F.3
  • 17
    • 6344226632 scopus 로고    scopus 로고
    • Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes
    • Wijekoon EP, Skinner C, Brosnan ME, Brosnan JT, (2004) Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes. Can J Physiol Pharmacol 82: 506-514.
    • (2004) Can J Physiol Pharmacol , vol.82 , pp. 506-514
    • Wijekoon, E.P.1    Skinner, C.2    Brosnan, M.E.3    Brosnan, J.T.4
  • 18
    • 37149027613 scopus 로고    scopus 로고
    • Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism
    • She P, Van Horn C, Reid T, Hutson SM, Cooney RN, et al. (2007) Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. Am J Physiol Endocrinol Metab 293: E1552-1563.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • She, P.1    Van Horn, C.2    Reid, T.3    Hutson, S.M.4    Cooney, R.N.5
  • 19
    • 79960840896 scopus 로고    scopus 로고
    • Time-dependent changes in the plasma amino acid concentration in diabetes mellitus
    • Mochida T, Tanaka T, Shiraki Y, Tajiri H, Matsumoto S, et al. (2011) Time-dependent changes in the plasma amino acid concentration in diabetes mellitus. Mol Genet Metab 103: 406-409.
    • (2011) Mol Genet Metab , vol.103 , pp. 406-409
    • Mochida, T.1    Tanaka, T.2    Shiraki, Y.3    Tajiri, H.4    Matsumoto, S.5
  • 20
    • 0020062475 scopus 로고
    • Branched-chain amino acids and alanine as indices of the metabolic control in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients
    • Vannini P, Marchesini G, Forlani G, Angiolini A, Ciavarella A, et al. (1982) Branched-chain amino acids and alanine as indices of the metabolic control in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients. Diabetologia 22: 217-219.
    • (1982) Diabetologia , vol.22 , pp. 217-219
    • Vannini, P.1    Marchesini, G.2    Forlani, G.3    Angiolini, A.4    Ciavarella, A.5
  • 21
    • 79953692640 scopus 로고    scopus 로고
    • The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation
    • Baccini M, Bachmaier EM, Biggeri A, Boekschoten MV, Bouwman FG, et al. (2008) The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation. Genes Nutr 3: 147-151.
    • (2008) Genes Nutr , vol.3 , pp. 147-151
    • Baccini, M.1    Bachmaier, E.M.2    Biggeri, A.3    Boekschoten, M.V.4    Bouwman, F.G.5
  • 22
    • 79955776933 scopus 로고    scopus 로고
    • Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention
    • Rubio-Aliaga I, Roos B, Sailer M, McLoughlin GA, Boekschoten MV, et al. (2011) Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention. Physiol Genomics 43: 408-416.
    • (2011) Physiol Genomics , vol.43 , pp. 408-416
    • Rubio-Aliaga, I.1    Roos, B.2    Sailer, M.3    McLoughlin, G.A.4    Boekschoten, M.V.5
  • 23
    • 78650114495 scopus 로고    scopus 로고
    • Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets
    • Erdely A, Kepka-Lenhart D, Salmen-Muniz R, Chapman R, Hulderman T, et al. (2010) Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets. PLoS One 5: e15253.
    • (2010) PLoS One , vol.5
    • Erdely, A.1    Kepka-Lenhart, D.2    Salmen-Muniz, R.3    Chapman, R.4    Hulderman, T.5
  • 24
    • 65649123397 scopus 로고    scopus 로고
    • Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk
    • Tang WH, Wang Z, Cho L, Brennan DM, Hazen SL, (2009) Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk. J Am Coll Cardiol 53: 2061-2067.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 2061-2067
    • Tang, W.H.1    Wang, Z.2    Cho, L.3    Brennan, D.M.4    Hazen, S.L.5
  • 25
    • 79955552822 scopus 로고    scopus 로고
    • Dose-dependent effects of dietary fat on development of obesity in relation to intestinal differential gene expression in C57BL/6J mice
    • de Wit NJ, Boekschoten MV, Bachmair EM, Hooiveld GJ, de Groot PJ, et al. (2011) Dose-dependent effects of dietary fat on development of obesity in relation to intestinal differential gene expression in C57BL/6J mice. PLoS One 6: e19145.
