An abnormal apelin/vasopressin balance may contribute to water retention in patients with the syndrome of inappropriate antidiuretic hormone (SIADH) and heart failure

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 5, 2013, Pages 2084-2089

  Blanchard, Anne ^a,c,f   Steichen, Olivier ^a,c   De Mota, Nadia ^g,h   Curis, Emmanuel ^b,c   Gauci, Cedric ^d   Frank, Michael ^a,c,f   Wuerzner, Grégoire ^a,c,f   Kamenicky, Peter ^i,j   Passeron, Amélie ^e   Azizi, Michel ^a,c,f   Llorens Cortes, Catherine ^g,h  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b Laboratoire de Biomathématiques   (France)

^c HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^d Départements de physiologie   (France)

^e Service de Médecine D   (France)

^f INSERM   (France)

^g PSL RESEARCH UNIVERSITY   (France)

^h SORBONNE UNIVERSITÉ   (France)

ⁱ UNIVERSITÉ PARIS SACLAY   (France)

^j BICÊTRE HOSPITAL   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

APELIN; COPEPTIN; SODIUM CHLORIDE; VASOPRESSIN;

ADULT; AGED; APELIN BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; COPEPTIN BLOOD LEVEL; CROSS-SECTIONAL STUDY; DISEASE MARKER; FEMALE; HEART FAILURE; HORMONE ACTION; HORMONE BLOOD LEVEL; HUMAN; HYPONATREMIA; INAPPROPRIATE VASOPRESSIN SECRETION; MALE; OSMOSIS; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RELIABILITY; TEACHING HOSPITAL; VASOPRESSIN RELEASE; WATER LOADING; WATER RETENTION;

ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; FEMALE; GLYCOPEPTIDES; HEART FAILURE; HUMANS; HYPONATREMIA; INAPPROPRIATE ADH SYNDROME; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; NEUROPHYSINS; PITUITARY GLAND, POSTERIOR; PROTEIN PRECURSORS; SALINE SOLUTION, HYPERTONIC; UP-REGULATION; VASOPRESSINS; YOUNG ADULT;

EID: 84877712064     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-3794     Document Type: Article

References (18)

1. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251:471-476.
2. Habata Y, Fujii R, Hosoya M, et al. Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum. Biochim Biophys Acta. 1999;1452:25-35.
3. De Mota N, Reaux-Le Goazigo A, El Messari S, et al. Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. Proc Natl Acad Sci USA. 2004;101:10464-10469.
4. Reaux A, De Mota N, Skultetyova I, et al. Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain. J Neurochem. 2001;77:1085-1096.
5. O'Carroll AM, Don AL, Lolait SJ. APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids. J Neuroendocrinol. 2003;15:1095-1101.
6. Reaux-Le Goazigo A, Morinville A, Burlet A, Llorens-Cortes C, Beaudet A. Dehydration-induced cross-regulation of apelin and vasopressin immunoreactivity levels in magnocellular hypothalamic neurons. Endocrinology. 2004;145:4392-4400.
7. Azizi M, Iturrioz X, Blanchard A, et al. Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli. J Am Soc Nephrol. 2008;19:1015-1024.
8. Cernaro V, Lacquaniti A, Lorenzano G, et al. Apelin, plasmatic osmolality and hypotension in dialyzed patients. Blood Purif. 2012; 33:317-323.
9. Llorens-Cortes C, Moos F. Opposite potentiality of hypothalamic coexpressed neuropeptides, apelin and vasopressin in maintaining body-fluid homeostasis. Prog Brain Res. 2008;170:559-570.
10. Morgenthaler NG, Struck J, Alonso C, Bergmann A. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem. 2006;52:112-119.
11. Szinnai G, Morgenthaler NG, Berneis K, et al. Changes in plasma copeptin, the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects. J Clin Endocrinol Metab. 2007;92:3973-3978.
12. Ellison DH, Berl T. Clinical practice. The syndrome of inappropriate antidiuresis. N Engl J Med. 2007;356:2064-2072.
13. Földes G, Horkay F, Szokodi I, et al. Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure. Biochem Biophys Res Commun. 2003;308:480- 485.
14. Miettinen KH, Magga J, Vuolteenaho O, et al. Utility of plasma apelin and other indices of cardiac dysfunction in the clinical assessment of patients with dilated cardiomyopathy. Regul Pept. 2007;140:178-184.
15. Fenske W, Störk S, Blechschmidt A, Maier SG, Morgenthaler NG, Allolio B. Copeptin in the differential diagnosis of hyponatremia. J Clin Endocrinol Metab. 2009;94:123-129.
16. Nickel CH, Bingisser R, Morgenthaler NG. The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department. BMC Medicine. 2012;10:7.
17. Chen MM, Ashley EA, Deng DX, et al. Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation. 2003;108:1432-1439.
18. Chandrasekaran B, Kalra PR, Donovan J, Hooper J, Clague JR, McDonagh TA. Myocardial apelin production is reduced in humans with left ventricular systolic dysfunction. J Card Fail. 2010;16:556-561.