The LIF receptor antagonist PEGLA is effectively delivered to the uterine endometrium and blocks LIF activity in cynomolgus monkeys

Contraception

Volumn 87, Issue 6, 2013, Pages 813-823

  Aschenbach, Lindsey C ^a   Hester, Kim E ^a   McCann, Nicole C ^a   Zhang, Jian Guo ^b   Dimitriadis, Evdokia ^c,d   Duffy, Diane M ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d MONASH UNIVERSITY   (Australia)

Author keywords

Cynomolgus monkey; Endometrium; Leukemia inhibitory factor receptor; Uterus

Indexed keywords

COCHLIN; CYCLOOXYGENASE 2; CYTOKINE RECEPTOR ANTAGONIST; POLYETHYLENE GLYCOL LEUKEMIA INHIBITORY FACTOR RECEPTOR ANTAGONIST; SOMATOMEDIN BINDING PROTEIN 3; STAT3 PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ARTICLE; DRUG BLOOD LEVEL; ENDOMETRIUM; ENDOMETRIUM CELL; EPITHELIUM CELL; EXPLANT; FEMALE; HAPLORHINI; IN VITRO STUDY; IN VIVO STUDY; LIMIT OF DETECTION; NONHUMAN; PROTEIN PHOSPHORYLATION; SAMPLING;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; CONTRACEPTIVE AGENTS, FEMALE; ENDOMETRIUM; FEMALE; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAMUSCULAR; INJECTIONS, SUBCUTANEOUS; LEUKEMIA INHIBITORY FACTOR; MACACA FASCICULARIS; METABOLIC CLEARANCE RATE; OSMOLAR CONCENTRATION; PHOSPHORYLATION; POLYETHYLENE GLYCOLS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TISSUE CULTURE TECHNIQUES; TISSUE DISTRIBUTION;

EID: 84877700004     PISSN: 00107824     EISSN: 18790518     Source Type: Journal    
DOI: 10.1016/j.contraception.2012.09.032     Document Type: Article

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