    • (2011) PLoS One , vol.6
    • de Wit, N.J.1    Boekschoten, M.V.2    Bachmair, E.M.3    Hooiveld, G.J.4    de Groot, P.J.5
  • 26
    • 77956293821 scopus 로고    scopus 로고
    • alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population
    • Gall WE, Beebe K, Lawton KA, Adam KP, Mitchell MW, et al. (2010) alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS One 5: e10883.
    • (2010) PLoS One , vol.5
    • Gall, W.E.1    Beebe, K.2    Lawton, K.A.3    Adam, K.P.4    Mitchell, M.W.5
  • 27
    • 77954457972 scopus 로고    scopus 로고
    • Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits
    • Zhao X, Fritsche J, Wang J, Chen J, Rittig K, et al. (2010) Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits. Metabolomics 6: 362-374.
    • (2010) Metabolomics , vol.6 , pp. 362-374
    • Zhao, X.1    Fritsche, J.2    Wang, J.3    Chen, J.4    Rittig, K.5
  • 28
    • 77952339975 scopus 로고    scopus 로고
    • Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes
    • Connor SC, Hansen MK, Corner A, Smith RF, Ryan TE, (2010) Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes. Mol Biosyst 6: 909-921.
    • (2010) Mol Biosyst , vol.6 , pp. 909-921
    • Connor, S.C.1    Hansen, M.K.2    Corner, A.3    Smith, R.F.4    Ryan, T.E.5
  • 29
    • 77957767313 scopus 로고    scopus 로고
    • Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice
    • Noguchi Y, Nishikata N, Shikata N, Kimura Y, Aleman JO, et al. (2010) Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice. PLoS One 5: e12057.
    • (2010) PLoS One , vol.5
    • Noguchi, Y.1    Nishikata, N.2    Shikata, N.3    Kimura, Y.4    Aleman, J.O.5
  • 31
    • 63449111894 scopus 로고    scopus 로고
    • A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
    • Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, et al. (2009) A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 9: 311-326.
    • (2009) Cell Metab , vol.9 , pp. 311-326
    • Newgard, C.B.1    An, J.2    Bain, J.R.3    Muehlbauer, M.J.4    Stevens, R.D.5
  • 32
    • 77956276702 scopus 로고    scopus 로고
    • Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes
    • Lanza IR, Zhang S, Ward LE, Karakelides H, Raftery D, et al. (2010) Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes. PLoS One 5: e10538.
    • (2010) PLoS One , vol.5
    • Lanza, I.R.1    Zhang, S.2    Ward, L.E.3    Karakelides, H.4    Raftery, D.5
  • 34
    • 84866435571 scopus 로고    scopus 로고
    • Multifactorial risk factor intervention in patients with Type 2 diabetes improves arginine bioavailability ratios
    • Tripolt NJ, Meinitzer A, Eder M, Wascher TC, Pieber TR, et al. (2012) Multifactorial risk factor intervention in patients with Type 2 diabetes improves arginine bioavailability ratios. Diabet Med 29: e365-368.
    • (2012) Diabet Med , vol.29
    • Tripolt, N.J.1    Meinitzer, A.2    Eder, M.3    Wascher, T.C.4    Pieber, T.R.5
  • 35
    • 80052273417 scopus 로고    scopus 로고
    • Arginine bioavailability ratios are associated with cardiovascular mortality in patients referred to coronary angiography
    • Sourij H, Meinitzer A, Pilz S, Grammer TB, Winkelmann BR, et al. (2011) Arginine bioavailability ratios are associated with cardiovascular mortality in patients referred to coronary angiography. Atherosclerosis 218: 220-225.
