Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic- and nonantibiotic-related pressure

Molecular Biology and Evolution

Volumn 30, Issue 6, 2013, Pages 1326-1336

  Osório, Nuno S ^a,b   Rodrigues, Fernando ^a,b   Gagneux, Sebastien ^c,d   Pedrosa, Jorge ^a,b   Pinto Carbó, Marta ^e   Castro, António G ^a,b   Young, Douglas ^f,g   Comas, Iñaki ^e,h   Saraiva, Margarida ^a,b  

^a UNIVERSITY OF MINHO   (Portugal)

^b UNIVERSITY OF MINHO   (Portugal)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

^e Centre for Public Health Research CSISP   (Spain)

^f NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^g IMPERIAL COLLEGE LONDON   (United Kingdom)

^h CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

Author keywords

computational molecular biology; diversifying selection; drug resistance; evolution; genetic diversity; genomics; Mycobacterium; phylogeny; positive selection; tuberculosis

Indexed keywords

ANTIBIOTIC AGENT; ANTIGEN; ETHAMBUTOL; ISONIAZID; LACTATE DEHYDROGENASE; MCE1 ASSOCIATED TRANSMEMBRANE PROTEIN; MEMBRANE PROTEIN; RIFAMPICIN; UNCLASSIFIED DRUG;

AMBB GENE; AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL STRAIN; CODON; DIVERSIFYING SELECTION; DRUG RESISTANCE; DRUG RESPONSE; GENE MUTATION; GENETIC ANALYSIS; GENETIC VARIABILITY; KATG GENE; MOLECULAR BIOLOGY; MOLECULAR EVOLUTION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN FUNCTION; RPOB GENE; RV0176 GENE; RV1872C GENE;

COMPUTATIONAL MOLECULAR BIOLOGY; DIVERSIFYING SELECTION; DRUG RESISTANCE; EVOLUTION; GENETIC DIVERSITY; GENOMICS; MYCOBACTERIUM; PHYLOGENY; POSITIVE SELECTION; TUBERCULOSIS;

AMINO ACID SEQUENCE; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; EVOLUTION, MOLECULAR; GENES, BACTERIAL; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; PHYLOGENY; POLYMORPHISM, SINGLE NUCLEOTIDE; SELECTION, GENETIC; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN;

EID: 84877727980     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/mst038     Document Type: Article

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