Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis

Nature

Volumn 497, Issue 7448, 2013, Pages 268-271

  Xu, Ke ^a   Zhang, Minhua ^a   Zhao, Qin ^a   Yu, Fang ^b   Guo, Hui ^a   Wang, Chengyuan ^a   He, Fangyuan ^a   Ding, Jianping ^b   Zhang, Peng ^a  

^a INSTITUTE OF PLANT PHYSIOLOGY AND ECOLOGY   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; AMINOMETHYLTRANSFERASE; FOLATE BINDING PROTEIN; FOLATE ENERGY COUPLING FACTOR TRANSPORTER; FOLIC ACID; NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; VITRONECTIN;

BACTERIUM; CHEMICAL BINDING; CRYSTAL STRUCTURE; CYTOPLASM; HYDROLYSIS; MEMBRANE; PROTEIN; SUBSTRATE;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; HYDROGEN BOND; HYDROLYSIS; LACTOBACILLUS BREVIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID TRANSPORTERS; LACTOBACILLUS BREVIS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN SUBUNITS; PROTEOLIPIDS;

LACTOBACILLUS BREVIS; PROKARYOTA;

EID: 84877756304     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12046     Document Type: Article

References (27)

1. Higgins, C. F. ABC transporters: from microorganisms to man. Annu. Rev. Cell Biol. 8, 67-113 (1992).
2. Rees, D. C., Johnson, E., & Lewinson, O. ABC transporters: the power to change. Nature Rev. Mol. Cell Biol. 10, 218-227 (2009).
3. Locher, K. P., Lee, A. T. & Rees, D. C. The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism. Science 296, 1091-1098 (2002).
4. Hvorup, R. N. et al. Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF. Science 317, 1387-1390 (2007).
5. Hollenstein, K., Frei, D. C.&Locher, K. P. Structure of anABCtransporter in complex with its binding protein. Nature 446, 213-216 (2007).
6. Oldham,M. L.,Khare, D., Quiocho, F. A.,Davidson, A. L.&Chen, J. Crystal structure of a catalytic intermediate of the maltose transporter. Nature 450, 515-521 (2007).
7. Oldham, M. L., & Chen, J. Crystal structure of the maltose transporter in a pretranslocation intermediate state. Science 332, 1202-1205 (2011).
8. Khare, D. Oldham, M. L., Orelle, C., Davidson, A. L. & Chen, J. Alternating access in maltosetransporter mediatedby rigid-bodyrotations. Mol.Cell33,528-536(2009).
9. Oldham, M. L. Davidson, A. L. & Chen, J. Structural insights into ABC transporter mechanism. Curr. Opin. Struct. Biol. 18, 726-733 (2008).
10. Kadaba, N. S., Kaiser, J. T., Johnson, E., Lee, A. & Rees, D. C. The high-affinity E. coli methionine ABC transporter: structure and allosteric regulation. Science 321, 250-253 (2008).
11. Gerber, S., Comellas-Bigler, M., Goetz, B. A. & Locher, K. P. Structural basis of transinhibition in a molybdate/tungstateABCtransporter. Science321,246-250(2008).
12. Rodionov, D. A. et al. A novel class of modular transporters for vitamins in prokaryotes. J. Bacteriol. 191, 42-51 (2009).
13. ter Beek, J., Duurkens, R. H., Erkens, G. B. & Slotboom, D. J. Quaternary structure andfunctionalunit of energy coupling factor (ECF)-type transporters. J. Biol. Chem. 286, 5471-5475 (2011).
14. Erkens, G. B., Majsnerowska, M., Ter Beek, J. & Slotboom, D. J. Energy coupling factor-type ABC transporters for vitamin uptake in prokaryotes. Biochemistry 51, 4390-4396 (2012).
15. Eitinger, T., Rodionov, D. A., Grote, M. & Schneider, E. Canonical and ECF-type ATPbinding cassette importers in prokaryotes: diversity in modular organization and cellular functions. FEMS Microbiol. Rev. 35, 3-67 (2011).
16. Zhang, P., Wang, J. & Shi, Y. Structure and mechanism of the S component of a bacterial ECF transporter. Nature 468, 717-720 (2010).
17. Erkens, G. B. et al. The structural basis ofmodularity in ECF-type ABC transporters. Nature Struct. Mol. Biol. 18, 755-760 (2011).
18. Neubauer, O. et al. Two essential arginine residues in the T components of energycoupling factor transporters. J. Bacteriol. 191, 6482-6488 (2009).
19. Hebbeln, P., Rodionov, D. A., Alfandega, A. & Eitinger, T. Biotin uptake in prokaryotes by solute transporters with an optional ATP-binding cassettecontaining module. Proc. Natl Acad. Sci. USA 104, 2909-2914 (2007).
20. Duurkens, R. H., Tol, M. B., Geertsma, E. R., Permentier, H. P.&Slotboom, D. J. Flavin binding to the high affinity riboflavin transporter RibU. J. Biol. Chem. 282, 10380-10386 (2007).
21. Berntsson, R. P. et al. Structural divergence of paralogous S components from ECF-type ABC transporters. Proc. Natl Acad. Sci. USA 109, 13990-13995 (2012).
22. Eudes, A. et al. Identification of genes encoding the folate-and thiamine-binding membrane proteins in Firmicutes. J. Bacteriol. 190, 7591-7594 (2008).
23. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. A 276, 307-326 (1997).
24. Sheldrick, G. M. Experimental phasing withSHELXC/D/E: combining chain tracing with density modification. Acta Crystallogr. D 66, 479-485 (2010).
25. Adams, P. D. et al. PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr. D 58, 1948-1954 (2002).
26. Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D 60, 2126-2132 (2004).
27. Geertsma, E. R., Nik Mahmood, N. A., Schuurman-Wolters, G. K. & Poolman, B. Membrane reconstitution of ABC transporters and assays of translocator function. Nature Protocols 3, 256-266 (2008).