    • (2011) Atherosclerosis , vol.218 , pp. 220-225
    • Sourij, H.1    Meinitzer, A.2    Pilz, S.3    Grammer, T.B.4    Winkelmann, B.R.5
  • 36
    • 0019750437 scopus 로고
    • Source and fate of circulating citrulline
    • Windmueller HG, Spaeth AE, (1981) Source and fate of circulating citrulline. Am J Physiol 241: E473-480.
    • (1981) Am J Physiol , vol.241
    • Windmueller, H.G.1    Spaeth, A.E.2
  • 37
    • 0017153989 scopus 로고
    • Metabolism of absorbed aspartate, asparagine, and arginine by rat small intestine in vivo
    • Windmueller HG, Spaeth AE, (1976) Metabolism of absorbed aspartate, asparagine, and arginine by rat small intestine in vivo. Arch Biochem Biophys 175: 670-676.
    • (1976) Arch Biochem Biophys , vol.175 , pp. 670-676
    • Windmueller, H.G.1    Spaeth, A.E.2
  • 38
    • 0031967119 scopus 로고    scopus 로고
    • Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets
    • Stoll B, Henry J, Reeds PJ, Yu H, Jahoor F, et al. (1998) Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets. J Nutr 128: 606-614.
    • (1998) J Nutr , vol.128 , pp. 606-614
    • Stoll, B.1    Henry, J.2    Reeds, P.J.3    Yu, H.4    Jahoor, F.5
  • 39
    • 0031008831 scopus 로고    scopus 로고
    • Amino acid handling in uremic rats: citrulline, a reliable marker of renal insufficiency and proximal tubular dysfunction
    • Levillain O, Parvy P, Hassler C, (1997) Amino acid handling in uremic rats: citrulline, a reliable marker of renal insufficiency and proximal tubular dysfunction. Metabolism 46: 611-618.
    • (1997) Metabolism , vol.46 , pp. 611-618
    • Levillain, O.1    Parvy, P.2    Hassler, C.3
  • 40
    • 0025318228 scopus 로고
    • Early alterations of plasma free amino acids in chronic renal failure
    • Ceballos I, Chauveau P, Guerin V, Bardet J, Parvy P, et al. (1990) Early alterations of plasma free amino acids in chronic renal failure. Clin Chim Acta 188: 101-108.
    • (1990) Clin Chim Acta , vol.188 , pp. 101-108
    • Ceballos, I.1    Chauveau, P.2    Guerin, V.3    Bardet, J.4    Parvy, P.5
  • 41
    • 84869229267 scopus 로고    scopus 로고
    • The Effects of Palmitic Acid on Nitric Oxide Production by Rat Skeletal Muscle: Mechanism via Superoxide and iNOS Activation
    • Lambertucci RH, Leandro CG, Vinolo MA, Nachbar RT, Dos Reis Silveira L, et al. (2012) The Effects of Palmitic Acid on Nitric Oxide Production by Rat Skeletal Muscle: Mechanism via Superoxide and iNOS Activation. Cell Physiol Biochem 30: 1169-1180.
    • (2012) Cell Physiol Biochem , vol.30 , pp. 1169-1180
    • Lambertucci, R.H.1    Leandro, C.G.2    Vinolo, M.A.3    Nachbar, R.T.4    Dos Reis Silveira, L.5
  • 42
    • 0034770292 scopus 로고    scopus 로고
    • Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
    • Perreault M, Marette A, (2001) Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 7: 1138-1143.
    • (2001) Nat Med , vol.7 , pp. 1138-1143
    • Perreault, M.1    Marette, A.2
  • 43
    • 33846039463 scopus 로고    scopus 로고
    • Interorgan amino acid exchange in humans: consequences for arginine and citrulline metabolism
    • van de Poll MC, Siroen MP, van Leeuwen PA, Soeters PB, Melis GC, et al. (2007) Interorgan amino acid exchange in humans: consequences for arginine and citrulline metabolism. Am J Clin Nutr 85: 167-172.
    • (2007) Am J Clin Nutr , vol.85 , pp. 167-172
    • van de Poll, M.C.1    Siroen, M.P.2    van Leeuwen, P.A.3    Soeters, P.B.4    Melis, G.C.5
  • 44
    • 0032849897 scopus 로고    scopus 로고
    • Studies of hepatic glutamine metabolism in the perfused rat liver with (15)N-labeled glutamine
    • Nissim I, Brosnan ME, Yudkoff M, Brosnan JT, (1999) Studies of hepatic glutamine metabolism in the perfused rat liver with (15)N-labeled glutamine. J Biol Chem 274: 28958-28965.
    • (1999) J Biol Chem , vol.274 , pp. 28958-28965
    • Nissim, I.1    Brosnan, M.E.2    Yudkoff, M.3    Brosnan, J.T.4
  • 45
    • 84861949901 scopus 로고    scopus 로고
    • Time sequence of the intensification of the liver glucose production induced by high-fat diet in mice
    • Obici S, Tavoni TM, Barrena HC, Curi R, Bazotte RB (2012) Time sequence of the intensification of the liver glucose production induced by high-fat diet in mice. Cell Biochem Funct.
    • (2012) Cell Biochem Funct
    • Obici, S.1    Tavoni, T.M.2    Barrena, H.C.3    Curi, R.4    Bazotte, R.B.5
  • 47
    • 0030669169 scopus 로고    scopus 로고
    • The purified and reconstituted ornithine/citrulline carrier from rat liver mitochondria: electrical nature and coupling of the exchange reaction with H+ translocation
    • Indiveri C, Tonazzi A, Stipani I, Palmieri F, (1997) The purified and reconstituted ornithine/citrulline carrier from rat liver mitochondria: electrical nature and coupling of the exchange reaction with H+ translocation. Biochem J 327 (Pt 2) (): 349-355.
    • (1997) Biochem J , vol.327 , Issue.PART 2 , pp. 349-355
    • Indiveri, C.1    Tonazzi, A.2    Stipani, I.3    Palmieri, F.4
  • 48
    • 0027409441 scopus 로고
    • Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver
    • Closs EI, Albritton LM, Kim JW, Cunningham JM, (1993) Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver. J Biol Chem 268: 7538-7544.
    • (1993) J Biol Chem , vol.268 , pp. 7538-7544
    • Closs, E.I.1    Albritton, L.M.2    Kim, J.W.3    Cunningham, J.M.4
  • 49
    • 0141730371 scopus 로고    scopus 로고
    • Role of L-citrulline transport in nitric oxide synthesis in rat aortic smooth muscle cells activated with LPS and interferon-gamma
    • Wileman SM, Mann GE, Pearson JD, Baydoun AR, (2003) Role of L-citrulline transport in nitric oxide synthesis in rat aortic smooth muscle cells activated with LPS and interferon-gamma. Br J Pharmacol 140: 179-185.
    • (2003) Br J Pharmacol , vol.140 , pp. 179-185
    • Wileman, S.M.1    Mann, G.E.2    Pearson, J.D.3    Baydoun, A.R.4
  • 50
    • 77950839133 scopus 로고    scopus 로고
    • An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle
    • Drummond MJ, Glynn EL, Fry CS, Timmerman KL, Volpi E, et al. (2010) An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle. Am J Physiol Endocrinol Metab 298: E1011-1018.
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Drummond, M.J.1    Glynn, E.L.2    Fry, C.S.3    Timmerman, K.L.4    Volpi, E.5
  • 51
    • 22544465596 scopus 로고    scopus 로고
    • Differential regulation of amino acid transporter SNAT3 by insulin in hepatocytes
    • Gu S, Villegas CJ, Jiang JX, (2005) Differential regulation of amino acid transporter SNAT3 by insulin in hepatocytes. J Biol Chem 280: 26055-26062.
    • (2005) J Biol Chem , vol.280 , pp. 26055-26062
    • Gu, S.1    Villegas, C.J.2    Jiang, J.X.3
  • 52
    • 78649735772 scopus 로고    scopus 로고
    • Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting
    • Suhre K, Meisinger C, Doring A, Altmaier E, Belcredi P, et al. (2010) Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS One 5: e13953.
    • (2010) PLoS One , vol.5
    • Suhre, K.1    Meisinger, C.2    Doring, A.3    Altmaier, E.4    Belcredi, P.5
  • 53
    • 0017295966 scopus 로고
    • Effects of brief starvation on muscle amino acid metabolism in nonobese man
    • Pozefsky T, Tancredi RG, Moxley RT, Dupre J, Tobin JD, (1976) Effects of brief starvation on muscle amino acid metabolism in nonobese man. J Clin Invest 57: 444-449.
    • (1976) J Clin Invest , vol.57 , pp. 444-449
    • Pozefsky, T.1    Tancredi, R.G.2    Moxley, R.T.3    Dupre, J.4    Tobin, J.D.5
  • 54
    • 84862282554 scopus 로고    scopus 로고
    • Emerging Perspectives on Essential Amino Acid Metabolism in Obesity and the Insulin-Resistant State
    • Adams SH, (2011) Emerging Perspectives on Essential Amino Acid Metabolism in Obesity and the Insulin-Resistant State. Advances in Nutrition: An International Review Journal 2: 445-456.
    • (2011) Advances in Nutrition: An International Review Journal , vol.2 , pp. 445-456
    • Adams, S.H.1
  • 55
    • 0020057321 scopus 로고
    • Transaminative metabolism of alpha-amino-n-butyrate in rats
    • Steele RD, (1982) Transaminative metabolism of alpha-amino-n-butyrate in rats. Metabolism 31: 318-325.
    • (1982) Metabolism , vol.31 , pp. 318-325
    • Steele, R.D.1
  • 56
    • 0021282230 scopus 로고
    • Characterization of alpha-ketobutyrate metabolism in rat tissues: effects of dietary protein and fasting
    • Steele RD, Weber H, Patterson JI, (1984) Characterization of alpha-ketobutyrate metabolism in rat tissues: effects of dietary protein and fasting. J Nutr 114: 701-710.
    • (1984) J Nutr , vol.114 , pp. 701-710
    • Steele, R.D.1    Weber, H.2    Patterson, J.I.3
  • 57
    • 80051671254 scopus 로고    scopus 로고
    • Metabolomics of prolonged fasting in humans reveals new catabolic markers
    • Rubio-Aliaga I, Roos B, Duthie S, Crosley L, Mayer C, et al. (2011) Metabolomics of prolonged fasting in humans reveals new catabolic markers. Metabolomics 7: 375-387.
    • (2011) Metabolomics , vol.7 , pp. 375-387
    • Rubio-Aliaga, I.1    Roos, B.2    Duthie, S.3    Crosley, L.4    Mayer, C.5
  • 58
    • 0030667307 scopus 로고    scopus 로고
    • Effect of an elemental vs a complex diet on L-citrulline production from L-arginine in rat isolated enterocytes
    • Guihot G, Blachier F, Colomb V, Morel MT, Raynal P, et al. (1997) Effect of an elemental vs a complex diet on L-citrulline production from L-arginine in rat isolated enterocytes. JPEN J Parenter Enteral Nutr 21: 316-323.
    • (1997) JPEN J Parenter Enteral Nutr , vol.21 , pp. 316-323
    • Guihot, G.1    Blachier, F.2    Colomb, V.3    Morel, M.T.4    Raynal, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.